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Original poster

To think it will be revealed WLI cause physical aging

830 replies

Tuliptana · 02/03/2026 07:14

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

OP posts:
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milkyuniverse · 02/03/2026 23:55

janedoe26 · 02/03/2026 07:18

Their skin has lost fat that was plumping it up- therefore sagged a bit. Preferable to obesity and all its related conditions for longevity for most people. So no, not ‘physical aging’ on a global level it’s going to increase lifespan. Cosmetic ageing, perhaps. I know which I would choose.

Actually, there is more to it than that. I was listening to a plastic surgeon talking about the difference in the internal tissue of people on WLI. It's more "friable" I think he said. Other general surgeons he'd talked to had also encountered this when operating on internal organs. It has a markedly different texture and strength and is difficult to operate on.

GoneBackToTheWorld · 02/03/2026 23:48

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Fishingboatbobbingnight · 02/03/2026 23:48

Well I lost 8 stone and have been told a huge amount of times how I haven’t just lost weight but about 20 years. My health is back to where it was 20 years ago in terms of blood pressure, cholesterol etc.. so I have no regrets and plan to stay on it.

Oohd · 02/03/2026 23:36

Well I have been using WLI for about 10 months. Have lost about 2 stone and feel so much fitter ie not breathless walking up hills,joints not painful etc .
Yes my neck has aged ,but can deal with that over looking fat !

likelysuspect · 02/03/2026 23:18

Since WLI have come along Ive never read so many opinions and apparent 'facts' about how losing weight will shorten your life, because of course fatties will nearly always lose weight the 'wrong' way, Cambridge diet, calorie counting, SW, WW, keto, low carb, low fat, we're just all wrong all round.

So now WLI are the new 'wrong' way to lose weight hastening our demise much much faster than a nice thick cloak of yellow fat around our internal organs ever will

Ukefluke · 02/03/2026 23:12

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Not as much as visceral fat will.

Ukefluke · 02/03/2026 23:11

Tuliptana · 02/03/2026 07:21

Yes but its not just a 'bit older' its drastic aging which makes you wonder what its doing to internal organs. It seems more profound in women who were not obese to start with but used them anyway.
I guess it could be lack of nutrition or dehydration but the effects are scary.

Seriously, you extrapolate from people looking older because they have lost facial fat......to WLI making doing something bad to internal organs...(which dont have skin incidentally).

As well as losing facial fat, people on WLI will also lose visceral fat.

Visceral fat is the very worst most dangerous kind which coats internal organs. High visceral fat is an indicator of likely early death due to Type 2 diabetes, heart disease, stroke, high blood pressure, cancer, dementia, Alzheimer's and many others.

In reducing it, people on WLI are preserving their internal organs and increasing their life expectancy.

DancingNotDrowning · 02/03/2026 23:08

Imdunfer · 02/03/2026 08:17

There is no longevity data at all. A million times one year is not a million years of data for a medication trial.

And the data that exists is for people being medically monitored, not for people who bought it from an online chemist, many by lying.

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How are you defining longevity data?

Early GLP-1s started human trials in the 90s - 25 years of safer data is usually considered compelling.

tobee · 02/03/2026 23:04

It sounds like you know fuck all op. But it’s always fun to do a bit of speculative scare mongering mixed in with moral superiority isn’t it? I’m not sure you really know anyone who is on wli.

And there is no elephant in the room. Just another tedious load of crap from on op who hasn’t bothered to come back to their own thread for hours.

🥱

Ukefluke · 02/03/2026 22:58

Oh bore off.

EvangelicalAboutButteredToast · 02/03/2026 22:58

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Yep. Add age to any of the differentials and it’s maximising the effect.

DarkForces · 02/03/2026 22:45

EvangelicalAboutButteredToast · 02/03/2026 22:36

Who is that provider please if you don’t mind me asking?

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I use oushk but there's lots of options of regulated pharmacies offering maintenance at monj.co.uk/mounjaro-maintenance-pharmacies/

GoneBackToTheWorld · 02/03/2026 22:37

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EvangelicalAboutButteredToast · 02/03/2026 22:36

DarkForces · 02/03/2026 22:34

We've decided that an investment in my health is worth every penny. I'm not in a clinical trial. I'm just on a normal private prescription with a supplier that supports long term tailored maintenance

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Who is that provider please if you don’t mind me asking?

EvangelicalAboutButteredToast · 02/03/2026 22:35

Massive weight loss is ageing.
Being significantly underweight is ageing.
Being significantly overweight is ageing.

DarkForces · 02/03/2026 22:34

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We've decided that an investment in my health is worth every penny. I'm not in a clinical trial. I'm just on a normal private prescription with a supplier that supports long term tailored maintenance

BeAvidHiker · 02/03/2026 22:33

Being overweight makes you look older. Always.

likelysuspect · 02/03/2026 22:32

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If she's in a diabetes clinic, why are her patients coming off the jabs, they're prescribed for diabetes? My OH wont come off his, hes been on them for nearly 20 years.

In terms of weight loss whats her solution to losing weight then, her own and society at large (no pun intended). Just to stay fat in case you put the weight back on?

tutugogo · 02/03/2026 22:30

The speed of the loss is potentially an issue, if you loose slowly but steadily your skin can adjust to a certain extent.

TheBroonOneAndTheWhiteOne · 02/03/2026 22:28

Tuliptana · 02/03/2026 07:23

Its really not. Each to their own. I just think its becoming more apparent.

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And when is the medical establishment going to fund your professional research into the subject?

GoneBackToTheWorld · 02/03/2026 22:26

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WhenWillItBeSpringAgain · 02/03/2026 22:20

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If she’s “a little bit overweight” then she wouldn’t be prescribed them so I’m relieved to hear that, as a nurse, she’s not planning to go down the black market route.

SilenceInside · 02/03/2026 22:17

If she’s only a little bit overweight @GoneBackToTheWorld then she wouldn’t meet the prescribing criteria and so taking an anti-obesity medication when you’re not obese would be an odd choice. Never mind the apocryphal tales of all the patients piling the weight back on as soon as they stop. I do wonder why diabetics would stop taking a GLP1 if it’s controlling their blood sugars though. Seems a bit unusual to me.

DarkForces · 02/03/2026 22:16

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Which is why maintenance dosing is available and exactly what I am doing. I work for the nhs and a lot of my colleagues who are at the very top of their clinical career are on wlis alongside me.

GoneBackToTheWorld · 02/03/2026 22:16

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