To think it will be revealed WLI cause physical aging

It is notoriously difficult to guess someone’s weight, chubby can be obese. We see it on here all the time, overweight told they look slim, healthy weight models claimed as underweight, people have lost sight of what obesity looks like. It is chubby for most people.

and you’ve misinterpreted the info on the health benefits of being over weight as we age, it can protect against ailments such as osteoporosis but the dangers of it remain, they don’t go away as we are older, so needs to be offset by the risk of heart attack, stroke, diabetes, joint degradation, fatty liver, high blood pressure, high cholesterol etc.

im always surprised people seem to think as we age the risks go away, they do not. If anything they escalate, and it’s a personal decision if you wish to take all those risks to have the small benefit of potential osteoporosis protection, which isn’t even a given,

While variations will exists, I find it unusual that someone would know so many people obtaining the drug deceptively.

Couldn't agree more. 👏

You can’t lump everyone together like that. I’ve lost a couple of stone, with one more to go on WLIs. It’s taken 9
months so far. I don’t want to lose any more than another stone because I’m in my late 50s and I don’t think being too thin would look good. I’m not in a rush, my aim is to be slim and healthy going into my 60s. I have no health conditions and all blood tests are fine, but I feel lighter, fitter and more confident. I wasn’t massively overweight but I feel better in every way and people have commented on it.

Yes, there are people on WLIs who are basically losing weight by starving themselves and it’s not good. But neither is any sort of extreme diet and that isn’t everyone. There are many people using them as an aid to weight loss and changing their lifestyle and eating habits. That’s a good thing and to suggest it’s doing damage to internal organs based on no evidence is just nonsense.

Why would I lie? I dont really care either way. I wouldnt take them myself, due to my scientific background, although I need to lose a couple of stone, am trying the gym, but my mother is a T2 diabetic and I have obese family members whose lives are severely curtailed by their weight so I think it is great they have been developed, for those people. I can't universally get behind them though when I hear people, who have no idea about how they work or the mechanism of action, talking about them like they're an illegal drug and competing to go from a size 10/12 to a size 6/8.

Indeed, and only one of whom was actually overweight. Maybe its a regional thing. They are certainly being used 'for the last stone' where I live outside London. People are very up front about it too, which I initially found strange.

Not yet, no.

Are you aware of how much medical research for humans is done on rodents because they're a good match?

The letter ends with an explicit warning to doctors to watch out for problems with the small intestine in humans.

I’m on WLI having tried every other intervention via GP although self-funded. I was 4 stone over a “normal” BMI and have v high Blood pressure, cholesterol and teetering on pre-diabetes. I am pretty fit and have a good resting heart rate rate. I am losing weight to reduce my health co-morbidities and hopefully I can reverse them and come off medication. If that happens before I hit a “normal” BMI then I shall stop the jabs. I’m in WLI groups and at least half of the people are using WLI for health reasons. I also think that the media bash women for every reason known to man, too fat, too thin, too fertile, not fertile enough, not pretty enough, etc. It’s horrible and I totally understand that the other half of people on WLI feel the pressure of other people’s judgements badly.
Being a woman isn’t easy, is it, eh?!

I don't think she is lying. Demographic variation is real.

the information is there, it isn’t a Wild West with thick fat people needing to be told how to eat properly.

I don't think these are the people the pp was referring to...

She said most were, at most, chubby. Chubby isn't actually much of a health risk - and in fact some studies suggest it is healthier past a certain age. As a society we would do well to leave space for that in our attitudes.

That’s unusual considering if we look at the overweight population 90 percent of people are not on them. Yet you know about a dozen,

I’ve used several pharmacies, and all provide info on health eating and dieting. Most people can access the internet. Nearly every fat person has tried every diet going before using wli. The injections are last resort not first resort.

being fat doesn’t make people uneducated , it doesn’t mean they don’t know how to eat properly, in fact look at any thread on here or Reddit and you’d see the overwhelming majority eat healthy balanced diets. Protein prioritisation is well publicised.

the information is there, it isn’t a Wild West with thick fat people needing to be told how to eat properly. If people have eating disorders they’d have to lie to get the drug, as they are not prescribable to anyone who has an eating disorder. An eating disorder is a known mental illness, it is not why people in the main are fat.

so yes some people lie to get the drugs, about their weight, their mental health etc, but with so many obese people out there, it is a small minority and it is far from the Wild West for anyone legitimately on the drug.

Try the Royal Borough of K and C! It's a hotbed of people who pay to get whatever they want to be as competitive on every front as they can!

Honestly, the ones I know look skeletal.

@Notsosweetcaroline another one for the potential benefits list:

There is anecdotal data suggesting that mounjaro helps with PCOS related infertility. Not simply as a result of weightloss.

Interesting. I could name 7 off the top of my head from my immediate circle of fellow parents from school and kids clubs. If I thought about people I work with, probably another 4 or 5. Oh there's a guy in my poker club as well plus the school secretary at one of my kids schools, she was overweight to start with though. The others weren't but some were slightly chubby. None of these people were obese. The ones from school swap pens and get each other pens from their online source, which I think means they are not under medical supervision, which sounds incredibly foolish to me, as someone that understands how the endocrine system works.

Im not against this medication at all, as I've said, for obese and diabetic people. I do think it is being incredibly abused on the grey market though and it will inevitably lead to unintended side effects in those people.

