Please or to access all these features

AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

To think it will be revealed WLI cause physical aging

830 replies

Tuliptana · 02/03/2026 07:14

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

OP posts:
Thread gallery
18
JustSawJohnny · 03/03/2026 10:17

Notsosweetcaroline · 03/03/2026 07:36

Please leave these women alone. Stop attacking their appearance. Use one of the millions of other people on them. If you need someone famous try Serena Williams. Sharon is elderly, she’s previously suffered cancer, she’s grieving, Kelly has never once said ghe drugs rendered her unable to eat, she’s asking people to leave her alone, her father died and she’s struggling.

shame on you. Absolute shame of it.

I'm not attacking her, I like her.

I feel massive empathy for her and genuinely worry that she's slipped into an eating disorder.

And yes, both she and Sharon HAVE said in interviews that even after coming of Ozempic they are really struggling to eat!

You don't get to gatekeep people's comments or intentions or tell people they cannot talk about Kelly, especially on a board in which SHE WAS NAME CHECKED IN THE ORIGINAL POST!

Get over yourself.

FurForksSake · 03/03/2026 10:15

I was asked to stop a week before surgery, which I did. I then also did an extended fast for solid food. Anaesthetist was delighted with that. No need for a rapid sequence induction, just a massive dose of sedatives (they don’t work on me) and then usual anaesthesia. I went home four hours post surgery after my blood pressure recovered.

Last time I had the same surgery and after a different surgery I was supposed to be a day case and had to stay in due to post surgical tachycardia and it would not resolve. So losing six stone definitely made operations easier.

JHound · 03/03/2026 10:13

Calliopespa · 03/03/2026 09:55

I think it is your response to that poster that is the sort of reason the WLI are getting pushback though.

As I see it, they are an option, and for people who have very real health issues and plenty of reasons the weight loss is hard - and it CAN be complicated; I have good friends who have had weight battles and I am fully on their side that there wasn't an easy fix through traditional weight loss methods - I think they are a godsend.

However, not everybody's situation is the same, and for many people, especially with only a little to lose, diet and exercise can actually work and, as I see it, should be the first line of attack. It is the idea that that is now somehow outdated and ridiculous that I think people see as the dark side of the WLI.

I just think everyone should make their decisions based on their situation - and we can never really judge that from the outside.

It is the polarised positions - it is cheating, they are absolutely too dangerous regardless of the user's current obesity-related dangers vs they are essential and anyone who raises even the slightest misgiving is simply a jealous naysayer who has zero understanding of science - that are likely to lead to an unhealthy discussion around them.

The truth, as ever, is likely to sit somewhere in the middle: they can be useful in the right circumstances where clear benefit outweighs any misgivings.

But I don't think poo-pooing healthy diet and exercise is a reasonable standpoint.

Edited

Ignore me - I misread.

Blueskiesnotgrey · 03/03/2026 10:12

Clearly WLI are going to be beneficial to very overweight people, and diabetics. The health risks from being overweight outweigh the side efects of the drug. But i know a lot of women using them who weren't overweight to start with, or who just wanted to lose a stone, and I really dont think the cost/benefit stacks up there. They all look very unwell, wheras the very overweight people who have lost a lot using them look better/fine and are feeling the benefit in terms of being able to move around much better. The slim women are now looking skeletal, 10 years older, and seem to be having trouble moving. I think these drugs should only be used by people who will really benefit from them and whose hormonal/blood sugar is already out of kilter i.e obese or diabetic people. That is what they were designed for and taking them if you're not in that category is going to cause problems down the line I think.

JHound · 03/03/2026 10:10

CreamolaFoam26 · 03/03/2026 09:59

It’s taken me 18 months to lose 29kgs on Mounjaro and if it had aged me (it hadn’t) I couldnt have cared less now that Im no longer on BP medication, pre diabetes medication and statins. My blood results are at the fantastic side of normal and I think it means my internal organs are working really well. Saggy skin, I’m 68, is a tiny price to pay for all of the health benefits that’s come with my weight loss.

Edited

I am only 2 months in so a long way to go (also not found right dose for me. But a friend has lost 20kg so far on Wegovy and the improvements to her health, joint pain, and reversing her pre-diabetes matter more to her than looking older (she does not).

The passionate hatred for WLIs needs to be studied in a lab.

CreamolaFoam26 · 03/03/2026 10:07

Darlingx · 03/03/2026 10:02

Currently in the states I am told you are advised to stop the medication a month before surgery is this the case ?

Where I am it’s one week as it supposedly keeps you safer during a general anaesthetic - seemingly your intestine isn’t so full and there’s less chance of swelling your own vomit. But I’m sure someone else can explain it better than I have.

