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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

to feel uneasy about what this means long term rather than surprised by the weight regain itself?

682 replies

HazelMember · 28/01/2026 18:03

I’ve just read a BBC article about research into weight loss injections like Ozempic and Wegovy showing that people who stop taking them tend to regain weight quite quickly.

I’m not shocked that weight comes back. That happens after most weight loss attempts whether they involve medication or not.

These drugs are increasingly talked about as something people might take for years or even indefinitely. That raises questions for me about what happens when someone cannot afford them anymore, when supply changes, when side effects become an issue or when a person simply does not want to stay on a medication for life.

If stopping leads not just to regain but to a fairly rapid rebound, it feels less like a temporary aid and more like something that is very hard to step away from once started. That sits oddly with how casually they are sometimes discussed.

AIBU to think the real issue here is not that people regain weight after stopping, but whether we are quietly normalising a treatment that may be difficult to discontinue once begun? Or is this simply the reality of managing a chronic condition?

A woman, wearing bright red nail polish and unbuttoned blue jeans, injects herself into the skin and soft tissue of her lower abdomen with an obesity jab pen.

People coming off weight-loss injections risk fast weight gain

Overweight people shed large amounts on jabs but gain 0.8 kg a month on average once off them, study shows.

https://www.bbc.co.uk/news/articles/c050ljnrv2qo

OP posts:
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14
Duckishness · 29/01/2026 22:04

HazelMember · 29/01/2026 21:56

When you start talking about “twisted, vengeful little minds” and using phrases like “evil fatties,” you just sound nasty.

Not everyone who questions WLIs is secretly rooting for fat people to suffer or die early. Some people have concerns about long-term effects, side effects, access or the way these drugs get framed as a moral fix rather than a medical one. You don’t have to agree with them but pretending they’re all driven by spite doesn't help anyone.

I get that except evidence suggests there isn’t the same concern for the number of people who started taking statins, for example, or lots of other ‘cash cow pharma’ products (your words) that likely require lifelong treatment and impact the same % of the population. It’s just all those aren’t visible in the same way of shrouded in inherent bias as obesity is.

So why the interest in the long-term
impact of WLI. Rhetorical question as I know the answers.

sprigatito · 29/01/2026 22:02

HazelMember · 29/01/2026 21:56

When you start talking about “twisted, vengeful little minds” and using phrases like “evil fatties,” you just sound nasty.

Not everyone who questions WLIs is secretly rooting for fat people to suffer or die early. Some people have concerns about long-term effects, side effects, access or the way these drugs get framed as a moral fix rather than a medical one. You don’t have to agree with them but pretending they’re all driven by spite doesn't help anyone.

That would be why I didn’t address my comment to “everyone who questions WLI”. The posters who witter on about loose skin and ageing faces however, whether they do so gleefully or dress it up as concern, are arseholes, and there are a lot of them on MN. If you think I “sound nasty” for being blunt about what I think of them, well, I won’t be losing any sleep over it.

Binus · 29/01/2026 21:58

What's a moral fix, do you mean like how fatness is viewed as because people are in some way behaving wrong and then the jabs means they don't get that any more?

HazelMember · 29/01/2026 21:56

sprigatito · 29/01/2026 21:34

That’s exactly why they do it. In their twisted, vengeful little minds, there simply must be a punishment for the gluttony and general moral degeneracy of obesity. If WLI have provided the evil fatties with a way of cheating their way out of early death and public ridicule, then they can only comfort themselves by pointing out that we must have yards of loose skin, muscle depletion and premature ageing. That’s just enough bile to tide them over until we inevitably “put it all back on again” and the real crowing can start.

When you start talking about “twisted, vengeful little minds” and using phrases like “evil fatties,” you just sound nasty.

Not everyone who questions WLIs is secretly rooting for fat people to suffer or die early. Some people have concerns about long-term effects, side effects, access or the way these drugs get framed as a moral fix rather than a medical one. You don’t have to agree with them but pretending they’re all driven by spite doesn't help anyone.

OP posts:
RufustheFactuaIReindeer · 29/01/2026 21:42

soupyspoon · 29/01/2026 21:30

Its absolutely meant that way

Along with an 'aging face'

'oooh she's aged'.

My hairdresser has lost loads of weight, she is almost afraid to eat now cos even when she had one choc out of the selection box she was getting comments from her colleagues

she gets told a lot that its aged her….she looks stunning, people are stupid

sprigatito · 29/01/2026 21:34

SilenceInside · 29/01/2026 20:50

I’ve lost 11 stone. I don’t have loose skin that needs managing, I’ve got a bit of crepeyness on my inner thighs, a bit of a stomach roll but it’s no longer an overhang as it’s shrunk back, I’ve also had two large babies and two c sections so it’s never going to be flat. I’ve got a bit of bingo wings going on but that seems to be improving a lot recently. It’s nothing like what you see on social media, of people who have lost multiple stones and have hanging sagging skin. It’s obviously a possibility but it’s not a reason to remain obese, or to fear losing the weight. Try and lose weight at a steady pace, and try to exercise and eat well, but that’s good advice generally not just to minimise loose skin.

