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Share your dilemmas and get honest opinions from other Mumsnetters.

To ask if anyone has taken Naproxen?

65 replies

thewaylifegoes · 09/03/2026 07:25

I’m posting here for traffic, and I’ll admit right now I’ve got some health anxiety.

I have just returned from a ski trip where I have unfortunately torn some ligaments in my ankle. I’m on a waiting list to be assessed to see if I need surgery, or whether it can heal naturally. In the meantime, my GP had prescribed naproxen and omeprazole for me.

But I am totally confused. The packet of the naproxen says to take two a day. The omeprazole says one tablet a day, but during our consultation the GP said to take an omeprazole with each naproxen I take. I’m also aware that omeprazole can have some bad long term side effects, so I just feel a little confused.

I’ve held off taking them for a good few days now because of this but I’m in so much pain that I need to take one. My question being - how?!

OP posts:
Isobel201 · 09/03/2026 09:47

I take naproxen, and tbh haven't had any problems with it. Do start it because you can't carry on with pain. It won't do anything to your stomach lining as long as you take it with food. I take the omprezol once a day in the evenings, but that's just my personal prefence as I have a lot of other tablets to take in the mornings.

randomchap · 09/03/2026 09:44

Reepycreepy · 09/03/2026 09:40

I’ve taken Naproxen. It caused me to bleed from my bottom. Not good.

I've never had that, but it did take all my pain away and enabled me to get back to work

Op has health anxiety, it's not helpful to point out that you got a very rare side effect

SpainToday · 09/03/2026 09:41

Like many posters, I was always told you take omeprazole to protect your stomach from the effects of naproxen.

Reepycreepy · 09/03/2026 09:40

I’ve taken Naproxen. It caused me to bleed from my bottom. Not good.

PistachioTiramisu · 09/03/2026 09:39

Naproxen is a very effective NSAID in my experience (I take it for gout) - it starts to work within an hour and takes the pain out of the joint fairly quickly. I only take it for the shortest period possible as it does make me feel nauseous but rather that than the pain!

I take an Omeprazole in the morning and then one Naproxen after breakfast and another after dinner.

You can buy Aleve (basically Naproxen) over the counter in the US - my friend brings me a bottle when she visits. Don't know why we need a prescription here!

Lokielo · 09/03/2026 09:38

Omeprazole side effects that I think you might be worried about such as increased risk of bone fractures are only a concern for long term use. Short term, most people don’t really notice they are taking Omeprazole.

bigboykitty · 09/03/2026 09:36

thewaylifegoes · 09/03/2026 07:59

I’m holding off a) because of the concerns I had about the omeprazole and b) because I’ve only been given 28 naproxen tablets and I don’t want to use them all up

Just take what you've been prescribed, which is absolutely standard prescribing. Very silly to think that your health anxiety is a better basis for deciding what medication to take, rather than listening to the GP or the pharmacy.

Tinatubby73 · 09/03/2026 09:32

Naproxen can. Damage the lining on your stomach so omeprazole prevents it! I know as I was on naproxen and ended up having a magic eye as I was having stomach problems, and they told me this was the cause. (I wasn't taking the omeprazole)

RockyKeen · 09/03/2026 08:17

I’ve taken it for my back and for periods it’s just another anti inflammatory.
its not unusual to give omeprazole for otc painkillers if you will be taking more regularly than usual because of an injury as a opposed to a couple of days of the flu.

Pepperedpickles · 09/03/2026 08:14

PoachedSmoke · 09/03/2026 08:09

This is an incredibly common prescription OP.

You take 1 Omeprazole in the morning with water only.

30 mins later take 1 Naproxen with food.

Take the other Naproxen tablet in the evening, at least 8 hours after the first.

Do not skip doses or save tablets - it has a cumulative effect.

Check with your pharmacist if worried, but both drugs are very safe for short term use.

This.

I have long complex term health issues and many people like me with the same issues take ppis like omeprazole life long / long term - I’ve been on high dose esomeprazole for 10 years now. Yes there is a lot of stuff in the media at the moment about the dangers of ppis causing absorption issues etc but the vast majority of people take them with no issue whatsoever- and you’re only going to be taking it for a very short time.

Naproxen is essentially a stronger ibuprofen. Just go for it. Better than being in pain!

PoachedSmoke · 09/03/2026 08:09

This is an incredibly common prescription OP.

You take 1 Omeprazole in the morning with water only.

30 mins later take 1 Naproxen with food.

Take the other Naproxen tablet in the evening, at least 8 hours after the first.

Do not skip doses or save tablets - it has a cumulative effect.

Check with your pharmacist if worried, but both drugs are very safe for short term use.

Octavia64 · 09/03/2026 08:09

I have taken naproxen in and off for a long time.

recently my gp insisted I take omeprazole with it and like yours he was totally unclear about what he meant.

i didn’t take naproxen routinely only as and when and so as the instructions were take omeprazole with naproxen I took an omeprazole every time I took a naproxen.

i can now inform you after my gp called me an idiot that this is not what he meant,

I’d suggest contacting them to clarify.

