Please or to access all these features

AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

To think it will be revealed WLI cause physical aging

830 replies

Tuliptana · 02/03/2026 07:14

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

OP posts:
Thread gallery
18
CreamolaFoam26 · 05/03/2026 18:36

Laskey · 05/03/2026 17:51

??? I merely shared my observation. Classy of you to suggest I need psychological intervention for sharing my opinion

Im very happy to stand by what I said, and I think you would really benefit from reading the other replies to your post quoted above as others have also picked up on your observations.

FrothyCothy · 05/03/2026 18:21

Incidentally (probably because I’ve been looking at this thread) the algorithm threw up a side profile picture of Kelly on stage at the Brits and she looks fine - very slim, yes, but fine. I’d love to go for a drink with her and Sharon, I bet they’d be a hoot and have fantastic stories to tell.

HRTQueen · 05/03/2026 18:06

I have this said to me a few times by those so concerned 🙄

I really couldn’t give a fuck I am healthier and look far better my big moon puffy face certainly puffed out my lines now they show a bit more

Kelly Osbourne is grieving in the public eye she really doesn’t need false concern over how she now looks older

DarkForces · 05/03/2026 18:01

Notsosweetcaroline · 05/03/2026 17:56

I think maybe it’s more you think your sils skin has come away from her facial muscles following about a stone and a half loss, and think the same of others. It does feel like it’s not rooted in reality.

I don’t think it’s an insult, everyone needs help sometimes.

And what 'help' is that commentary offering?

DarkForces · 05/03/2026 17:59

Laskey · 05/03/2026 17:51

??? I merely shared my observation. Classy of you to suggest I need psychological intervention for sharing my opinion

A neutral observation rarely starts with "I don't mean to be harsh but..." and ends in "no offence when to be honest, the content is both harsh and offensive. Women are not there to be objects attractive to your eye. If your observation is correct and weight loss injections turn us into 'very strange looking' 'saggy' humans at least we're healthy strange looking saggy women.

Notsosweetcaroline · 05/03/2026 17:56

Laskey · 05/03/2026 17:51

??? I merely shared my observation. Classy of you to suggest I need psychological intervention for sharing my opinion

I think maybe it’s more you think your sils skin has come away from her facial muscles following about a stone and a half loss, and think the same of others. It does feel like it’s not rooted in reality.

I don’t think it’s an insult, everyone needs help sometimes.

Laskey · 05/03/2026 17:51

CreamolaFoam26 · 05/03/2026 06:34

I think the problem lies with you. I think you’ve jaundiced yourself with regards to WLI, and it runs so deep that you can only see what you want to see.

It’s not healthy to be so obsessed with something that you are losing a grasp of reality, and you’d probably do well to step back from all things WLI for a while. Maybe even see someone, because you do seem to be obsessed with them to the point of not seeing clearly.

No offence intended. Just an observation based on your contribution to the thread.

??? I merely shared my observation. Classy of you to suggest I need psychological intervention for sharing my opinion

Nanda66 · 05/03/2026 17:45

Binus · 05/03/2026 16:50

The risks and benefits of WLIs will be the same regardless of why a person is taking them. One's feelings about fatness and gallstones don't actually make two shits of difference.

What a great point! Well said.

Calliopespa · 05/03/2026 17:34

Binus · 05/03/2026 16:50

The risks and benefits of WLIs will be the same regardless of why a person is taking them. One's feelings about fatness and gallstones don't actually make two shits of difference.

That's actually a very good point. 😄

Calliopespa · 05/03/2026 17:33

CreamolaFoam26 · 05/03/2026 16:36

I never planned to stay on WLI forever. It has only ever been about getting off them (four weeks from now) and living every day for the rest of my life as someone for whom being a healthy weight has to be a priority. My life will be lived around prioritising my health and weight. I know I can’t live forever, but I’m certainly going to give living to a ripe old age a really good go. I’m 68 now, and the longer I’m on this earth, the longer I want to be on it with my beautiful children and grandchildren.

Am I bothered by the fact that most people who lose weight on any kind of diet regain it? No, not at all. In fact, I don’t even give it a thought. The only person who matters in my life when it comes to my health and weight is me, and there is absolutely no way I’m going to let other peoples weight gain scupper me.

Love this post!

CreamolaFoam26 · 05/03/2026 16:50

Just a quickie - my vulval Lichen Sclerosus has vanished since I’ve been on WLI and I no longer use my steroid cream to treat it. And I’m told by my specialist that if they didn’t know I have it, they wouldn’t know. So whilst I have no plans to use WLI for maintenance, if after a few months off Mounjaro my LS comes back I’ll certainly reconsider microdosing to see if it keeps my LS at bay.

