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AIBU?

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Is it the begining of the end for Weight loss injections?

489 replies

BeginingoftheendforWLI · 02/01/2026 18:54

Just watched a report on BBC news, they did an item on a woman who had type 2 diabetes and was prescribed Mounjaro, doctors were impressed she managed to come off insulin within a month. She had some weightloss and now goes to the gym regularly.

Her doctor admitted that there was widespread concern in the medical field that people who were buying it privately for cosmetic reasons not for medical reasons could face some consequences in the future such as muscle growth and bone degeneration and lack of nutrition - they simply don't have this data at present.

Feel like this is going to be big news in the foreseeable future.

OP posts:
Buffypaws · 03/01/2026 09:45

People are defensive because it’s tedious when people say stuff that is irrelevant (some people might get it illegally/abuse it)
or just plain wrong (the drug is designed to make you lose weight faster than any other method, we only have five years’ data on these types of drug)

there is no obvious reason I can see that twenty years after taking this drug, as an active person who skips and eats lots of meat, I will suddenly experience complete muscle wastage. the drug seems to be very safe, there don’t seem to be thalidomide levels of toxicity (and women have even fallen pregnant on these drugs and delivered healthy babies).

Bring something like, MJ causes your foot to fall off in 10% of cases, and I will be interested.

In the meantime I have benefits which are priceless and immeasurable. It’s the difference between enjoying life and suffering through it.

Buffypaws · 03/01/2026 09:40

I can also say that I have fewer side effects from MJ than I did from anti-depressants or in fact codeine

LilyBunch25 · 03/01/2026 09:22

Buffypaws · 03/01/2026 00:51

Mounjaro stops me drinking as much. Terrible!

Yes that was a bonus side effect for me too! I've just transitioned to Wegovy (cost) and want a drink even less...!

LilyBunch25 · 03/01/2026 09:21

BeginingoftheendforWLI · 02/01/2026 18:54

Just watched a report on BBC news, they did an item on a woman who had type 2 diabetes and was prescribed Mounjaro, doctors were impressed she managed to come off insulin within a month. She had some weightloss and now goes to the gym regularly.

Her doctor admitted that there was widespread concern in the medical field that people who were buying it privately for cosmetic reasons not for medical reasons could face some consequences in the future such as muscle growth and bone degeneration and lack of nutrition - they simply don't have this data at present.

Feel like this is going to be big news in the foreseeable future.

OK..............🤔🙄

MissDoubleU · 03/01/2026 09:16

Weight loss surgery consistently results in malnutrition issues. Malabsorption and generally not eating enough has people needing to live their entire life on supplements just to survive.

You know what society cares more about? Them being skinny.

There is no way WLI are going to stop when there are still much, much more extreme options with more lifelong consequences happily being performed nationwide every year.

Arraminta · 03/01/2026 08:58

The Sun? Seriously? I immediately discard the opinion of anyone who reads The Sun and cites it as a reliable research source.

Binus · 03/01/2026 08:56

I'm not sure people raising concerns have realised how much more seriously they'd be taken if they would proactively explain their stance to other MHRA regulated drugs with similar amounts of historical data. And also spend equivalent time airing worries about the risks of obesity itself.

HeidiLite · 03/01/2026 08:34

yes unfortunately there are plenty of people who will buy god knows what from a TikTok link - saw one influencer, also clearly not obese, injecting herself with some weird pink liquid (GLPs are clear) and then livestreaming from hospital as she got a massive allergic reaction.
This has nothing to do with safety of actual medication.

RhaenysRocks · 03/01/2026 08:30

@LydiaFunnyGums why the 🙄? The Sun, or frankly, most newspaper articles are not a good source of information about most things. As @DarkForces said, that article is about fake jabs not the real ones being issued through licenced pharmacies..it's a different conversation completely.

DarkForces · 03/01/2026 08:05

LydiaFunnyGums · 03/01/2026 08:03

Link is ok. Article is called WEIGHT A MINUTE Warning over ‘sophisticated’ fake fat jabs that ‘look like the real thing’ – as demand expected to DOUBLE in 2026
More than 3million people could be on the jabs in 2026.
It highlights the risk of buying it on black market. And also highlights the expense of getting it privately.
I saw the news programme that the OP mentioned. The doctor commented that some people do take it to get the ‘body beautiful’.
If a patient is getting the prescription legitimately through a doctor and has been given all the information to make an informed decision then it’s their choice, their body, their business. It is worrying if people are resorting to getting it on black market though.

