to feel uneasy about what this means long term rather than surprised by the weight regain itself?

Here is a quote from David A Kessler, former FDA commissioner, from his book "Diet, Drugs, and Dopamine". He is the former dean of Yale School of Medicine, and other prestigious universities. Kessler has tried GLP-1s himself.

"I am deeply troubled the FDA approved GLP-1s for long-term chronic use without requiring the pharmaceutical companies to conduct enough studies.

The pharmaceutical industry argues that these drugs have been around for decades, but not in such large doses and not for the treatment of obesity.

Some people may be able to handle the drugs for life, but we juct don't know. Right now we only have about five years of data at the current doses."

@velvetgeranium is it just WLI that you’d want that information on or would it apply to any relatively recent medication?

From what is currently known, it is unlikely that babies born to mothers who were taking a GLP1 before knowing they were pregnant would have any issues. Of course there is little data because it is unethical to test it on pregnant women, the same as for any other newly developed medication. Which is why you are clearly told not to take it if pregnant or if trying to become pregnant.

What do you worry would be the implications of long term use of GLP1s, so perhaps a decade or longer, that wouldn’t be an issue for t2 diabetics who would be expected to stay on it, albeit at a lower dose. But that would perhaps just mean it might take a bit longer for issues to appear for them rather than it being definitively safe. Is it cancers, or some other issue?

Botox and fillers.

Well, no. Because as has been pointed out many times on these threads, the dosage is dissimilar and non-diabetics are now using WLI.

Same as happens to the people using the drugs to manage diabetes.

Can you tell me what the long-term implications of being on WLI are?

Or what the long-term implications of being on WLI for several decades are?

Can you tell me what will happen over time to children born to mothers on WLI?

But if you are not using them, wanting to use them, don't have a person you care about who is at risk of buying fakes or using it inappropriately, then why even be interested, let alone "Uneasy"?

Pain killers are the biggest legitimate drug which are misused.

Thread after thread after thread after thre....

Oh, wait, there isnt any threads about painkillers being abused and concern about that

Thats strange.

“Hot tip” - don’t quote me out of context.

Wonder if OP is also concerned about the massive trend of healthy people taking medications "off-label" to slow down aging (cholesterol, Alzheimer’s etc) and seeking prescriptions outside the NHS including for newer drugs that don’t have the length of data on safety profile.

Or is it just WLI.

Maybe because posters are picking up on the word 'concern' as not being genuine.

It's a word with more meanings than you have assumed, as I pointed out.

It doesn't matter how any OP is phrased on these threads, the OP is bashed, as is anyone who tries to join in who has similar considerations they'd like to discuss.

Maybe because posters are picking up on the word 'concern' as not being genuine. Its not the true purpose of the thread. Its contradictory to what obesity does to people. Society isn't known to have concern for obese adults. Society still thinks its a weakness. The concern here is backwards.

So why the interest in the long-term
impact of WLI. Rhetorical question as I know the answers.

It might be a rhetorical question for you. You think you know the answers in why people are interested in the long-term impacts - envious, spiteful, whatever.

But the truth of the matter is no-one knows the long-term impacts of WLI. They don't know the impact of WLI on babies in the womb, born to women on WLI. They don't know the effect on body systems over the course of decades, for people on WLI. Nobody knows!

I think people would be even more “concerned” if the NHS was paying for the vast majority of WLI prescriptions. I’m glad that I’m privately paying for it as the financial decisions are purely my own and impact no one else at all. So the concern seems a bit, I don’t know, patronising or similar given that it’s my money and my decision making process. Of course I realise that I might not be able to pay for them forever if my circumstances radically change, but I am fairly certain that I can if I need to. If I could only afford them for a fixed amount of time, well, that would be for me to cope with and manage. No one else’s concern would help or be useful in any way. It wouldn’t stop me from trying to lose the weight and maintain it, even if it was then going to be harder to maintain the weight loss. I’d rather try than not.

I have read articles about whether taking stations long term is a good thing. And have had more discussions about that with friends than I have about weight loss injections.
Doesn't it make sense to ask about term effects of all.medications?
I don't understand why people are questioning research into the impact of WLI.

Pretty sure all of us paying for them are saving the NHS in the long run.
Extremely obese people with lifelong conditions do get them for free on the NHS.
Why did you start this thread if you’re not taking them or don’t need to OP?

I think the difference is that we have to pay for WLI. Or at least that’s how I read OP’s concern in the first post. That lots of people started them not realising they’d likely have to stay on them forever, and they may not always be in a financial position to do so unlike statins etc which we get for free.

Exactly. It is baffling to me why we - outside of the WLI board, where people can discuss whatever about losing or gaining weight, and the use of WLI, their side-effects, their lack of side-effects, pass on some tips, support and encourage each other, whatever they want - can't discuss real-world 'concerns' about WLI.

Every word is picked over. Someone writes 'concerns' which is a perfectly reasonable word in this context (relating to, about, relevant to, affecting, involving) and someone or many someones fires back: "If you're so concerned, why don't you... 'Why are you more concerned for my health than I am?" "Why aren't you concerned about statins??" etc

Hot tip: Just for starters, statins aren't so in demand they are being counterfeited, home-compounded, or sold on the black market. Statins aren't being sought out by people who really don't need them.

Maybe its just another bias towards fat people. I would be concerned about a child or vulnerable adult. Not about someone obese as if they aren't able to make an informed decision. Anything and everything comes with risks. I could die tomorrow from a stroke, but if I suffered a rare side effect from WLI id probably get told 'told you so'.

When was the last time you had concerns over a medication you, personally, were not using? Me? Never. And yet these people are so worried about the folks using WLI. I guess we should feel very privileged- they’re not worried about anyone else’s medications…

I am seriously puzzled as to why people who don't use WLI and have no intention of using WLI should be concerned, "uneasy", or even give two hoots about what others choose to do?

I don't see it as weight loss bashing at all. It is asking a serious question based on real research.

I don't understand the word concern here. If you are concerned don't take them? Or if you are concerned do something for a good cause related to obesity? Why aren't you showing the same concern for obesity that has effects that kill? Heart disease and stroke are right up there as the top causes of death. Cancers are a bit further down.

What do you want to achieve with concern? Maybe talk to a friend or a therapist about your concern?

Exactly, some people have no idea

Do you really think you are more informed to be concerned about my health more than I do? That I'm not able to weigh up cost, risk and benefit? Why is me taking a medicine in line with the regulations which are based on actual evidence rather than assumptions up for debate? Would you like to debate my daily antihistamine or hrt? What makes this decision compared to those?

But you care so very very much 🤔

Because those challenges won’t be any
where near as bad as navigating life changing disabilities because you’ve had a stroke or facing debilitating treatments because you’ve developed a weight related cancer.