to feel uneasy about what this means long term rather than surprised by the weight regain itself?

I don’t have an opinion it.

That isnt what the science says though

Theres lots of nuance and complexity to it

What about alcoholism?

Self inflicted

More or less, yes. I’m overweight and I know fine well why I am!

Look upthread^

A self-inflicted condition, as I said.

Because?

Because it’s self inflicted in your view? Again what should it be classed as then?

I don’t feel it should be, like I said upthread.

I would have agreed with you post menopause and now I have put on 1 stone 5 pounds on in the space of 7 months. Admittedly some of that was going to lots of celebrations over the past few months.
Insulin resistance is a thing and it’s so hard to reverse. Of course it can be done but it’s so difficult. What worked 11 months ago doesn’t work anymore. Or it takes longer. I am in favour of these drugs, it gets people out of insulin resistance and stops food noise.

Except people with medical qualifications and expertise say otherwise.

Its classed as a disease.

@ladyamy is that opinion about obesity as a condition based on anything, as it’s at odds to the medical bodies that look into these things. They do classify obesity as a disease or condition in a medical sense. You believe it’s not something medical because you think it’s a simple choice and that anyone who is obese could easily become not obese if they chose not to be.

What should it be classed as then?

I didn’t say anyone is any more or less deserving of anything. I don’t feel obesity should be classed as a ‘condition’ in the medical sense, that’s all. Have a nice evening.

I do wish to be on them for life, and have had no side effects.

My primary reason to stay on are the health benefits in terms of cardio vascular, kidney, liver health, reduced inflammation, the anti ageing effect this gives on our organs, reduced cancers and now other elements being tested ie reduced dementia. So so many health benefits.

the icing on the cake is being able to stay slim, not struggling, not feeling deprived, maintaining my weight with ease, and liking my appearance again and the mental health benefits all that brings. So for Me, it’s a yes please.

What point are you trying to make, your post comes across that you feel obese people are less deserving than uou as in your opinion they became obese for eating too much and not moving enough. I’m sure you don’t mean this, so maybe explain more?

They're not.

I have them prescribed by my GP, so there's no charge. But they are not for weight loss. They are to manage a medical condition (diabetes).

@Matronic6 would you have been eligible for a prescription at BMI 29? Presumably you have a weight related health condition that would have qualified you, or you qualify on ethnicity grounds where the boundary for an obese BMI starts at 27.

I was overweight with a bmi of 29 last March. I did consider WLI's and could afford them. But I decided against die to my concern of side effects and definitely being able to come off them. I personally don't want to be on any medication for life.

I did lose weight and am now at a bmi of just over 25 as I felt like changing habits and routines was the healthier thing for me in the long term.

But the concern about rapid weight gain when coming off it was real as was being dependent on a drug for the rest of my life. And it clearly is a real concern as it is being as the issue is already being addressed by the medical community itself. So there clearly is more to it than people not being able to stand 'fatties being thin.'

Most people on lifelong medication, like me, have diagnosed illnesses (Multiple Sclerosis, in my case) and do not have a ‘condition’ that is self-inflicted (by eating too much and moving too little).

Dont get me wrong, I’m around a stone and a half overweight myself so please don’t take this as ‘fat-bashing’ but it hits a nerve for me when I hear someone refer to obesity as a ‘condition’ when their choices led to their ‘condition’ and there was nothing I could have done to prevent mine.

I wish everyone on WLI all the very best, I’ve heard some great success stories! 😊

There were 37 trials included in the meta analysis. Of the handful that were about tirzepatide (Mounjaro), the participants either stopped at the end of the trial or were switched onto a placebo. During the trials they were encouraged to stick to a 500 cal daily deficit and aim for 150 mins of exercise a week, but there is no analysis of whether they actually did any of that, either during the trials or afterwards.

I was going to ask about the reduction, so at the end of the trial they just stopped?

Also in any of the early trials participants would have had to follow 'the trial protocol'. They would have been increasing the dose every 4 weeks from 2.5mg, to 5mg, to 7.5mg, etc up to 15mg. I would never have made it. struggled to get beyond 6mg without suffereing from nausea. However, on something between 2 and 4 mg I have lost 20kg and I have been maintaining a healthy BMI since July.

I would have been kicked out of the trials because I couldn't adhere to the schedule. I'd also not have been able to take anything other than the 'standard prescribed dose' i.e. 2.5mg or 5mg - no half doses or adjustments by counting clicks. tbh I've had the same with a prescription medicine for blood pressure where I can't take the full dose without feeling lightheaded (probably a drop in BP) but a half dose - which keeps my BP perfectly stable - is 'clinically ineffective' according to my GP. Well, actually not for my body!

Also, I think in some of the early trials the WLI just stopped. There was no titrating down, there was no long term management. There was no supportive communiity.

Having spent a lot on money on WLI I am incredibly motivated to keep on maintaining a healthy weight. I don't want to pay that all over again.

Yes, absolutely, and people are on average losing much much more than 8kg, I don’t think many go on to lose that little. For me the key data is real life usage, and the studies done on that are very different.

i mean who cares really if people on the trial lost a small amount of weight then gained it back after.