GnomeDePlume · 03/03/2026 10:04

My DM, T2 diabetic, obese for most of her life is now in the final stage of vascular dementia. Part of my motivation for getting my own diabetes under control and lose weight was to try to avoid dementia.

Dementia is hell, not just for the sufferer but also for their family. As it progresses, the person you love disappears. The person you are left with may be fearful, angry, vicious, violent. My DM has been through all of these. Now all we have left is a barely recogniseable person, doubly incontinent, mostly asleep. No quality of life. If my dog was like this I would have him pts but humans have to suffer on.

I am taking mounjaro and doing what I can to avoid my DCs having to watch me go the same way.

JHound · 03/03/2026 10:03

Calliopespa · 03/03/2026 09:55

I think it is your response to that poster that is the sort of reason the WLI are getting pushback though.

As I see it, they are an option, and for people who have very real health issues and plenty of reasons the weight loss is hard - and it CAN be complicated; I have good friends who have had weight battles and I am fully on their side that there wasn't an easy fix through traditional weight loss methods - I think they are a godsend.

However, not everybody's situation is the same, and for many people, especially with only a little to lose, diet and exercise can actually work and, as I see it, should be the first line of attack. It is the idea that that is now somehow outdated and ridiculous that I think people see as the dark side of the WLI.

I just think everyone should make their decisions based on their situation - and we can never really judge that from the outside.

It is the polarised positions - it is cheating, they are absolutely too dangerous regardless of the user's current obesity-related dangers vs they are essential and anyone who raises even the slightest misgiving is simply a jealous naysayer who has zero understanding of science - that are likely to lead to an unhealthy discussion around them.

The truth, as ever, is likely to sit somewhere in the middle: they can be useful in the right circumstances where clear benefit outweighs any misgivings.

But I don't think poo-pooing healthy diet and exercise is a reasonable standpoint.

Edited

Nobody poopoos healthy diet and exercise.

You still need to do both on GLPs. But the WLI simply removes the physiological impacts that makes this nigh on impossible for most people with obesity.

Darlingx · 03/03/2026 10:02

Currently in the states I am told you are advised to stop the medication a month before surgery is this the case ?

JHound · 03/03/2026 10:01

Sarah24x · 02/03/2026 16:36

Maybe instead of your ignorant reply trying to be funny, go and research the effects WLI can have on the pancreas.

Eat a calorie deficit, you will lose weight. It’s quite simple. I say that as someone who has pcos and lost 30kg and kept it off.

Oh yes that simple. Ignore research, the studies on obesity, of the physiological and hormonal changes it causes.

Ignore the body changes obesity caused that makes weight loss almost impossible for so may people.

A MN has spoken and shared the never before shared knowledge that all you need to do is be in a calorie deficit .

Whodathunk?!

Coming up next she shares how alcoholics should just drink less, smokers should just not smoke and junkies should just not take drugs.

And for investors just but low, sell high and you will make money.

SIMPLE!

CreamolaFoam26 · 03/03/2026 09:59

Tuliptana · 02/03/2026 07:21

Yes but its not just a 'bit older' its drastic aging which makes you wonder what its doing to internal organs. It seems more profound in women who were not obese to start with but used them anyway.
I guess it could be lack of nutrition or dehydration but the effects are scary.

It’s taken me 18 months to lose 29kgs on Mounjaro and if it had aged me (it hadn’t) I couldnt have cared less now that Im no longer on BP medication, pre diabetes medication and statins. My blood results are at the fantastic side of normal and I think it means my internal organs are working really well. Saggy skin, I’m 68, is a tiny price to pay for all of the health benefits that’s come with my weight loss.

JHound · 03/03/2026 09:56

Imdunfer · 03/03/2026 09:18

You didn't look very far, this took me one search to find.

pmc.ncbi.nlm.nih.gov/articles/PMC10213739/

Did you bother to read the link?

It has nothing to do with surgeons observations on operating on humans internal organs and everything to do with GLPs increasing intestinal length in rats and mice.

Something which has NOT been observed in humans.

Calliopespa · 03/03/2026 09:55

Bearsdolovetrees · 02/03/2026 21:55

Oh mate. Embarrassing!

I think it is your response to that poster that is the sort of reason the WLI are getting pushback though.

As I see it, they are an option, and for people who have very real health issues and plenty of reasons the weight loss is hard - and it CAN be complicated; I have good friends who have had weight battles and I am fully on their side that there wasn't an easy fix through traditional weight loss methods - I think they are a godsend.

However, not everybody's situation is the same, and for many people, especially with only a little to lose, diet and exercise can actually work and, as I see it, should be the first line of attack. It is the idea that that is now somehow outdated and ridiculous that I think people see as the dark side of the WLI.