@CreamolaFoam26 waves!! Hello, I’m well (relatively speaking 🤣) hope you are doing well. It’s so hard to decide on an end point and it sounds like you’ve made a really good choice. I dropped my end weight several times and I’m now definitely at a point where I wouldn’t want to go lower. I like being a size 6 in jeans so I’ll stay here for a while, but know it’s not forever.

I was wondering the exact same. I only know of 1 person taking WLI, and she is doing fantastically well and looking great. I certainly don't know / work with any non-overweight people who are miracualously getting thinner or looking skeletal and 10 years older - must mix with a different demographic!

@FurForksSake how are you? I was on the Auggie thread with you. I never intended to get to even the top of what’s referred to as a healthy BMI as I knew I’d be too thin. I’m currently about 4kgs away from it and I’m maintaining now but once I reached my initial target of 85kgs I went down another 5 to 80 and that’s where I’m staying.

I hope youre well.

I often wonder where people come across all these WLI users who only ever had a stone to lose in the first place. In fact as someone who’s used them for 18 months I’ve only come across 2 other people in real life who have also use them so goodness knows where people are finding the one stone to lose folks who must be as rare as hens teeth in the first place.

I’m only a couple of months into WLI but I can see the point some are making here - it is very easy to abuse and for those with existing eating disorders there is a huge risk factor in using them. In an ideal world they would be prescribed as part of a holistic diet and exercise programme so people are maintaining their lean muscle mass and then shown how to eat well at maintenance, and their overall health and wellbeing was being monitored. Instead it’s a bit of a Wild West out there.

So I am definitely someone that has taken WLI and got towards the bottom end of the healthy bmi, but still over 20. I wouldn’t want to get to 18.5 or whatever the bottom is, but I am well away from a bmi of 25.

I think there are lots of us that are maintaining (I’ve been around 8st for months and months now) maybe slightly lower than we would have achieved naturally as we know that maintenance is hard and that tapering and even coming off WLI can involve some level of regain. If I maintain at lower than what would be acceptable if I do have a bounce I’ve got more to play with and it will be easier to lose and stay within a window. It’s self preservation. I’m also interested in set point theory; whether that’s true or not and want to stay at this bmi with WLI for at least two years. I’m also not menopausal wnd only just at the start of peri and know that HRT and menopause can cause weight gain so again, I’m trying to pre-empt these things.

Will I still be a size 6-8 in ten years? Possibly not, but I’m hoping I won’t be above a 12 and still at a healthy BMI.

I’d also add, I was on brutal blood pressure meds, max dose of two, the meds are so brutal you keep needing blood tests as they can damage your kidneys, I’m off them totally, my blood pressure now healthy and unmedicated, my sleep apnea has gone, I sleep 8 hours a night. All the inflammation has gone, no more stiff ankles, my stomach is flat, as my cortisol levels are now healthy again.

im a bmi 20, dress size 8, I likely look my age, youd prob guess me early 50s, no idea , but as arrogant as it sounds, I look very good for it, I am mid fifties, before with my puffy face, double chins, big belly, matronly bust, I probably also looked my age, but I certainly didn’t look good.

I think most people look within 5 years of their age. And I’d rather look good for my age than bad for it. Looking good for your age is directly tied to looking healthy, and no one looks healthy under or over weight, and the further you stray from that corridor, the unhealthier you look.

however I did this for health, the appearance is the cherry on top.

If this is the case (in the UK it seems to be more like 1-2 weeks) it's got bob all to do with changes to tissue structure, or rat intestines, or however the pp was adding 2+2 together and coming up with 76, and everything to do with a slowed emptying of the stomach and the risks that poses under anaesthesia. The same reason people are told to be nil my mouth from a certain amount of time before surgery.

Yes so so many health benefits with these meds.

reduced cancers,
curing cardio vascular discease
curing fatty liver disease,
curing some kidney diseases
anti ageing on all organs due to reduction in inflammation
reduction in arthritic symptoms for the same reason.
reduction in dementia
and that’s over and above the base things they do, ie manage blood sugar and insulin production, meaning our bodies don’t lay down extra glucose as fat and making our body fat available to fuel us.

my husband went on them to lose a couple of stone, his belly basically, once he saw the result I was having, and I am staying on for all the health benefits, been maintaining a year now on a low dose, and quite frankly I don’t want to have to spend every day in a daily struggle feeling deprived. as it is shit for your mental health.

he’s now also considering staying on long term as he has high cholesterol which runs in his family and it’s healthy now, but also his family have a history of dementia and cardio vascular problems, heart attacks in the men, so for him it’s less about weight, and more about proactive health protection.

I think this outlines things well.

On the one hand there is a very helpful outcome for people with certain health issues; on the other they are creating a fresh source of unhealthy body image influences not dissimilar to the whole heroic-chic look that that looked unhealthy but, well, thin, and reinforced that as the key goal. Lots of the rhetoric on here echoes that ("who cares if I look haggard: at least I am THIN" type comments), and I think for those of us who have watched people struggle with (and even, tragically, succumb to) eating disorders, that type of talk is hard to let pass.

The truth is that obesity is a danger to health, but not being stick-thin isn't, and, the truth is people are using them to push down into unhealthy weight loss territory. It is that end of the usage that is a problem, and the attendant rhetoric around "just anything to be thin." I do know people who are looking ill and gaunt on them. I am not about to glamorise that aspect.

Perspective and moderation in the way we discuss these things is key.