I think this is a really good question.
I've absolutely achieved blissful, realisation-of-the-oneness-of-the-universe-and-all-of-life states in both acid trips and meditation.
I found it first on acid, but once I found it, it's much easier to get there with meditation these days. And with meditation you can get in and out of that state more easily, and don't have to put aside so much time for the trip and the return to reality.
Mushrooms are pleasant and beauty-of-life-and-the-universe, but not in the same league, IMHO. It feels much more connected to nature and our earthly existence, whereas acid is more a state of oneness with the totality of the whole universe.
Ketamine has some similar aspects for depth of meaning, but a totally different experience, which I experience more as losing the edges between me and the rest of the universe, all of us blurring into one. Much less euphoric though.
Haven't tried Ayahuasca but would like to.
DMT (the active ingredient) only lasts about 7 mins when smoked and without the inhibitory effects of the rest of the Ayahuasca tea blend, so it gives very pretty visuals but not much in the way of esoteric or spiritual insights. And it's disgustingly harsh to smoke.
On the whole, meditation is good for everyday, whereas the drugs are a max couple of times a year kind of thing. But also, there is so much research currently into benefits of psychedelic therapies for many sorts of trauma, end of life issues, to get people out of depression and anxiety by using the neuroplasticity effects, etc, that I expect to see much greater knowledge and less scare mongering about them in future.