It just sometimes seems like the “threat” of loose skin is used as a way to needle and poke at obese people, to say that even if you do lose the weight you’ll still be “unworthy” and just have swapped one health issue for another that’s just as bad. I’m sure it’s not meant that way but that’s sometimes how it seems.

That’s exactly why they do it. In their twisted, vengeful little minds, there simply must be a punishment for the gluttony and general moral degeneracy of obesity. If WLI have provided the evil fatties with a way of cheating their way out of early death and public ridicule, then they can only comfort themselves by pointing out that we must have yards of loose skin, muscle depletion and premature ageing. That’s just enough bile to tide them over until we inevitably “put it all back on again” and the real crowing can start.

soupyspoon · 29/01/2026 21:30

SilenceInside · 29/01/2026 20:50

I’ve lost 11 stone. I don’t have loose skin that needs managing, I’ve got a bit of crepeyness on my inner thighs, a bit of a stomach roll but it’s no longer an overhang as it’s shrunk back, I’ve also had two large babies and two c sections so it’s never going to be flat. I’ve got a bit of bingo wings going on but that seems to be improving a lot recently. It’s nothing like what you see on social media, of people who have lost multiple stones and have hanging sagging skin. It’s obviously a possibility but it’s not a reason to remain obese, or to fear losing the weight. Try and lose weight at a steady pace, and try to exercise and eat well, but that’s good advice generally not just to minimise loose skin.

It just sometimes seems like the “threat” of loose skin is used as a way to needle and poke at obese people, to say that even if you do lose the weight you’ll still be “unworthy” and just have swapped one health issue for another that’s just as bad. I’m sure it’s not meant that way but that’s sometimes how it seems.

Its absolutely meant that way

Along with an 'aging face'

'oooh she's aged'.

soupyspoon · 29/01/2026 21:29

Managing in what way?

I lost 10 stone and have loads of loose skin, I look like a pelmet and my skin was very stretched and not elastic and Im old so it was inevitable. Im a big wrinkle

It doesnt bother me, I find it fascinating in a way that it used to be all full of fat.

I look great when dressed but I didnt do it for that anyway, I did it for my health.

SilenceInside · 29/01/2026 20:50

I’ve lost 11 stone. I don’t have loose skin that needs managing, I’ve got a bit of crepeyness on my inner thighs, a bit of a stomach roll but it’s no longer an overhang as it’s shrunk back, I’ve also had two large babies and two c sections so it’s never going to be flat. I’ve got a bit of bingo wings going on but that seems to be improving a lot recently. It’s nothing like what you see on social media, of people who have lost multiple stones and have hanging sagging skin. It’s obviously a possibility but it’s not a reason to remain obese, or to fear losing the weight. Try and lose weight at a steady pace, and try to exercise and eat well, but that’s good advice generally not just to minimise loose skin.

It just sometimes seems like the “threat” of loose skin is used as a way to needle and poke at obese people, to say that even if you do lose the weight you’ll still be “unworthy” and just have swapped one health issue for another that’s just as bad. I’m sure it’s not meant that way but that’s sometimes how it seems.

Perimenoanti · 29/01/2026 20:31

SwingTheMonkey · 29/01/2026 20:20

I literally cannot understand the thought process of someone who would remain dangerously, unhealthily overweight, just so they didn’t have loose skin. I’ve got some loose skin on my stomach. I’ve carried 4 babies, all c sections and have been overweight for years so it’s going nowhere. I look good in clothes and ok in undies and my body is healthy so who cares?!

Edited

There are people who have a lot to loose and the loose skin will need managing. It won't be just a bit of loose skin. No point risking the effects of obesity but for some the loose skin issue won't just be purely cosmetic. This in itself can have challenges and I don't understand why anyone would dismiss that.

SwingTheMonkey · 29/01/2026 20:20

soupyspoon · 29/01/2026 20:07

I love the loose skin posts.

Because some loose skin is much much worse than being 20 stone.

I literally cannot understand the thought process of someone who would remain dangerously, unhealthily overweight, just so they didn’t have loose skin. I’ve got some loose skin on my stomach. I’ve carried 4 babies, all c sections and have been overweight for years so it’s going nowhere. I look good in clothes and ok in undies and my body is healthy so who cares?!

soupyspoon · 29/01/2026 20:07

I love the loose skin posts.

