What do we REALLY think about the weight loss jabs?

Why are people so aggressive about people having a discussion about health?

The aggression always appears on these threads. I find it baffling.

Sneering, mockery, weird accusations.

Thank you, that’s very helpful context and makes sense.

I think this all just highlights how crucial it is for data to be collated. The total number of UK prescriptions versus all the hospital data from severe side effects alongside the patient data for those affected so that with so many people now taking it the large scale data is captured so it’ll be much clearer where the risks lie and the relative risks based on dose, weight/ BMI/ duration of taking the drug, etc.

No I’m not saying you’re morally degenerate? You can do whatever you want to do, as can every other adult commenting on this thread. It sounds like you’re very happy with what you’re doing, in which case just crack on with it!

So have I. But I constantly think about food. I am never full. I never leave a thing on my plate. Are you similar? It’s just so hard to constantly have to eat consciously when you’re hungry and you dont get the “I’m full” signal. I am tired of that noise controlling me or trying to. I wish I could just quieten that, then I know I would be fine and “normal” ie one of those people who says “I’ve had enough, I’m full now” and it be real.

Having been knocked out by COVID twice- 3 weeks in bed both times- I wish someone would give me a vaccine I really do. You can't even pay for one very easily.

You sound like you don't trust medical science so maybe it's best in your case to carry on being fat.

Really? Why are people so aggressive about people having a discussion about health?

Many of us who are completely unbothered by or uninterested in our own weights or those of other people and pay no attention to this have friends or family who are taking/ are considering taking these drugs so we are concerned about the risks.

People also rightly may have concerns about the costs to taxpayers of treating side effects especially in cases where there have been private prescriptions without proper medical oversight and outside the NHS criteria, so no detailed cost/ benefit analysis has been done of the savings to the NHS of moderately overweight people using the drugs versus the cost of treating those who develop side effects which sometimes can be very severe. It’s obviously pertinent that there’s emerging evidence that these are more prevalent in cases where they are used only for weight loss not just to treat diabetes, if the findings of the study quoted by the PP are accurate.

It’s also of general public concern that pharmacies are able to prescribe medication based on self-reported forms which may be inaccurate/ misrepresent/ omit information because that is a safety issue that could affect prescribing of many other drugs as well. Perhaps there should be a better system where patients need to download an actual copy of their medical records from the NHS app to submit with online prescription requests, as a safeguard.

There are clearly various reasons why people who do not need or want these drugs have a legitimate interest in this discussion. It’s quite a leap to assert we are all “jealous” of obese/ severely overweight people who are feeling so desperate and worried about their weight that they feel taking drugs is the only way they can successfully address this. Why would anybody be jealous of someone in that situation?!

Yeah well I have been honest enough to say yes I can be insanely jealous of the wonder switch of these drugs that I am unable to afford or have prescribed 🤷‍♀️

A pound a week - which is my experience (other than the very beginning) is hardly can hardly be considered a crash diet, can it? If I lost a pound a week by eating less and going to the gym, you'd be all over me. But I lose a pound a week with an injection, eating less and going to the gym I'm 'cheating' and somehow morally degenerate?! How does that work then?

What’s really sad is that they aren’t available to everyone who might benefit.

A biologically plausible explanation for many reported cases is gallstone-mediated pancreatitis secondary to rapid weight loss, rather than a drug-specific inflammatory mechanism. Rapid weight loss of any cause, including very low calorie diets and bariatric surgery, is a recognised risk factor for gallstone formation through bile supersaturation, impaired gallbladder emptying, and bile stasis. Gallstones remain the most common cause of acute pancreatitis in clinical practice.¹ ²
Randomised trial evidence shows GLP-1 receptor agonists are associated with an increased risk of gallbladder and biliary disease, particularly at higher doses, longer duration, and when used for weight loss.³ This association provides a coherent mechanistic pathway linking treatment-related weight loss to gallstone formation and subsequent pancreatitis, without invoking a direct pancreatic effect.
The apparent rise in pancreatitis reports should also be interpreted in the context of unprecedented exposure and heightened awareness. With more than 25 million packs dispensed in the UK and an estimated 1.6 million users, rare adverse events will inevitably become more visible. Spontaneous reporting systems are essential for signal detection but cannot establish incidence or causality.

this is interesting of course given the monumental uptake of the jabs you will hear more stories.

but people are failing to acknowledge that you are already at an increased risk anyway if you are fat.

Sorry for the tone of my message but what you wrote just really got to me.