But what's it got to do with the actual thread which is about legitimate use?

LydiaFunnyGums · 03/01/2026 08:04

RhaenysRocks · 03/01/2026 07:59

@DarkForces well quite. A link to a tabloid article as evidence and people wonder why WLI users get defensive about being criticised as too stupid or lazy to not use them.

🙄

LydiaFunnyGums · 03/01/2026 08:03

RhaenysRocks · 03/01/2026 07:50

@LydiaFunnyGums can you summarise? Most people aren't going to click on a random tabloid link.

Link is ok. Article is called WEIGHT A MINUTE Warning over ‘sophisticated’ fake fat jabs that ‘look like the real thing’ – as demand expected to DOUBLE in 2026
More than 3million people could be on the jabs in 2026.
It highlights the risk of buying it on black market. And also highlights the expense of getting it privately.
I saw the news programme that the OP mentioned. The doctor commented that some people do take it to get the ‘body beautiful’.
If a patient is getting the prescription legitimately through a doctor and has been given all the information to make an informed decision then it’s their choice, their body, their business. It is worrying if people are resorting to getting it on black market though.

RhaenysRocks · 03/01/2026 07:59

@DarkForces well quite. A link to a tabloid article as evidence and people wonder why WLI users get defensive about being criticised as too stupid or lazy to not use them.

DarkForces · 03/01/2026 07:56

So now we're reduced to having links to the sun about fake products as evidence of the stupidity of people who buy weight loss injections. There's this organisation called gphc who pharmacies register with and it would cost them their licence to sell fake shit. They buy it directly from the manufacturers. You can search the register or go to the main Mounjaro or wegovy price check site where they only link to registered suppliers. It's very easy to avoid fakes and no reason to stop people using the actual drug. Selling fake medicines is a criminal matter for the police.

RhaenysRocks · 03/01/2026 07:50

@LydiaFunnyGums can you summarise? Most people aren't going to click on a random tabloid link.

RhaenysRocks · 03/01/2026 07:46

BunfightBetty · 03/01/2026 01:02

We won't know if they were wrong about that for some time, will we! We'll just have to see what happens over time.

They approved it for those with a high BMI, but people of lower BMIs are taking them, without having the risk profile of those with a higher BMI. That's the biggest concern.

I have no skin in this game, I don't take them and don't plan to. I do worry that some people who don't need them may be taking them without thinking carefully about the downsides.

But that's a different discussion isn't it...people do stuff that's bad for them and not advised all the time. It's got nothing to do with the safety or efficacy of these drugs when used appropriately. People keep talking about rapid weight loss and if some people have many many stones to lose, it does tend to start coming off very fast but many also are losing slowly, less than 1lb a week and gently moving toward a healthy BMI without triggering some of the conditions raised. The issue of people misusing them should be separated from the discussion of their overall safety.

AgnesMcDoo · 03/01/2026 05:11

Cosmetic reasons? @BeginingoftheendforWLI

you mean like losing weight, going from
obese to a healthy weight, decreased risk of diabetes, high blood pressure, heart disease, improved physical fitness, improved mental health and wellbeing?

no I don’t think it’s the end of WLI

DarkForces · 03/01/2026 04:57

BunfightBetty · 03/01/2026 01:02

We won't know if they were wrong about that for some time, will we! We'll just have to see what happens over time.

They approved it for those with a high BMI, but people of lower BMIs are taking them, without having the risk profile of those with a higher BMI. That's the biggest concern.

I have no skin in this game, I don't take them and don't plan to. I do worry that some people who don't need them may be taking them without thinking carefully about the downsides.

I worry about taking them about as much as I worry about taking any other drug I take in the way that it's approved to be by the medicine's regulator and overseen by an expert medical professional. I'm unsure why people are so very concerned about me all of a sudden. They seemed to worry far less about all the additional risks I carried when I was obese and the cost of those to the nhs than they do now I'm a healthy weight thanks to an approved drug that I'm funding myself.