Because some loose skin is much much worse than being 20 stone.

RufustheFactuaIReindeer · 29/01/2026 19:08

I think how much exercise can help with weight management would vary greatly between individuals

this

even when i was at the gym for an hour and a half a day 6 days a week in my 20’s i didnt lose an ounce

friend of mine runs so she can eat what she likes, in her case the exercise balances out the food intake…and wine 😀

Whataninterestinglookingpotato · 29/01/2026 18:17

HeidiLite · 29/01/2026 17:38

yes absolutely exercise helps. But only moderately. And ironically, fit people actually utilise fewer calories on other tasks - they become more efficient.
Pontzer et al., Constrained Total Energy Expenditure and Metabolic Adaptation challenges the classic idea that total daily calorie burn increases linearly with physical activity. Instead, after a point, energy expenditure plateaus, meaning the body adapts by reducing energy spent on other physiological processes so total expenditure stays within a narrower range.

Or see Exercise Paradox (Herman Pontzer) - People with extremely high daily activity (e.g., walking many kilometers) don’t necessarily burn more calories overall than sedentary individuals. He studied the hunter-gatherer tribes that are very active the entire day, but didn't actually burn more calories than a random office worker.

I find this topic quite fascinating.

Just to be clear, definitely not saying people shoud not exercise. Quite the opposite and I myself pretty much live at the gym. But an obese person won't become a slim one just by starting C25K, if they don't sort out eating.

Find this fascinating also. I exercise a lot but the calories I burn daily are pretty average and probably not loads more than people who live a much more sedentary lifestyle, unless I run 10+ miles etc. you also don’t burn masses more calories running than walking, but I prefer to run for the other benefits. My weight remains steady and I don’t really loose or gain more than a few pounds.

you definitely can’t outrun a bad diet, you have to adapt your food intake along side. A lot of people actually gain weight while marathon training as you need to fuel your body for the exertion you feel but you don’t always burn as many calories off.

that said, you do burn more calories when you first start and so for someone starting a weight loss journey exercising alongside will likely be beneficial both in terms of burning more calories and just generally feeling better in yourself. But you do need to keep increasing the intensity or you do just plateau as you adapt to the level of activity. You have to learn to enjoy the exercise for the other benefits rather than just doing it for wait loss as the gains aren’t always particularly impressive.

Disturbia81 · 29/01/2026 18:05

sprigatito · 29/01/2026 17:58

I think it’s true that you can’t out-exercise a bad diet, but if you’re already eating close to weight loss amounts of decent whole foods, then exercise actually makes a lot of difference. Even walking burns enough calories to make a noticeable difference for me.

Absolutely this. It makes a huge difference if diet is healthy and body fat is low. I see my muscles grow daily and it’s very satisfying

sprigatito · 29/01/2026 17:58

I think it’s true that you can’t out-exercise a bad diet, but if you’re already eating close to weight loss amounts of decent whole foods, then exercise actually makes a lot of difference. Even walking burns enough calories to make a noticeable difference for me.

MO0N · 29/01/2026 17:55

If I do more cardio my bodyfat melts away and I have trouble eating enough to keep myself over 8 stone. Running especially makes me shed bodyfat.
This has always been the case for me and it remains so at age 60.

Perimenoanti · 29/01/2026 17:42

SwingTheMonkey · 29/01/2026 17:39

Loose skin isn’t going to put you at risk of a heart attack, stroke, diabetes or cancer.

I know that. It can cause some severe psyochological issues in some people. It may very well be limiting. Not all ailments are physical.

SwingTheMonkey · 29/01/2026 17:39

Perimenoanti · 29/01/2026 14:38

@SwingTheMonkey Today I say I won't mind loose skin as the disadvantages of being obese are higher, but I do wonder how I will feel once I actually have loose skin. I do imagine it will be difficult too. I can't say whether it would bother me enough to do something about it or if it's just going to be a niggle. I agree obesity is a ticking time bomb so I hope it won't go off on me and loose skin will seem easier to deal with.

Loose skin isn’t going to put you at risk of a heart attack, stroke, diabetes or cancer.

HeidiLite · 29/01/2026 17:38

yes absolutely exercise helps. But only moderately. And ironically, fit people actually utilise fewer calories on other tasks - they become more efficient.
Pontzer et al., Constrained Total Energy Expenditure and Metabolic Adaptation challenges the classic idea that total daily calorie burn increases linearly with physical activity. Instead, after a point, energy expenditure plateaus, meaning the body adapts by reducing energy spent on other physiological processes so total expenditure stays within a narrower range.