Binus · 05/03/2026 16:50

Boomer55 · 05/03/2026 16:19

Like most things, if a drug will help in any way, health wise, then it’s probably worth taking. If it’s just being taken for vanity, the it’s probably not being taken for the right reasons.

But, again, we all make choices.

The risks and benefits of WLIs will be the same regardless of why a person is taking them. One's feelings about fatness and gallstones don't actually make two shits of difference.

likelysuspect · 05/03/2026 16:50

😱

Golden Girls Beauty GIF
Notsosweetcaroline · 05/03/2026 16:45

likelysuspect · 05/03/2026 16:38

The word vanity is incredibly moralistic isnt it.

As I said upthread, I took the pill for reducing my facial hair. Vanity in other words.

And someone who is overweight taking this medication is taking it for a medical reason, its not ok to be overweight no matter how people might try to spin it. If they think they look better after losing weight thats also great.

I’ve done loads for vanity, I dye my hair. I wear make up. Now I’m slim I chose clothes I like and feel I look good in. Vanity, otherwise I’d shave my head and walk about in a pair of old joggers.

vanity is a moralistic word, it is used to indicate a failing of some sort in the person, like you’re committing a sin, or self engrossed or self indulgent.

im staying on wli, primarily for health, physical, but also mental. Im confident in my appearance, I enjoy getting dressed in the morning, I enjoy picking clothes to wear, the injections helps me keep that, I know I won’t gain weight, I don’t have the daily struggle any more. My clothes today will fit me next month and next year, I don’t need to struggle for that to happen.

so if part of it is vanity, then sure call me guilty, am happy to put my hand up and own it. All day. Every day.

likelysuspect · 05/03/2026 16:38

Boomer55 · 05/03/2026 16:19

Like most things, if a drug will help in any way, health wise, then it’s probably worth taking. If it’s just being taken for vanity, the it’s probably not being taken for the right reasons.

But, again, we all make choices.

The word vanity is incredibly moralistic isnt it.

As I said upthread, I took the pill for reducing my facial hair. Vanity in other words.

And someone who is overweight taking this medication is taking it for a medical reason, its not ok to be overweight no matter how people might try to spin it. If they think they look better after losing weight thats also great.

CreamolaFoam26 · 05/03/2026 16:36

I never planned to stay on WLI forever. It has only ever been about getting off them (four weeks from now) and living every day for the rest of my life as someone for whom being a healthy weight has to be a priority. My life will be lived around prioritising my health and weight. I know I can’t live forever, but I’m certainly going to give living to a ripe old age a really good go. I’m 68 now, and the longer I’m on this earth, the longer I want to be on it with my beautiful children and grandchildren.

Am I bothered by the fact that most people who lose weight on any kind of diet regain it? No, not at all. In fact, I don’t even give it a thought. The only person who matters in my life when it comes to my health and weight is me, and there is absolutely no way I’m going to let other peoples weight gain scupper me.

DarkForces · 05/03/2026 16:30

No drug is risk free. You always have to balance side effects against benefits. I can get painkillers delivered in my shopping order that I also have to use responsibly and in line with the guidance. A paracetamol overdose is lethal. Ibuprofen can wreck your stomach lining. Codeine is addictive. I'm always thoughtful about what medication I use and am not responsible for people who use them in ways that aren't recommended.

Based on the increasing evidence that glp1s reduce inflammation and decrease risks of a range of life limiting diseases beyond that of normal weight loss we may well all be microdosing in 20 years time. Or maybe despite every indication otherwise they'll have killed mr and I won't be around to hear 'I told you so'. I'll watch where the evidence takes me and listen to my body and prescriber.

These drugs have the potential to save more lives than any other I can think of except vaccines and antibiotics. They mean the people I love could be with me and healthy for longer. That's something to celebrate and just the thought of it makes me happy.

Notsosweetcaroline · 05/03/2026 16:27

Boomer55 · 05/03/2026 16:19

Like most things, if a drug will help in any way, health wise, then it’s probably worth taking. If it’s just being taken for vanity, the it’s probably not being taken for the right reasons.

But, again, we all make choices.

Why isn’t it thr right reason. Have you been fat? I can tell you it’s demoralising for most. It has a huge impact on mental health.

feeling guilty for eating, but wanting to eat, constant dieting and regaining, hiding your body in your clothing choices solely purchased to hide the rolls, feeling too hot in summer, your thighs chafing. Wanting it to be winter or autumn so you can hide behind thick clothes and tights, Not wanting to expose any skin.

Constant, daily discomfort for all those things. So if someone wants to lose the weight, for cosmetic or vanity reasons, and are eligible, I’m all for it. Just liking your appearance again, feeling confident, is a huge improvement to mental health.

and I’d thoroughly recommend them to any one eligible who may not have any weight related health issues but is uncomfortable with their appearance. For me. Thays not a wrong reason. It’s another good choice.