“There still has to be a calorie deficit - OK easier to achieve with Mounjaro, but you can’t just eat what you like and expect the weight to just fall off. The time on WLI’s is best used to change eating habits and learn what works best for you.”

Saying to someone that it’s not a case that you can eat what you like and the weight will fall off is absolutely treating thst person as ignorant at the least.

It really touched a nerve. I AM maintaining my weight loss but I have accepted that I cannot lose more AND maintain it. I’ve worked out my TDEE and monitor what I eat and weigh regularly so I have educated myself on what my body does. There is nothing wrong with what I eat. Actually ironically if I bought and ate crap I might be able to afford WLI. I prioritise good food. It would absolutely be possible for me to lose those final two stones if I could quieten the food noise and feel satiated at a lower calorie level.

I’m pleased things are going well for your husband.

I lost loads of weight on Mounjaro, developed gall stones, & had my gallbladder removed in an operation that was much easier because of the weight loss. There is a tiny possibility some kind of serious long term effects we don't know about yet will happen because of GLP 1s, but I was happy to risk it. I was never able to lose weight naturally & keep it off because I have a ridiculously large appetite, which I may have been born with, as my parents remember me being obsessed with food even as a tiny child.

Got the pancreatitis?

it is just pancreatitis there’s no the.

You sound like a right dick tbh.

Why do you think people are angry about it? 🧐

Wow, that is concerning given it’s been presented as a “rare” side effect. That’s not a small increase in risk at all especially for something so serious.

No, they showed there is a slightly increased risk, but that the overall risk is low.

From January this year

A new safety warning to doctors and patients around a rare but potentially fatal side effect of glucagon-like peptide-1 (GLP-1) receptor agonists has been issued by UK regulators.

Sold under brands like Ozempic, Wegovy, and Mounjaro, GLP-1 injections are for weight loss and to treat type 2 diabetes.

But their use has been linked to a rare risk of developing pancreatitis, a dangerous inflammation of the pancreas that can prove fatal in extreme cases.

GLP-1 drugs: New warning after rise in reported deaths from pancreatitis | The BMJ

Could have fooled me 😂

Gosh people get so so angry these drugs are available, effective and safe, it’s really sad,

I don’t think it is particularly difficult to prepare meals at 1350 calories per day if someone plans meals sensibly and eats regular portion sizes. It’s certainly perfectly possible because that’s precisely what people do as a result of taking these drugs or when they diet naturally! Normal calorie intake for a woman should be 1600-2000 calories and only at the higher end of that if you are quite tall/ young/ very active (which most obese people are not). For weight loss 1200 to 1500 is quite normal so I don’t think 1350 is extreme? It just means making slightly healthier choices for most meals.

If someone has diabetes or pre-diabetes or insulin resistance etc causing metabolic issues then of course the balance of risks and benefits will be different (although often things like insulin resistance are of course caused in the first place by poor diet/ over eating/ lack of exercise).

My comment was not about people who have other separate health conditions which the drug has been shown to improve, but people who are taking these drugs purely for weight loss.

studies now show there is no increase in pancreatitis due to weight loss meds, and in fact the opposite it protects your pancreas and reduces the cases of pancreatic cancer too.

im sorry she died, but the pancreatitis wasn’t due to the meds, factually not one person has died globally due to correct usage of the legitimate medication. I’d ask for more info,

What part of my answer called you stupid?

What on earth in my post made you feel as if I was telling YOU, as a complete stranger who I have zero knowledge of, what to do?

OP asked what we think, and I answered for myself opening with the words, 'I PERSONALLY' Also, your post is simply incorrect. It is entirely possible to gain muscle while losing weight. I work with colleagues with PhDs in osteology and muscular health, so I do have awareness on the effects of not eating enough protein with weight loss medications. Unfortunately due to the appetite suppression side effects, it is very common.

I’m glad you’ve weighed up the risks and benefits for yourself and found something that works for you. Good for you. But as stated, I PERSONALLY (defined as: I, myself) would not use them. My priority is avoiding sarcopenia down the line; I worry about my future falls risk and losing my independence as I age.

You make your choices, I’ll make mine. Stop projecting.

I was responding after a slew of posters declared that it was nothing to do with the WLI themselves, that it was just a side-effect of rapid weightloss.

It is clearly not just that, according to the meta-analysis.

🤔

Well you need to educate yourself then!

”Shooting up drugs” 😀😀😀

And other people will think you’ve been using them if you lose weight? Are you really that sensitive you’d be bothered by that?

Honestly. Lol I have lost on calorie counting. Does not cost a penny.