Immune/natural killer cell treatment when TTC or pregnant (aka the 14th pred thread)

Thanks lovelies! Will let you know how I get on afterwards. Hope you are all feeling Christmassy! I'm feeling really ropey again so hope that is a good sign. Xxx

Thanks trying...makes a bit more sense now! (Of a nonsensical situation ha ha!). I hope you and DH have some nice things planed over the xmas period!
Best of luck for tomorrow hope ;)

Xxx

Hope hope ur feeling positive about ur scan on Monday! I have everything crossed for u. Looking fwd to hearing ur good news

With the karotype if there was something The only option is ivf with pre genetic dertermination (PGD). The rates of doing that aren't great so I can understand why they didn't test for it. In USA though they do a lot of PGD for this reason....I had mine and DH karotype done and mr s told Me he doesn't test for it as no point! (Nhs tested it)
The hidden infections and all that dq mismatch I suppose is like nk cells
In that not much reserch but seems
To work for some! I've decided to give mr s a go and if I have another 2 miscarriages (please I hope not!) look at those routes too. We will get there in the end! I'm feeling hopefull that this is my Month! Except not sure if the Xmas drinking will help my DH sperm! Oh well. Got to enjoy Xmas!

My SIL keeps saying how sorry she is for us. I don't like pity. It's driving me up the wall. Deep breathing!

Hope everyone has done their Xmas shopping!

Hi snoopy not hijacking at all...this what this thread is about!! I have very high thyroid antibodies and have spent the year trying to get my head round it all. I'm not on levothyroxine or anything like that yet as much thyroid is functioning ok...just....! but I did challenge this when I was last preg. Anyway, have you had all the immune and hormone tests you can have? (Sorry if repeating).

Thanks trying...I know this deep down but i do wonder why elsewhere they do karyotype, infections, dq alpha etc if there is no point in it?? It's more a case of won't then can't I feel! very frustrated to be told I will probably just end up having a baby in the end with or without treatment is very frustrating!!

Hi snoopy! Not hijacking at all! Hope ur ok? Thyroid problems can be caused by many things and only in some is it due to autoimmune causes. Apart from addisons (can be autoimmune and sometimes isnt) the other conditions you mentioned are usually autoimmune either...maybe someone with thyroid issues can add More? Like free?

Determined-I know it's annoying when they can't do anything more. That's wot made me go see me s. but you have had the full work up and hopefully it's just a matter of time like the rest of us.

X

Sorry that should say Addison's disease not addions.

Hello everyone. Sorry to hijack your thread again but you seem to be the most knowledgable bunch on the Internet!

Some of you may remember I had a MMC a couple of weeks ago. I was diagnosed with hypothyroidism about 18 months ago but suspect I have had it a lot longer and I am on levothyroxine.

I spoke to my gp and told her how scared I was about miscarry img again so they did a blood test for thyroid antibodies for me. I had a call yesterday from a doctor who said the level was '6' so they wouldn't consider it an autoimmune problem.

My question is if it isn't autoimmune then what has caused my thyroid to not function properly? I have no relatives with the condition (and they have been tested! History of psoriatic arthritis, sarcoids, addions and leukaemia in immediate family), I have never had radiation therapy, never taken any thyroid inhibiting medications and haven't been diagnosed with any other condition.

Just feel a bit lost and don't really understand why my body isn't working.

Sorry this is so long and a bit off topic.

Ahh thanks Tumtimes that's so lovely to hear and stories like that keep us going! Wishing you a fantastic 1st Christmas with your little girl

Sorry not been in here much but been so manic this week with work and travelling. :(

So I had my NHS appointment today (brought forward). They were really good in chatting through everything however there arent any further tests I can have. (karyotype no solution so they don't test, infections no evidence so again don't test etc etc, NK cells not enough evidence...you get the drift). Basically have had more tests already than would get on NHS (apart from infection and kt) and I should just keep trying and I will get success as most ladies do in the end. Not sure how I feel about that...part of me feels rubbish, why can't we rule these things out...the other is positive...will get there in the end!!! Urggh, not sure how I feel right now...bit pants I guess!!

Hope everyone is feeling ok today ready for xmas? Xxx

Tumtimes thank u for coming on here with ur story. Like u said, it keeps us lot going. It's hard not to set "deadlines". I think the constant ttc is so tiring for us all...
Enjoy ur daughter :). This Xmas u do have her! Yay :)

Heya all just been catching up with this thread as haven't been on here for a while.

I just wanted to echo the not giving up hope sentiment. It really struck me a couple of comments on here about having internal timelines. I too said to myself stuff like next Xmas I would be with child and then that next Christmas still no baby it. In fact a year after my first miscarriage I was having another one the following year. However,like many have already said on here treatment has worked for so many people with similar issues and lots of times when I thought all was lost someone would pop in here from a previous pred thread to tell us their success stories. And I clung onto that.

And now I Am thankful to say that I am a 'success' story, my daughter (can't believe i am saying that word, daughter) is 15 weeks old and the light of mine and my husbands lives. It happened for us after three miscarriages. I was on pred, cyclogest, clexane and aspirin and we got there in the end. And you will too. Xx

Good plan sunny. U sound much calmer and cooler than my crazy post before!

