If you are on weight loss injections, what do you make of this article?

@Dragonscaledaisy apologies it seems that Nevolat is available, which is liraglutide as you say. There is no generic semaglutide or Tirzepatide at the moment though.

I lost 1 stone in 9 months. Put 1.5 stone back on in 6.
I am now doing 800 fast, no booze, no carbs.

I also have a damaged sigmoid colon from the jabs - regular a&e trips and will be on and off antibiotics for life.

I think ‘duh’ that’s also the case for obese people who lose the weight through diet. There’s no magic bullet, people are predisposed to obesity and have to work really hard to stand firm against that predisposition

Thanks for your insight 🙄

Nevolate plus others I think - all generics of liraglutide as that's off patent now.

Firstly, the paper is not a gospel or oracle of truth. The papers is is based on extrapolations from evidence of other studies. It is not the presentation of dogmatic facts but more of a discussion paper.

Researchers behind the paper, published in the BMJ late on Wednesday, analysed data from more than 9,000 people from 37 studies that examined the effects of ceasing the drugs. On average, the participants took the medicines for 39 weeks and provided follow-up data for 32. The scientists extrapolated from the studies to forecast what would have happened after a further lapse of time.

The scientists acknowledged limitations in their work including that almost a third of the trials they surveyed had a high risk of bias. The populations in the drug and behavioural treatment programmes might have differed in potentially important ways, such as the degree of obesity and incidence of comorbidities, they added.

All diets tend to work, as long as people are on them and this includes when using WLI. Most people can successfully diet, the problems occur when they stop. Therefore it doesn't take a genius to surmmise that the same will be true for those on WLI. Much more recognition needs to be given to what the co-author of the paper said:

“Obesity is a chronic relapsing condition and it’s very clear that . . . some sort of intervention needs to continue if we’re going to sustain the benefits of these treatments.”

I hope that these articles, instead of encouraging all the ranting frothers to bang on about how fatties are lazy, greedy and bound to fail will actually stimulate more understanding of the problem of the epidemic of obesity we are facing and its multi-causal factors and how best we can deploy WLI and medications to tackle the issues - along with all the other things we should be doing too.

I know people who lost weight (not on WLIs) who are in both camps.

Some are the same or fatter than they were before weight loss. Some have kept it off for near a decade.
The thing the ones who kept it off all have in common were they made permanent lifestyle changes. The ones who regained did not.

@Dragonscaledaisy there aren’t any GLP1 generics available in the UK for weight loss? Can you explain what you’re referring to?

Really? I had no idea!

GLP 1RA generics are already available in the UK - fantastic news for people who can't afford them currently.

I do have some sympathy for the review authors here. It appears they were clear about the limitations of their findings, applied caveats and drew nuanced conclusions. But this being WLI there are going to be lots of people who want the more sensationalised approach instead. It must be frustrating.

I agree - also, WLIs are indicated as an adjunct to lifestyle changes so if people aren't using them correctly in the first place, it's obvious they'll gain weight when they stop using them. Weight regain was low in longer-term clinical trials where patients were using them correctly and were closely monitored.

Nothing.

That’s not a WLI issue it’s a weight loss issue. No matter what the method most people who lose weight regain it in 2 years (some 90% I read).

https://health.clevelandclinic.org/why-people-diet-lose-weight-and-gain-it-all-back

Somebody described weight loss as like climbing Everest. Everybody talks about getting to the peak (goal weight) but getting down (maintenance) is just as difficult. If not more so.

This is more trying to scare people away from WLI.

Edit: from the above link:

But before you beat yourself up, endocrinologist and obesity specialist Marcio Griebeler, MD, has some welcome news: It’s most likely not your fault.
“Your body is fighting to keep your weight as it was before the dieting,” he says. But take heart — it’s possible to win the battle.
What “weight set point” has to do with it
Experts think as many as 80 to 95% of dieters gain back the weight they’ve worked so hard to lose. Why? (WHY?!?)
Dr. Griebeler says the culprit is your “weight set point”: the weight your body is programmed to be. Your weight set point is a combination of several factors, including your:

• Genetics.
• Hormones.
• Behavior.
• Environment.

