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To think it will be revealed WLI cause physical aging

830 replies

Tuliptana · 02/03/2026 07:14

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

OP posts:
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SilenceInside · 02/03/2026 13:21

@LimeGoose people are choosing to use WLI because they cannot afford to wait for the pace of societal change to remove things like UPFs and so on, if that's even achievable. I was morbidly obese, and my health was being affected - I could not have waited for 10, 20 plus years for society to change and for that to have some effect on my weight and health. Isn't that pretty obvious?

Nellodee · 02/03/2026 13:21

I don’t see any of these jaundiced, hiv suffering, wrinkled crones around. I see people who were huffing and puffing walking round school a year ago now springing about confidently in fancy new wardrobes. Is there a word for the opposite of rose-tinted glasses?

AmandaBrotzman · 02/03/2026 13:21

inmyfashion · 02/03/2026 09:59

The increased use pancreatic cancer risk is already being noted. That alone is enough to make me never touch them - any increased risk of that deadly, horrendous disease is not worth it.

Obesity is one of the main causes of cancer though were you not aware?

LimeGoose · 02/03/2026 13:17

usedtobeaylis · 02/03/2026 12:13

Does that go for all chronic conditions or just the obesity one?

Certainly not all chronic conditions, but obesity is widespread. Why are we medicating millions of people with strong drugs, the long-term effects of which aren’t fully understood, when ultra processed food and the unethical practices of the food industry are at the root of the modern obesity epidemic?

Hobnobswantshernameback · 02/03/2026 13:17

This thread is a cesspit of medical misinformation with a lump of ableism "rather be fat than blind" and a soupçon of ageism
Imagine looking old and haggard what a terrible thing to happen, imagine how bad it would be to look old
I I mean it's a useful tool to see which posters possess utterly odious beliefs and I suspect the OP has sloped off having got exactly what they wanted from this thread

Dutchhouse14 · 02/03/2026 13:16

It depends whether aging is just looking older ie losing fat and sagging or whether its biologically aged you internally. The former is just cosmetic the later would be truly concerning.

I think Kellie and Sharon Osborne have a lot more going on than mounjaro and grief.
Anorexia? Drug/alchohol addiction? MH issues? Over use of plastic surgery?
Its really sad and i think people need to step away from unkind comments about them.as they are clearly very fragile.

Calliopespa · 02/03/2026 13:11

DarkForces · 02/03/2026 09:54

And that's fine. They aren't compulsory. But your preferences and assumptions don't make any difference to the evidence that being a healthy weight and on wlis is less risky than being obese.

I think that is probably the bottom line - and I suspect much of the talk around being fearful of them is coming from people who are not themselves obese so don't need to consider taking them.

I do think it is more than the (peculiarly childish) suggestion that "people are jealous the fatties aren't still fat and they haven't got their "advantage any longer."

I say that because in all honesty I have noticed a different look from just "depuffed skin" in people I know who have used WLI and I cannot pretend the best description isn't that it looks a bit like illness - a sort of sallow colour and a different pattern to the face gauntness, which could be something to do with the liver trying to keep up with processing the medication or similar.

BUT I am not obese and my weight isn't affecting my health, and so I am not in a position to judge how much I would be prepared to overlook that for what are often almost certainly health gains on other metrics.

Sarah24x · 02/03/2026 13:07

My ex is an overweight doctor who used to work in a diabetic clinic.

He used to say he would never use WLI as they can cause pancreatic problems

Nellodee · 02/03/2026 13:03

I love wli. My husband assures me I look about 15 years younger than this time last year. My daughters glaze me constantly about how young I look and how surprised their friends are when I tell them my age. According to my students, I had a massive “glow up” over last summer.

For me, my main worry about these drugs is that losing is easy, maintenance is haaaaaaard. It was great, upping the dose, looking better, feeling great and watching those scales go down, down, down. I did everything right, eating lots of protein, starting a weight lifting habit.

Now I’m maintaining at 9 st 3, somehow still a 12/14 at bmi 22. But there’s part of me thinking, “My MeThreeSixty scan looks even better with another stone off…” I’ve very slowly moved down from 7.5mg to 4mg, trying to see how low I can go before the weight starts creeping back on, but I do have those thoughts of, “What if I just kept going a little further?”

If you’d have told me at 13 stone that I’d be hitting 9st3 and still thinking I could lose another half a stone, I’d have said you were crazy. My original target was 10 stone. I’ve always been a hairy legged feminist type and wouldn’t have thought I would be vulnerable to the appeal of weight loss beyond its health implications, but I still feel that tug towards wanting to be just one dress size lower (a size 10 isn’t super skinny, is it?)