Morning girls!

Well af arrived as expected. I'm now freakin out that I can't get preg because of these stupid NK cells. Sunny when u see shehata it may be worth discussing too? I don't rem ur levels but they were high I presume? My brain has gone into overdrive and I've started thinking about ivf and also failed ivf coz of these nk cells. Mine were only just high but I know they fluctuate and can be lower post period....which is when my bloods wefe taken. oh dear what to do. Might take the pred next month and hope that calms them down? No idea what to do...I don't know if I'm being crazy or actually reasonable? I'm really worried about not becoming preg and ontop of that miscarriage after miscarriage. Don't think I can handle another ten years of this crap!!!

Thanks dildoos! Have a great time. I'm off on holiday in a few days. Am running away from Xmas and reality!

Hope ur feeling better sunny
Hope not long till ur scan
And rosa hope ur time off starts soon
X

Morning ladies, how are you all today? The big day a week today
I am off away until Monday first for my sisters 40th then for my mums 60th. So if I don't get to visit here , take care, chins up, 2015 will be this threads year! So use Christmas to eat, have drunken sex and get those BFP's (well that's what they do on Jeremy Kyle) x

I find it reassuring that all of us have similar feelings and emotions and we end up there in the end! And yes it's so lonely, noone really gets it.
Off to acu soon! (It's not helped me get preg so I'm not sure why I'm still doing it!)

I've done that before. I cried a lot on new yr at like 1am and I thought next year I'll be preg or baby. And it hasn't happened :(. It's shit! I rem
Saying to my Husband lets hope 2014 is the year.

I have no idea re the year thing. My dad keeps telling me I have to wait a year before I discuss options but hasn't said what happens then really! The fact u have been preg twice shows u can get preg. So lets just hope it will happen in the next few months. Did u have ercp or natural miscarriages? Any issues medically with them? Infections etc?

Glad u feeling a bit better.

Oh god! Long post! Sorry about that!

Hi sunny. I'm so sorry :(. Ur usually so postive and sunny! Ur allowed to feel like shit sometimes. ESP when bloody af coming. It's so so so hard. I cried yest for an hr the whole way to work. Turned up looking like a right wally. The fear of it never happening is so scary it fills us all im sure with dread. But it will happen. These days everything is available medically to make it happen. My acupuncture lady always says if ur strong in ur mind and keep on going and going someway or another it happens. Weather is ivf/iui/surrogacy/donor eggs donor sperm or a list of other things. It does happen. She said when she first started she felt nervous saying that but now she's confident telling women it will happen. She said some women decide to stop and make peace with that but the others suceed.
It seems so unfair and cruel though. That our journey is so long and sad. But keep having hope and believe it will happen.
I think getting DH sperm checked is def a good way fwd. u know u are ovulating....and u have got preg before so it will completly happen again. How long were u trying for before u did SO. U still have 2
More goes. Also did u know even if perfectly timed u only have a 20 percent chance of succeeding. Bad egg, bad sperm. Sperm not reaching egg etc.

It's really sad. I feel sad when I loose hope. So try keep having
Hope. Believe it will happen. And keep positive that it will happen in the next few months. I really really
Hope it does for u.

Saying all this I'm terrified I now can't get preg too?! I have a timeline in my head now of when to do SO and when to go for ivf. I'm just praying it doesn't come to that. But if it does-I'll still have my baby it's just going to be some
More tears and stress! When ur baby comes u will be so grateful and appreciative and a lovely mummy!

Rosa u deserve a well earned break. U sound like u have been working hard and giving urself a hard time. I
Hope u have time off and can recharge and start the new year
Postive. I think doing SO is def a good idea I know they tend to move quicker for women over 35. When were u last preg? How long does it usually take u? I read on one of those forums of a woman in ur situation with problems with inflimiab etc. she's now had a baby and I think she was older than u. I hope u also get ur bfp soon :).

Hope - hope ur not poking ur boobs too much and containing the anxiety. I rem crying a lot in my third preg as I just knew it wasn't going to work. The anxiety is so hard to deal with. It's something I know I will struggle with next time.

Hi to the others too! And think a lot of us need a hug

2015 HAS to be better

Sunny sorry to hear your down today. Hugs to you . X

Hi all

Hope- fantastic news... So v happy for you. You, like your name on this, give me most hope given your similarities. Great to hear all going well.. Except moonface of course but assume that goes away when you stop pred and small price to pay. Thanks so much for thinking of me and all your v kind words. I don't know why I was hitting such a low point but needed a kick & a hug. Do have friends but not been leaning on them much at all as I guess I'm trying not to be the friend to avoid. My lovely DH is bearing it all so well.

Free - I would be v grateful for hydroxy if still going? Did you ever have side effects over time from it? How are you now.. Getting so close!!:)

Trying - sorry you're out again- know the feeling but it's a numbers game and will happen. I'm going to check FSH levels etc in Jan then consider super ov in Feb. Views if worth it welcome.

Hi everyone else. Hope Christmas shopping in a better place than mine... Not started yet! Too late for online? X