Binus · 05/03/2026 16:20

Binus · 05/03/2026 15:01

Perhaps you could clarify then.

Do you think that diet and exercise constitute a drug free alternative for most people and if so, do you understand that in the majority of cases this eventually fails so they'll become obese again?

@Imdunfer I'll make a new reply, as your edit was quite substantial.

You said 'I don't understand you making a huge point about how few recovered obese peple there are, because people are putting the weight back on even faster when they stop using GLPs than when they stop dieting'.

People putting the weight back on when they stop taking WLIs is a different point to the fact that ongoing WLI use is the only thing that's been shown to keep formerly obese people at a healthy BMI. All other methods have failed on a population level. Your two instructors are a minute sample size and don't refute the evidence we have in much larger cohorts. Genuinely, have you done any research at all on this or did you just think two people you know was sufficient evidence of anything at all?

That said, the science in relation to those obese people who did use WLIs then stopped is less settled than the science in relation to those who lost weight through diet and exercise. We already know, cast iron, not remotely a matter of opinion that diet and exercise usually doesn't work in the long term when a person is already obese. Whereas the recent BMJ review that found users regained at a faster weight (and also that they were still lighter than dieters at the end of the period!) said more research needed to be done. Because most of the studies they reviewed were from older rather than newer generation WLI drugs.

So we don't actually know what the newer data will say yet. Maybe it'll give better long term outcomes than diet, I don't know. Seems pretty unlikely it'll work as well as long term WLIs though. Which are the most effective tool we have.

Boomer55 · 05/03/2026 16:19

Like most things, if a drug will help in any way, health wise, then it’s probably worth taking. If it’s just being taken for vanity, the it’s probably not being taken for the right reasons.

But, again, we all make choices.

Notsosweetcaroline · 05/03/2026 16:12

Yeah me too I’m not going to be less enthusiastic, I love I’m healthy, I love my blood test results are all now healthy, I love I feel energetic and look great, I love I’m in a fit and toned body, anyone who wants me to curb thay enthusiasm, tough. My prescriber, my gp, and my family are all happy and comfortable. And I’m a grown up,

netter than slowly killing your self with wine and cake as I’m fairly sure some folks the walking worried on here are doing.

so no curbing of enthusiasm, I will continue to say how wonderful it is. Don’t like it, look away.

CreamolaFoam26 · 05/03/2026 16:06

Nanda66 · 05/03/2026 15:24

As far as I’m concerned I’m taking a legitimately prescribed drug, from a legitimate medical practitioner, for its legitimate purpose. No different to any other drug. I’ve had no side effects since the first couple of weeks, I’m eating healthily and I look and feel fantastic. End of story.

Other people’s health is no-one else’s business. So no need to be concerned about me.

I’m sure others will feel the same.

Hear hear.

we must have cross posted.

CreamolaFoam26 · 05/03/2026 16:03

Soontobesingles · 05/03/2026 14:08

I understand users of these medicines are desperate for them to be risk free for anyone to use - I simply don't agree they are, and both peer reviewed evidence and my own eyes support my view. Leaving the thread now, as have fully explored my view.

I’m not sure who’s meant by i understand users of these medicines are desperate for them to be risk free for anyone to use but if you’re meaning users of WLI are desperate for them to be risk free for anyone to use then all I can say is that you’ve just proved how ridiculous your opinions are.

Fact - I couldn’t care less about anyone else’s use of WLI though I have enjoyed the company of a few women in one of the threads here.

Do I spend time thinking about people misusing them? Absolutely not. I’m too busy getting on with an enjoying my own life.

Do I care if people use them and become ill because they’ve misused them? Absolutely not and as far as I’m concerned they’re numpties who deserve all they get.

Do I spend my time thinking about the opinions of people like yourself? No. Not all. The only attention you get from me is the length of time it takes to read your posts or reply to them. You see, you just don’t have the power you think you have when it comes to influencing me as a WLI user, and you certainly can’t read my mind so I’m at a loss as to how you think you can say what you did.

Fact - you have no relevance in, or influence on in my life whatsoever.

HeidiLite · 05/03/2026 15:33

There are plenty of people who have changed from being obese to being a healthy weight and stayed there.

There aren't though. According to studies, 90 or some studies claim even up to 99% of people who have lost weight by non-drug assisted means will regain it.

Mrsredlipstick · 05/03/2026 15:27

@MyLuckyHelper there are some ongoing trials on reducing alcohol use using GPI drugs
As up thread I only took them for a few weeks and I didn't fancy booze at all. My cousin who is alcohol dependent said the same.

Lots of obese people drink too much (the image of skinny alcoholics is far and few between). Alcohol daily is in the British diet and women are targeted with 'cheeky gins' etc.
Surely that is another benefit for the individual and their wider health?