3flyingducksarrive · 03/01/2026 04:27

CharlotteStreetW1 · 02/01/2026 19:22

Already here. I've just been prescribed with the tablets for Type II Diabetes.

(Feeling very ambivalent about it.)

Rybelsus? That is not a new drug and is less effective than the injections. What the pp is talking about is the WLI being delivered as a pill and being as effective as the injections.

SpidersAreShitheads · 03/01/2026 03:21

ThoseWeirdStones · 03/01/2026 00:40

I think this topic generates intense agitation and defensiveness.

I don't have a horse in this particular race, but I hope that it all works out well and people benefit from it.

But I do think there's a rather aggressive push against any measured, cautionary discussion. It seems to cause havoc if criticised or if someone has a negative experience after taking the jabs.
It might be wiser to have a more balanced, nuanced take on such things. We can explore all angles without having to fight.

An emotive subject though. A guaranteed MN page turner for sure:)

I think you’re exactly right.

I understand why; there are many people who have struggled with their weight for a very long time and have now found a solution. Considering any negative data means they might have to think about whether they should stop taking WLI so it’s preferable to take quite an aggressive stance.

People on both sides of the debate cherry-pick stats and anecdotes to suit their stance. Hardly anyone is having a genuinely open and honest conversation; there’s nearly always an agenda, one way or another.

I would love to use WLI but I have one of those annoying bodies that always reacts badly to drugs. I got a blood clot from a COVID vaccine. I’m in that tiny % of people that typically has a bad reaction to many different types of medication.

I’m 50 now so I think it’s probably going to be too late for me. I’d want to see at least 10 years of high-quality, high-quantity data in non-diabetics at a range of different weights, with a variety of other co-morbidities factored in.

I regularly have a little think about trying WLI but don’t think I’ll take the plunge as I’m afraid of the side effects. There have been deaths linked to the use of WLI and I’m just scared I’ll be one of those rare cases.

I’m not opposed to them at all but I don’t think the companies that prescribe them always act ethically and I think there should be tighter regulation. Handing out financial incentives to get others to sign up feels very wrong - these are powerful drugs, not a skincare treatment!

I think we can all hope that the WLI continue to revolutionise healthcare and that in time, there is the data available to reassure scaredy-cats like me that they’re safe to use.

uggmum · 03/01/2026 02:59

GLP1 is an amazing tool for a weight loss journey. I have lost 5 stone. overhauled my diet and exercise.
my blood pressure is normal for the first time in years.
I am a normal bmi after being extremely obese.
I have had loose skin removal surgery and my stomach is completely flat.

it has changed my life and I will be forever grateful.

Dancingspleen1 · 03/01/2026 02:33

devildeepbluesea · 02/01/2026 19:24

I have a good friend who is a senior medic, working in endocrinology- no idea how related this field is but I’m guessing at least a bit.

He maintains that WLIs are great for those who are morbidly obese and the danger of whose co-morbidities outweigh the unknown of WLIs.

However for people who only have a couple of stone to lose it could be cumulatively detrimental. The loss of muscle tone, bone density and who knows what else because we just don’t know yet, outweigh the health benefits of weighing less.

Personally I’d love to be 3 stone lighter but I’m aware that WLIs are likely to take away my appetite and consequently my ability to exercise regularly oreffectively. And that’s the reason I won’t bother. At 52 health is more important than appearance to me.

Well if you are 3 stone overweight then that will adversely effect your health - It's not about appearance in that case. People taking WLI correctly are doing something proactive for their health. Good for them.

Garroty · 03/01/2026 02:20

Nannyogganny · 02/01/2026 19:56

'Obese' is not that big for some people.

Im a size 14 - 16. Im short 5 foot 3.

If I use a BMI calculator, It calculates me as obese. Therefore, I was able to get Mounjaro

Obese is a medical term. It isn't about what you look like or your dress size, it's about the impact your weight is having on your health.

Silvers11 · 03/01/2026 01:47

Nannyogganny · 02/01/2026 20:11

I didn't say I was thin. I said I don't think I am obese.

Obese is the highest weight range possible

A size 14 is not obese. Should I be in the same category as someone who is 28 stone?

Just for the record, severely/morbidly obese is the highest. Below obese is overweight then normal. 😉