It's a thing that could happen, yes. But I think even in the best case scenario not for a while.

Suspect it would probably take cheaper generics being widely available, plus there are logistics. It may well save the NHS money in the long term, but it isn't simple to take resources freed up in eg cholesterol and blood pressure treatment and turn them into WLI expertise instead. So there'd have to be a whole process.

You’ll gain weight back after any diet if you don’t make permanent lifestyle changes. I lost 4.5 stone through diet and exercise and have kept it off for 5 years, but I’m quite sure I could put it back on very easily if I went back to my old habits. I maintain by being consistent which does take significant effort for me. If I let it slip for even a few weeks I do see the weight starting to creep back on.

It’s not surprising to me that the same can happen following stopping WLI’s.

Is it a possibility that in the future we’ll see it prescribed far more widely on the NHS, probably in tablet form, and lots of people will just be on a maintenance dose lifelong?

I’m a long term goal member at SW. we’ve got a lot of people like me who hit goal more than two years ago after losing a lot of weight. The ones who stay at goal still go to meetings and weigh ins every week without fail. I eat no sweets, cake, bread and don’t drink alcohol. I find it challenging having a meal out because a main course at a pub for instance is often over 1000 calories and to maintain weight I know I can’t have more than 1600 calories a day on average, so it limits the occasions I can eat out in a lot of places.

however. It’s worth it for me, and the others in my group because of the changes to our lives that losing the weight has brought to us.

Saying her opinion is stupid and ignorant is attacking her. There's no need to resort to rudeness to make a point.

If you really want non-users to listen to what you're saying and change their opinion on WLI, maybe think on that.

Sigh…

This happened to my friend, she lost the weight then came off it. Put all the weight back on and is back on it again! She said it’s a hunger suppressant, without it she wants to eat more.

No but in what way is it dangerous without monitoring? What are the dangers (widespread dangers please, not very rare outliers) and how do you think monitoring would impact weight gain statistics after stopping?

Well....it took me 20ish years to get 7 stone overweight, with constant fluctuations, always ending up.

If I gain that weight back in the next two years? Ok. Not ideal, and I think unlikely due to the amount and timespan (meaning I could see gaining back 2 stone in 2 years, not 5) but at least I know I can do it again.

I'm hoping I can maintain. But if I can't - well, that's my lookout really isn't it? Is spending £1200 over the course of a year to lose weight any worse than the all the clothing I've bought that I never wore because I bought it to slim into? Is it any worse than the money I wasted buying fast food and snacks? Is it any different than the money I spent on Slimming World over the course of a year, only to gain back every single pound and a LOT more over the years? Probably not.

It's my body, my money.

Like a pp has said lots of people regain weight whatever method they use. And a lot of people find it very hard to stop smoking and drinking but it doesn’t mean they shouldn’t try. You wouldn’t say to an alcoholic “don’t bother trying to stop drinking it won’t work”

I lost 3 stone on MJ last year / the year before but came off it due to cost. I’ve put 1 stone back on. Ideally I’d like to lose that stone and then 1 more.

I don’t regret going on the jabs at all. I’m confident I won’t regain the 2 stone back any time soon and I still feel much better for it.

Viewing this as a horrible situation is so bizarre and divorced from reality. I have a medical condition that negatively affects my body. I'm on medication that entirely treats that. It's amazing. I don't mind paying for it and I can fortunately afford it. Nothing horrible about any of it.

You are. I said her post was stupid and ignorant and it is. I could argue that that poster is attacking people who take WLI’s by insisting people on them are gong to “balloon to double the size” when they inevitably have to stop. It is just utter crap, it’s tedious and people are sick of it.

Stop posting opinions as fact people!