How can I make a comfortable income from home

You're not going to earn £50k working part time from home with no experience or qualifications.

Looked at this thread hoping for suggestions that meet OP’s requirements ha!
What I have noticed is 2 family members do have no issue at all getting work but in the accounts field - last time getting offered several roles when changing jobs - so this seems less impacted than general admin by the few jobs around and low pay.
The more basic qualified one gets jobs around £30k FTE though and most are now moving back to more time in the office. The accounts practice manager gets well over £50k but full time, visiting clients and office based with some flexibility to wfh including out of hours when required. Neither have had 15 years out and both have relevant qualifications and experience.
Will caveat these wages are oop norf so maybe different where you are, a bit higher maybe.
Anyway that is a long winded way of suggesting looking at accountancy or accounts tech or similar type training - though it won’t drag in the cash/wfh for a while it is a bit more similar to admin and it is also something you could teach if you moved on from TA.
I am really not sure business admin is so useful any more, or at least not without other skills to support it - I look around for general admin roles to do p/t now I’m old, after stepping out of my previous management roles (still not £50k) and they’re hard to find at all - especially p/t or wfh - and I’ve spent a lot of the last 40 years in varying offices and never had issues previously picking up such work easily when wanting to do so.
Guess you could try the civil service but you’d have to probably go in at senior management or with say tax qualifications to start on such a wage - but there’s potential flexibility and (a decreasing) availability of wfh.
I will keep checking in to ensure I’ve not missed anything I really shouldn’t have overlooked in the job market!

If I were to go down to 5 hours a day, I would make around 50K in my current job, which is WFH. The difference is I work in a specialised profession and have never stopped working (except for maternity leave). To get 50K after a 15 year break and no current skills is a pipe dream.

There's always tiktok.......

I work from home in medical admin. We have no office we are all remote. Have done for over 9 years. Couldn't go back to a regular office these days or even a 1-2 day a week expectation in an office. I like being exclusively from home.

You are going to be highly unlikely to find a job in administration paying 50k a year after taking time off and not working for a while.

Its often actually much harder to achieve flexibility if you gave up work at any point. Good jobs are not often advertised with flexible or part-time hours, but often people can achieve it when theyve been in the job for a few years then request a more flexible pattern when returning from a maternity leave.

I don't know anyone who got their well paid, part-time hours job by applying for it as a pt role.... They all previously held the post as a full time role and requested reduced hours after having children.

God, imagine the HR though.

People need to think outside the box. Cynthia Payne made a fair bit of income, and she didn't even do the work herself.

Surely your best bet is being a teaching assistant. How do you think you can get &50k working from home when your previous experience was business admin?

May be try getting several different income streams for flexibility? One could be exam invigilator, tutoring perhaps, part time in a retail store, do market research.

interested to know why you bothered to train as a TA if that’s your salary expectation?!

Where does anyone who hasn’t worked for 15 years get these ridiculous salary expectations from? Sadly I think it’s because they haven’t worked that they have these daft ideas and sense of entitlement as to what they are worth.

I have a brilliant morning job that works around being a parent to a primary school age child but I earn a third of what you call "comfortable" (and it's not from home).

Well national minimum wage is £26,430 a year… so there are huge numbers of professionals working for a lot more than 13% above NMW. As there should be.

£50,000 doing part-time hours? So that’s like an £80,000 job? That is an enormous salary for admin, even if you’d been working your way up for the last fifteen years instead of taking that time out of work. I think you need to spend some time looking through the jobs pages to see what salaries actually look like, and what eexperience is required.

If you speak a foreign language you can make big money working for a bank.. not sure of wfh options

Social media influencer if you’ve got an angle that people will want to follow you for! It might take time to build up but I have paid influencers a LOT of money for making a 30 second video

OP keep an eye out for school admin/reception roles. Obviously wouldn’t be wfh but you’d have the right hours. Either that or start your own business. I’m in the same situation and I have just started a home help business x

The problem you have is that you either have to get a job with that as the attached salary and WFH as an option

or

You have to start your own business - which is what I do - but new businesses rarely return big profits early on, its not unusual to see a loss for a few years, then a slow creep into profitability. And of course, you need to have an idea that people want and is sustainable over a long period of time.

Prostitution?

So you mean WFH as an employee rather than some business of your own?

I did several years WFH with Citizens Advice on different workstreams.

While some local outfits seem to expect attendance at an office n days a week others do not, Once they've accepted 100% WFH they then twig they can recruit nationally rather than just fishing in a pool of those who can get to the office.

Last I was at was in SE England. There was a sort of coincidental cluster in the East Midlands but one was in the NW of Scotland.

I would recommend looking at qualifying as a parish clerk and working towards a town clerk post. I did this when my children were very little as it’s flexible and home based. Very well experienced clerks can earn £60k +, start small with your admin experience and a council will pay for you to qualify.

I now earn very almost that working for a local authority in my early 30s. I work full time but hours that suit me and do a few hours twice a week in an evening to facilitate pick ups in the week combining my old degree in a property related field with the local government experience. Local government finds it quite difficult to recruit in my experience and is massively flexible.

Selling magic beans in Cloud Cuckoo Land.

That is quite a salary with lower experience levels.

If you need school hours have you considered being a TA or LSA in a school? Or if you are extra brave a Secondary Cover Supervisor or Student Elsa / Attendance Support Officer? Sorry nowhere near £50k in fact you will be lucky for half that, but you will have school hours and term time so you save on holiday clubs etc.

School Reception? School Suport jobs are hard work and incredibly underpaid, but you get the holidays so you have to accept the fate.
Perhaps you could look into childminding at home, not the easiest but some have a few and earn well from it, you could opt for term time only which obvs is less money (some have additional extra holiday club weeks).. This can be financially rewarding but emotionally and physically tough and in your own home.
or use your recent qualifications and work your way up.

Kindly, I think your expectations as someone who has been out of work for 15 years and will effectively be starting from the bottom are out of whack with reality.

The Civil Service tends to have good opportunities for flexible work and progression. You can expect to start off on £25ish for an administration role. Most roles are highly competitive and you would be spending several hours on each application but once you've secured a role you can probably work hybrid and flexible hours.