I think wli are relatively new, and lots of people are still on their journeys. I think we’ll probably see that a few people will really struggle to stop that journey at the other end.

OP is talking bollocks, mind.

fivepastmidnight · 02/03/2026 12:54

Sharon Osbourne has been pretty open about the things she's done for weight loss - surgery /ozempic. She said that she couldn't stop losing weight even when she stopped with the ozempic . At the time she was saying that she wished she hadn't used it ,Kelly was very much still in favour. She was very slim but not like she is now . I wonder if Kelly is having a similar response in that she might have stopped using but the weight loss is continuing . As well as the Ozempic face that they both have, Kelly's clearly had some sort of surgery to her face because her whole jaw is completely different .When she lost weight originally, her face was much slimmer but she still had that distinctive jaw . I think I think when people lose a lot of weight, whatever the method, unless you're a teenager or early 20s it does look ageing. I think a lot of the overweight /obese people look younger 'cause their faces are plumped out. I've lost weight and I've lost my double chin but now I have a more scrawny neck. When I lost weight in my 20s there was no negative impact on my face.

my cholesterol is lower ,i'm no longer pre diabetic, My knees don't hurt, I can exercise for longer so will take that over the scrawny neck. Decades ago I felt much more confident of injections safety. In present day I don't have that same confidence about almost any injection ,in terms of the quality of the safety testing Or the knowing of the long term impact. You can just inform yourself as well as you can. I do think a lot of people who are totally anti weight loss injections have no real idea about the difficulties people have losing weight and much of the time go off headlines for their information.

CautiousLurker2 · 02/03/2026 12:50

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OMG you need to just stop.

I am in my late 50’s but now look ten years younger. Possibly because I smile more - I am happier, fitter and getting out doing things again, so take care of my appearance. I am more confident which is better than any botox or face creams on your appearance. I get chatted up at the bar by younger men, people hold doors open again, the traffic stops to let me cross (NEVER did that before I lost weight - I was the fat, older, not-worthy-of-notice woman who was thus rendered invisible). I wouldn’t say I’m beautiful in anyway, [my DH, bless him, would disagree] but I’m definitely more attractive and attract attention again. And I definitely don’t look as though I have HIV.

Again, if you are taking a pop at a) an elderly woman in her 70’s who has just lost the love of her life after decades of struggling with his MH or b) a 41yo woman with an severe eating disorder, multiple MH issues which triggered alcohol and drug addiction in her youth and who is ALSO grieving for the dad she adored, then, frankly this is just a display of despicable internalised misogyny. I bet you’re no oil painting either, so just leave these women alone and butt out of the medical and health decisions of other men and women when you clearly know fuck all about the treatments or the conditions.

Notsosweetcaroline · 02/03/2026 12:42

MO0N · 02/03/2026 12:20

You're really hoping for a big sting in the tail aren't you @Tuliptana

She’s not alone in wishing for it. I find this thread abhorrent as it uses a woman who has said she’s mentally in a very bad place, and it’s nothing to do with medication, but I saw a comment from someone on another thread like this where they wrote they couldn’t wait for everyone to get cancer.

it feels like as they can’t get the drugs, they want some ill to befall those who can. Looking older seems to be the mantra of choice right now. Where so many before and afters are available on line, shows people look overwhelmingly more youthful, as weight in itself is ageing, obesity is our biggest killer.

i think for people like the op it’s about appearance, people getting slim, they can’t see the health benefits of a healthy population, or they don’t care, they just care that women, and it’s always about other women, can get slim with these meds and they can’t.

usedtobeaylis · 02/03/2026 12:23

I don't really care about how old I look. Did I look younger when it wasn't clear where my face ended and my neck began and my face was all cushiony and squidgy, yes. Do I look older now that my jaw and wrinkles have emerged from that, yes. But I look older compared to how I did, not compared to my age. I look my age. I'm approaching 50, what am I supposed to look like? I'm not supposed to look like I'm in my 30s. And so what? I don't hobble like an old woman, and my lower legs don't splay outwards when I stand still because of the fat on my thighs, I can walk up stairs and see my wrists, I can run, I can sleep flat like a normal person instead of propped upright. Who cares how I look when I can live.

MO0N · 02/03/2026 12:20

You're really hoping for a big sting in the tail aren't you @Tuliptana

PIPquestioner · 02/03/2026 12:20

Someone who was once a friend and used that friendship to lull me into a false sense of security before she shafted me, was very very obese. She is now on WLI and has lost a lot of weight and looks haggard, like an old woman.

I am so fucking delighted.

Face or figure, isn't that what they say?