Or see Exercise Paradox (Herman Pontzer) - People with extremely high daily activity (e.g., walking many kilometers) don’t necessarily burn more calories overall than sedentary individuals. He studied the hunter-gatherer tribes that are very active the entire day, but didn't actually burn more calories than a random office worker.

I find this topic quite fascinating.

Just to be clear, definitely not saying people shoud not exercise. Quite the opposite and I myself pretty much live at the gym. But an obese person won't become a slim one just by starting C25K, if they don't sort out eating.

KimberleyClark · 29/01/2026 17:21

HeidiLite · 29/01/2026 16:54

No idea why she’s never just taken up running or the gym long term instead, it would be far more beneficial for her long term health.

While I don't disagree that exercise is great for your health, exercise has surprisingly little effect on weight loss. I've been fat while working as a fitness instructor. I didn't lose a single kilo while intensively training for half marathon.
And of course it is not so pleasant to exercise when she has a BMI in 30s.

In my opinion, WLIs are not comparable to herbalife shakes or some weird restrictive cabbage soup and an egg diets. And believe me, I've done them all as well, I didn't know better. I hope your mum gets some support and nutritional advice alongside, and yes, joins a gym as well - this could be an opportinity for her to significantly improve her life.

One would think that exercise would help keep you in calorie deficit though.

I think how much exercise can help with weight management would vary greatly between individuals.

HeidiLite · 29/01/2026 16:54

No idea why she’s never just taken up running or the gym long term instead, it would be far more beneficial for her long term health.

While I don't disagree that exercise is great for your health, exercise has surprisingly little effect on weight loss. I've been fat while working as a fitness instructor. I didn't lose a single kilo while intensively training for half marathon.
And of course it is not so pleasant to exercise when she has a BMI in 30s.

In my opinion, WLIs are not comparable to herbalife shakes or some weird restrictive cabbage soup and an egg diets. And believe me, I've done them all as well, I didn't know better. I hope your mum gets some support and nutritional advice alongside, and yes, joins a gym as well - this could be an opportinity for her to significantly improve her life.

MsWilmottsGhost · 29/01/2026 16:20

Bloozie · 28/01/2026 22:03

https://pubmed.ncbi.nlm.nih.gov/33899337/

https://www.sciencedirect.com/science/article/pii/S147021182404572X

Reducing such a complex issue down to 'eat less, move more' and 'learn to cook', and the other bullshit on this thread, is pure ignorance.

People on WLI know they are likely to regain weight after. They know this because it's a pattern we've experienced our whole fucking lives. I have lost weight the willpower way, I've lost weight the cabbage diet way, I've lost weight the personal trainer twice a week, swim a mile 3 times a week, run 5k twice a week and keto diet way. I've done intermittent fasting. The weight comes back. I eat exactly the same as my husband and move more. He is not obese. I am.

All the moralising on this thread, like fat people just have no idea how to lose weight is a pure waste of your time.

We know. We know better than you. No one knows more about the calore content of an apple vs a biscuit, a spoon of hummus vs mayo, what adding baked beans on your cheese does to the glycaemic index of your lunchtime jacket potato, than a fat person.

Believe me, we know.

We also, therefore, know that it will be difficult coming off mounjaro or whichever GLP-1 receptor we're on.

But thanks for the concern, guys. It feels SUPER sincere. No, really.

Edited

Those papers say "The causes of obesity are manifold and cannot be attributed to one single cause, such as overeating. In most cases, including polygenic obesity, the factors causing obesity are modifiable". They also say those factors are "physical activity environment, food consumption, food production, individual psychology and social psychology".

People's relationship with food is complex, so saying "eat less, move more" is like saying to an addict "why not just stop". When I was a 1990s smoker it used to make me very cross that the govt message was simultaneously "just stop smoking, it's so bad for you" while also tobacco advertising was absolutely everywhere, and fags sold on every street corner. Eventually I did quit, and it was a whole lot easier when advertising was stopped, non-smoking areas became the norm, and fags were hidden away behind counters.

Junk food is sold everywhere, promoted everywhere, cheaper than healthy food, and physiologically highly addictive, yet people are just supposed to say no using willpower alone, despite being completely surrounded by messaging that says more more more.

It's definitely not just a case of "eat less, move more", and I agree it is unfair to blame the behaviour of individual people for a global public health issue.

MsWilmottsGhost · 29/01/2026 15:45

Yadooo · 28/01/2026 20:02

Good to know. I can't admit in real life that I would be trying to get them to curb my appetite despite only being 9st10 and 5'6. Food noise has been the bane of my life so if I can afford to get them, I will.

This is why they should be prescription only though. At that height and weight you definitely do not need them.

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