I just think everyone should make their decisions based on their situation - and we can never really judge that from the outside.

It is the polarised positions - it is cheating, they are absolutely too dangerous regardless of the user's current obesity-related dangers vs they are essential and anyone who raises even the slightest misgiving is simply a jealous naysayer who has zero understanding of science - that are likely to lead to an unhealthy discussion around them.

The truth, as ever, is likely to sit somewhere in the middle: they can be useful in the right circumstances where clear benefit outweighs any misgivings.

But I don't think poo-pooing healthy diet and exercise is a reasonable standpoint.

JHound · 03/03/2026 09:54

milkyuniverse · 02/03/2026 23:55

Actually, there is more to it than that. I was listening to a plastic surgeon talking about the difference in the internal tissue of people on WLI. It's more "friable" I think he said. Other general surgeons he'd talked to had also encountered this when operating on internal organs. It has a markedly different texture and strength and is difficult to operate on.

Sure they said this.

Imdunfer · 03/03/2026 09:49

DarkForces · 03/03/2026 09:40

Also being obese is a major risk in surgeries

That is true but GLPs are not the only way of addressing that problem, it isn't an either/or issue.

Imdunfer · 03/03/2026 09:48

DarkForces · 03/03/2026 09:35

That's a letter to editor. I was looking for a peer reviewed paper. It appears to be about intestinal issues

Edited

I found it in one minute, I'll bet there's more. It's in the archive of the National Library of Medicine. It's a bit much to write it off as a "letter to the editor" as of it was the Daily Mail, when it contains two pages of detail, charts and graphs and ends with a warning to medics to look out for problems with the small intestine in humans on GLPs.

DarkForces · 03/03/2026 09:40

Also being obese is a major risk in surgeries

DarkForces · 03/03/2026 09:35

Imdunfer · 03/03/2026 09:18

You didn't look very far, this took me one search to find.

pmc.ncbi.nlm.nih.gov/articles/PMC10213739/

That's a letter to editor. I was looking for a peer reviewed paper. It appears to be about intestinal issues

Imdunfer · 03/03/2026 09:18

DarkForces · 03/03/2026 09:15

I can't find a single reference to back this up.

You didn't look very far, this took me one search to find.

pmc.ncbi.nlm.nih.gov/articles/PMC10213739/

DarkForces · 03/03/2026 09:15

milkyuniverse · 02/03/2026 23:55

Actually, there is more to it than that. I was listening to a plastic surgeon talking about the difference in the internal tissue of people on WLI. It's more "friable" I think he said. Other general surgeons he'd talked to had also encountered this when operating on internal organs. It has a markedly different texture and strength and is difficult to operate on.

I can't find a single reference to back this up.

Notsosweetcaroline · 03/03/2026 07:36

JustSawJohnny · 03/03/2026 00:21

Women of a certain age who lose weight fast commonly suffer skin sagging.

Kelly O has been on injections the public can't get in the UK (Ozempic) and both she and Sharon have claimed that their ability to eat has been permanently/long term affected by it.

I know they've been through a lot this year but Kelly has to be either telling the truth about her inability to eat or is still on the injections because God love her she looks really ill.

She looks older than her Mum at 41.

It's really very sad.

Please leave these women alone. Stop attacking their appearance. Use one of the millions of other people on them. If you need someone famous try Serena Williams. Sharon is elderly, she’s previously suffered cancer, she’s grieving, Kelly has never once said ghe drugs rendered her unable to eat, she’s asking people to leave her alone, her father died and she’s struggling.

shame on you. Absolute shame of it.

JustSawJohnny · 03/03/2026 00:22

Fishingboatbobbingnight · 02/03/2026 23:48

Well I lost 8 stone and have been told a huge amount of times how I haven’t just lost weight but about 20 years. My health is back to where it was 20 years ago in terms of blood pressure, cholesterol etc.. so I have no regrets and plan to stay on it.

I think it looks worse on her because she didn't have much to lose.

It's clearly gone too far, in her case.

JustSawJohnny · 03/03/2026 00:21

Women of a certain age who lose weight fast commonly suffer skin sagging.

Kelly O has been on injections the public can't get in the UK (Ozempic) and both she and Sharon have claimed that their ability to eat has been permanently/long term affected by it.

I know they've been through a lot this year but Kelly has to be either telling the truth about her inability to eat or is still on the injections because God love her she looks really ill.

She looks older than her Mum at 41.

It's really very sad.

likelysuspect · 02/03/2026 23:58

This reply has been deleted

This has been deleted by MNHQ for breaking our Talk Guidelines.

Obese people get osteoporosis you know, my friend is one of them.

Swipe left for the next trending thread