MrsHaroldWilson · 09/03/2026 08:07

I used to take it for menstrual pain (eventually diagnosed as endometriosis). It's just a very strong NSAID like Ibuprofen or aspirin. As pp have said, the main risk with the naproxen is damage to the stomach, so you shouldn't take it on an empty stomach. The omeprazole is a proton-pump-inhibitor which reduces stomach acid production, so this will protect your stomach against damage from the NSAID. My understanding is that you should follow the dosage instructions from your GP over what's printed on the packet.

Whyherewego · 09/03/2026 08:04

The effect of the naproxen is anti inflammatory. By not taking it you are basically missing out on the benefits it will given when youre healing from the injury. It's a cumulative effect so taking it once and then stopping or whatever also is pointless. As PP have said the stomach lining is what youre getting with the omazeprole and if you take one at least you will get the benefits. So I'd personally be starting on the meds !

oviraptor21 · 09/03/2026 08:04

When I was prescribed naproxen it was standalone - no omeprazole with it.
Unfortunately the naproxen did absolutely nothing for the pain. I went back to the GP after three days of agony, for a different prescription.
Hope it works for you OP.

f1mercedesfan · 09/03/2026 08:02

thewaylifegoes · 09/03/2026 07:32

Nope, no existing issues. The doctor said it was standard to prescribe together to prevent stomach issues. I think it’s because on the days I’m not taking the naproxen, I’m to continue my usual ibuprofen and paracetamol that I was told to take in the hospital in France, and she’s being cautious.

When I was prescribed naproxen I was told never to take it with ibuprofen due to them both being in the nsaid category of pain relief and naproxen being basically a stronger version of ibuprofen. Never heard of omeprazole before, they usually say to have nsaids with food to protect the stomach lining and prevent ulcers.

firstofallimadelight · 09/03/2026 08:01

thewaylifegoes · 09/03/2026 07:37

I’m in the UK and that’s what I’ve been prescribed 🤷🏻‍♀️

Any nsaid can cause stomach issues if you are taking long term ibuprofen it’s best to take an inhibitor like omerprozle (sp) . Just take one a day as long as you are on daily ibuprofen or naproxen

SerenityScout · 09/03/2026 08:00

I haven’t taken naproxen myself, but I totally understand the health anxiety around medications and instructions. When I was dealing with anxiety, I was actually prescribed medical cannabis through LeafEase (leafease.co.uk). It’s been really helpful for managing my anxiety and the constant worrying about health stuff.

For your situation, though, it might be worth double-checking with your GP or pharmacist just to clarify the dosing, especially since the instructions on the packets seem different from what the doctor said. Pharmacists are usually great at explaining exactly how to take medications together.

thewaylifegoes · 09/03/2026 07:59

Iffytimes · 09/03/2026 07:55

It is standard practice to prescribe omeprasole or an equivalent with anti inflammatory medication.
Omeprasole first thing with first dose of naproxen and 2nd dose naproxen 12 hours later.
Am surprised the discomfort hasn’t encouraged you to start pain relief!

I’m holding off a) because of the concerns I had about the omeprazole and b) because I’ve only been given 28 naproxen tablets and I don’t want to use them all up

OP posts:
firstofallimadelight · 09/03/2026 07:58

randomchap · 09/03/2026 07:28

I took one omeprazole on the morning with breakfast and a naproxen, followed by just naproxen at dinner time.

Check with your pharmacist though

Yes exactly same. I also took paracetamol or cocodomol as directed.

Iffytimes · 09/03/2026 07:55

thewaylifegoes · 09/03/2026 07:32

Nope, no existing issues. The doctor said it was standard to prescribe together to prevent stomach issues. I think it’s because on the days I’m not taking the naproxen, I’m to continue my usual ibuprofen and paracetamol that I was told to take in the hospital in France, and she’s being cautious.

It is standard practice to prescribe omeprasole or an equivalent with anti inflammatory medication.
Omeprasole first thing with first dose of naproxen and 2nd dose naproxen 12 hours later.
Am surprised the discomfort hasn’t encouraged you to start pain relief!

VividDeer · 09/03/2026 07:50

Usually its only one omeprezole a day, unless you are really refluxing?
My naproxen says 1 to 2, so its probably based on if you need more.
I'd try and limit it personally, not easy on the stomach.
Are you taking paracetamol aswell?

SalmonOnFinnCrisp · 09/03/2026 07:48

Jist to reassure you I took Naproxen with no issues for a few weeks.

Id check with the pharmacy but id do omraz. And Nap. In the AM and Nap in PM
Both with or just after meals

RosesAndHellebores · 09/03/2026 07:47

I've taken naproxen and omeprazole many times over the years.

Naproxen is usually prescribed as a 500mcg tablet (far stronger than ibuprofen at 200mcg). It is very effective and is an anti-inflammatory. Taken twice a day.

Omeprazole is taken once a day and mitigates against the potential hardness on the tummy.

You can take the naproxen without the omeprazole and if yiur tummy gets gripey, add in the omeprazole. You are lucky your GP has prescribed them automatically.

Your GP has prescribed the same quantity of both because they come in standard side packets.

Neither drug is heavy duty, both will help you. I wouldn't hesitate to take them. They will help the pain.

I hope you feel better soon.

Mushypeasandchipstogo · 09/03/2026 07:45

After a recent knee operation I was given the omeprazole to have one, before food, in the morning. Then with food naproxen about an hour later and then one later at night. However, I was violently sick with the first naproxen in the hospital and couldn’t take them again. I had to have co-codamol instead which did the job !