Immune/natural killer cell treatment when TTC or pregnant (aka the 14th pred thread)

Dildoos - good to hear things holding steady. Def wouldn t want to be doing the SIL thing but nice ur sister is suppportive even if a bit enthusiatic with it !

Thanks ladies. So my total nk absolute count was 250 (should be less than 200), total percentage 15.8% (should be less than 12) activity was borderline 0.87 (should be less than 0.8, and borderline tnf alpha 31.6 (should be less than 31).

Dr S advised the complex programme. Its difficult to know whats best partic when there s controversy around blood nks. I suppose because i ve actually only had one miscarriage i kinda wonder if maybe next time it might just be ok as i am so nervous of taking anything in pregnancy. But since my main issue is actually getting preg (2yrs ttc DS and coming up 18 mns ttc no 2, 9mns from mc) maybe my immune system is so bad i can t even get preg at all....

I wondered about doing the one off uterine biopsy with prof quenby as that might help confirm things.

And i think some docs that do pred at bfp do intralipids 3mnthly when trying, maybe i ll ask dr s about that.

Trying hope you have a good acu session. What day in cycle will you be?
How are you determind? Sunny?
My sil text today doesn't know anything as I really don't need that in put!! So instead her 2 month old baby wants to know when his auntie can come to a local park with him and his sister ( basically so I do the running around whilst mummy puts her feet up and watches! ) been there done it I am busy washing my hair for the next week as cannot face it!

My darling sister however guessed there was an issue today an from knowing ran round like I was dying so one extreme to the other bless her heart I ha to point out that I just needed normality xx

great to hear its still only brown. when is ur next blood test?

Evening all.

Staying positive not over until the fat lady sings and all! As I plan no singing yet the game is not over!

Still no pregnancy symptoms but equally touch wood no red bleeding either so staying hopeful.

it depends. usually they finish once they have recruited enough people then close it. but they will obv have to wait till enough of the people have had pregnancies and then success/miscarriage. if u look it up it should say somewhere when the results be published? i think the miscarraige association prob has info on it.

dildoos hope ur keeping positive.

sunny hope ur feeling better after ur wobbly.

Yes that's me 'eurothyroid' I am aware of it and Dr S mentioned it too but of course not being finished there is no evidence to know what to do. Do these trials have an end date or so they wait for a certain no of participants?

think mine was 1.2 then. makes sense is hrs was borderline at 0.97

its the absolute count which MR S said was imp i think. mine was normal i rem! but don't rem figure and don't have it to hand

determined i meant to say. have u looked up the TABLET trial. i don't know if outcome is out yet, but it was looking at giving thyroxine to people with high antibodies EVEN if you thyroid function is normal (which i think is ur situation). have a look into it and maybe discuss with Mr S?

maybe the hydroxy will mop them up though!

Oh sunny you are being so tough! Its just pants. I hope you can have a nice eve with DH tonight?

Dildoos how you holding up? I hope ok and I am so positive for you!

Good for you on the positivity Trying! I really do believe PMA is a powerful thing - I need more practice though I think :)

Glad your cycles are panning out better Hula. Its really hard to know what to do. I don't really know what my count was - is it the total NK cell absolute or the total NK percentage? My activation was 0.97 so borderline. I think maybe my big problem is Thyroid antibodies perhaps as these were 6 times over the top limit/range :( but as Trying said Free had very high NKs and has 2 pred babys :)

xxx

hi hula

my counts were normal but my activity was just into the "high range". ic ant rem exact no maybe 1.2?? but it wasn't borderline, and wasn't very high and i rem thinking "oh i just go into the high category"

freelance who has had 2 pred babies at age over 37 had the highest levels Mr S has ever seen! and she's now got 2 babies!

I've seen so many stories of women taking it only from BFP and it working. and also some who miscarry and didn't take it from ovulation. its all very confusing!! i would try take it from BFP and if u can't tolerate it u can talk to MR S about other options, like switching to hydroxy or more intralipids etc? but fingers crossed u will be fine!

Sunny - It s is a nightmare sometimes when things like that just derail u unexpectedly.

Afm i m also just starting tww (1 dpo), how may dpo are u Trying ? we ll prob be testing a similar time.

Things seem to have recovered from the dire 2 week cycle i had after first try of pred. I ve chickened out of trying pred this month as think i should just let my body get back to normal. In fact i ve started to worry about whether i ll tolerate it when preg.....but if i finally got preg and didn t take it and then mc i d be beside myself, it s so hard. Those who had high nk cells, what were ur total counts and activity ? (if u don t mind me asking)

i been having acu for 6 months now. i just stopped for a month over xmas etc as way away at parents. but I'm restarting next week!

Thanks trying will do that now.

Bless you 2 ww fx for you! Well done with keep telling the negative thoughts to piss off that's exactly where these negative thoughts need to go.
Did you think any more about the acu?

Yes bloody john Lewis xx

Dildoos pm sue she said she had a bag left Over and would send them. She might not get them to in time though but might??? Just send her a private message. Ow ring u gp at 755 on Monday and ask for a telephone Appt and get the script. They will have a letter from shehata on their system so Can do it.

John Lewis is the worst! All the babies gravitate there. It's so hard sunny. U sound like ur doing well in general.

Ive started deep Breathing and postive thoughts only. I keep telling my Negative ones to piss off and leave me alone! I must sound mad!
I literally tell them to piss off in my mind!

Not much to report dildoos, in another 2ww wait! Lets see!

Think postive think postive. When ur next blood test? I have everything crossed for u x

Oh sunny I imagine that was just awful bless you. Wobbles are totally understandable and should be treated with care! Do you manage to make a quick exit and some retail therapy? What about some quality time with your dh tonight? Good movie? Choc? Wine?
Glad the bleeding hasn't gone on for too long! I always get confused when I start testing for ovulation again, are you aware p when you should start? Have you thought anything about your plan for this month? Trying anything new? Take care xx

Hula thankyou. All of you thank you!
I am running low on cyclogest will see me right until Monday dr a was away Friday so no chance of prescription postage. Any suggestions?
We are due snow tonight so am excited for that

Ah dildoos i can inderstand that but i d say that the scan is as expected for 11 dpo, hcg level seems on right on track and bleeding is brown so you re definitely in with a chance. Stay positive and we will WILL those numbers to double by monday !

Bless you all. I am just confused xx

That is a really good hcg level at this stage. I would expect it to be lower if you had miscarried. The main thing will be finding out whether it doubles or not. When are you going back for the next blood test? Sending lots of positive thoughts your way, xxx

Hi dildoos. So glad u got to go to epau. Are u feeling better or more confused?! I don't think thy can see much at 11dpo. My first miscarriage my hcg was like 50. I think 222 would be quite good at this point. Plus if they can still see the corpus luteum u prob did just ovulate recently.
Keep being positive. Visualise it all going well, lots of hugs

Hi Dildoos, pleased you got some answers/info at least today! I would think that's good?! Don't most preg tests pick up hcg at 12/25 for cb? Are you 11dpo today? And it doubles every 48 hours or so? Am pants at maths but would think that sounds good? Did the epu give u much reassurance? Advice?

Xx

Thanks hula hcg at 222 so I don't know what to make progesterone level very good but said as on cyclogest this is expected xx