Notsosweetcaroline · 02/03/2026 12:16

The envy is off the scale isn’t it. I can’t believe anyone thinks by bitching about Kelly Osbourne they are saving young girls lives. I feel so awful for Kelly. That people do this. Won’t accept she’s unwell due to their extreme envy of people on the drugs.

the fact remains, scientifically proven the drugs are anti ageing, and trials either under way or about to be to test that further due to the huge benefit on us as humans.

but let’s all pick on a woman mentally struggling and proclaim to be saving lives by doing so,

fucking shameful.

Oakcupboard · 02/03/2026 12:14

You know what they say - obese don’t crease, so when u loose weight that padding leaves.

I’ve lost 8 stone with WLI and although I can notice my nasiolabial folds & marionette lines more pronounced I also look younger than I did, bizarrely. I suppose l look less fuddy duddy.

I’ve also been been assumed to be my teenage son’s sister (now I’m well aware that’s because of the drastic height difference but I’m going to pretend that it’s because it’s because of my face 🤪)

edited to add my resting heart rate has dropped from 110 to 65, my sleep apnea is gone and I have my diabetes is in remission. Apparently I have added about 14 years onto my life and I’ve decreased my risk for certain cancers

usedtobeaylis · 02/03/2026 12:13

LimeGoose · 02/03/2026 11:37

I don’t dispute that, but I also don’t think huge numbers of people becoming medical patients for life is necessarily going to end well. My mum died of pancreatic cancer in her early 60s so I don’t take it lightly.

Does that go for all chronic conditions or just the obesity one?

usedtobeaylis · 02/03/2026 12:12

Bearsdolovetrees · 02/03/2026 11:36

There are plenty of studies on what WLI do to the internal organs. They improve liver and heart function for one. And there’s a whole host of other improvements. It’s all there for you to just research/ look up rather than postulating ridiculously uninformed and speculative views…..bizarre.

They also incredibly good at targeting abdominal visceral fat - dangerous fat that women in particular find very difficult to lose. Which includes visceral fat around the pancreas, that organ that people didn't give a shit about until they could start talking breathlessly about pancreatitis in such a truly concerned way.

Bumbelinaaa · 02/03/2026 12:12

Tuliptana · 02/03/2026 07:48

Sorry but no if it starts a discussion and stops young women abusing weight loss medication that was never developed for them , then it might just save a few lives.

Its almost as if no one wamts to talk about the elephant in the room..

Wow. Thank goodness you’re saving the world by starting this groundbreaking and completely original thread about WLI. Because it definitely doesn’t come up at least once a day on Mumsnet.

Trust me OP, this “elephant” is discussed constantly, usually with the same generous side of faux concern.

SilenceInside · 02/03/2026 11:46

@LimeGoose by “medical patients for life” what do you mean? Do you mean people taking WLI for life? Or something else?

Either way, you are not considering that people who are obese are already at higher risk or already are “medical patients” for life. Losing weight via taking WLI decreases their overall risk of serious health implications, it doesn’t increase it.

FurForksSake · 02/03/2026 11:40

@LimeGoose my mil is currently dying from it. It’s awful. I’m sorry for your loss.

Bearsdolovetrees · 02/03/2026 11:38

Tuliptana · 02/03/2026 07:48

Sorry but no if it starts a discussion and stops young women abusing weight loss medication that was never developed for them , then it might just save a few lives.

Its almost as if no one wamts to talk about the elephant in the room..

Oh my mistake. Op just wants to save poor young girls lives. As they’re dying in droves…obviously

LimeGoose · 02/03/2026 11:37

FurForksSake · 02/03/2026 11:00

Chronic gallstones and pancreatitis increase the risk of biliary cancers. This is due to the chronic inflammation associated with the chronic nature of the illnesses. There is a small increase chance of pancreatitis and gallstones which could lead to an increase risk in cancers if those illness s became chronic. The risk appears to be for acute though.

And all that is really conjecture on the amount of increased risk.

what we do have solid evidence for is the risk of obesity, poor diet, smoking and diabetes. They are known risk factors. So if we control the diabetes and the obesity the risk is more than likely overall lower.

I don’t dispute that, but I also don’t think huge numbers of people becoming medical patients for life is necessarily going to end well. My mum died of pancreatic cancer in her early 60s so I don’t take it lightly.

Bearsdolovetrees · 02/03/2026 11:36

Tuliptana · 02/03/2026 07:21

Yes but its not just a 'bit older' its drastic aging which makes you wonder what its doing to internal organs. It seems more profound in women who were not obese to start with but used them anyway.
I guess it could be lack of nutrition or dehydration but the effects are scary.

There are plenty of studies on what WLI do to the internal organs. They improve liver and heart function for one. And there’s a whole host of other improvements. It’s all there for you to just research/ look up rather than postulating ridiculously uninformed and speculative views…..bizarre.