Is it the begining of the end for Weight loss injections?

Sounds grim! Personally my previously high blood pressure is lower, which is very debilitating.

Exactly what @SilenceInside said. I honestly think the critics think they must be so much smarter than anyone using MJ that they know something we don't, or are mindlessly injecting any random substance with no thought or research, or that we're all suffering horrific side effects bit dont care. The vast vast majority on my particular support thread have very few or no side effects. In 8 months I had one day of sulpher burps.

So, you've started there with a list of possible side effects that are listed in the Mounjaro patient information. Some of those are very minor, the others unpleasant but not what I would call "nasty". And they are all treatable and manageable, and usually short lived. And not experienced by the majority.

As already discussed, the risk of muscle and bone mass depletion is a potential issue for any diet and is easily countered by exercise and good nutrition. Which is advised when being prescribed. Mounjaro does not cause anorexia, which is a complex mental health issue.

It also doesn't "play havoc" with your liver and pancreas. It has an intended effect on how you process glucagon and on your blood sugar. That's not "playing havoc", what happens is well known and understood and is the intended effect. It is not a "nasty effect" nor does it cause harm.

I have no idea why you think people with T2 diabetes might get '"orange oil" poo and fecal incontinence.' That sounds like someone who cannot digest fat, and is one of the side effects of Orlistat not Mounjaro, and isn't dependent on being T2 diabetic.

Your friend sounds like they are on too high a dose of Mounjaro/Wegovy if they are continually having all those side effects you list, @pollymere

I've a friend who can't eat carbs. Usually it's gut upset such as bad gas, diarrhoea, constipation, sulphur burps, gut cramps and nausea. It can also cause palpitations. Long term it causes depletion of muscle and bone mass. It can also cause anorexia as It dulls the desire to eat but also people enjoy the weight loss so become obsessed which also means they don't want to eat. It can also cause light-headness and dizziness and play havoc with your liver and pancreas in how it processes glucose/glucagon and with insulin production. It sounds like you've been okay though! For people with Type 2, the usual obvious effect is "orange oil" poo and fecal incontinence.

I hope this is what you were asking...

And again, if you actually bothered to read the posts of people on it, they virtually all do / have made lifestyle changes which they intend to be permanent. All these posts about "I know Sheila who got it off the hairdresser for £20 and eats kebabs every day but is skeletal and grey" I think are largely supposition, guesswork and fantasy / tabloid bollocks.

Yeah the effects are so nasty that Mounjaro has cleared up my very severe case of Sebborheic Dermatitis, got my cholesterol under control for the first time in over 20 years and resolved the plantar fasciitis that I suffered with for three years. Really nasty side effects!

@pollymere you say "GLP-1 also has nasty effects on the rest of you" could you expand on what those "nasty effects" are, thanks. Been taking Mounjaro for 18 months and not noticed any nasty effects so it would be really useful to know what to watch out for!

It's great for people who've gained weight through steroid use but those who've gained weight through poor diet without a lifestyle change are going to find it a temporary measure.

Why 'will' when long term maintenance dosing is very much a thing?

GLP-1 also has nasty effects on the rest of you. Not just fat. It's interesting that for many it's the side affect of anorexia that is making them lose weight — they just have no desire to eat. This means that either they will continue to take the drug to dangerously low weight levels or gain weight when they start eating again. It's great for people who've gained weight through steroid use but those who've gained weight through poor diet without a lifestyle change are going to find it a temporary measure. There are people who've had gastric bypasses or stomach stapling who've regained the weight because they didn't change their lifestyle.

I’ve been on anti-depressants for 34 years after a major post natal episode.

I would never offer my opinion on someone else’s healthcare choices.

Why are people so judgemental?

No problem. I am the parent of a type 1 diabetic - terrible condition to have to live with. The key is understanding type 1 is never preventable and there are, technically, no restrictions on foods that can be eaten. Reality is many are careful with sugar and carbs but can eat a 12 inch pizza followed by a cake as big as your head if they want! Just need to get the insulin right - no mean feat, believe me.

Type 2 can be prevented in many cases but age is a factor and genetics can play a part. It is wrong to pull the lifestyle card for all type 2s but type 2s generally need to make an effort to reduce carb intake and make sure they exercise.

Regardless of type, kidney, liver, eye, heart problems are all a possibility and care needs to be taken to avoid problems. Type 2 is not a lesser problem but it is less immediate in terms of seriousness most of the time. Type 1 is the kind of condition where it feels like you cheat death on a regular basis! Type 1 is not particularly well understood by GPs or practise nurses and within the type 1 community, you will hear horror stories related to poor care, including the removal of insulin from prescriptions. I am aware of multiple cases where adults who are diagnosed with type 1 were initially diagnosed with type 2 leading to life threatening situations and terrible trauma for all concerned. If you are ever diagnosed with type 2, keep your wits about you is all I can say.

You absolutely do get people saying that sort of thing about antidepressants! "Happy pills being handed out like sweets" and so on. I agree with your wider point entirely but depression is definitely also an area where people want those affected to suffer their way out of it rather than taking medication.

I'd argue the deep seated, frequently espoused belief that obese humans can simply hard work and good choice their way out of obesity is an example of said behaviour.

Because what we actually know is that human bodies don't work that way, and that obese people are overwhelmingly unlikely to lose weight and keep it off through diet and exercise. However, it takes some work to unlearn this- you have to be willing to actually do the research, question deep seated beliefs and admit that what we thought we knew, we actually don't. To give up on the 'easy solution'. Naturally, some people can't or won't do that.

Ha! Cross posted @Hereagain2

Thank you for explaining this, I know people with both and didn’t know how they were different, apart from 2 being exacerbated by lifestyle.

@Sartre ..you're absolutely right. Let's get rid of anaesthesia and penicillin. They make things far too easy. And gas and air and epidurals for childbirth. And whole we're at it, X rays and MRIs and burn ointment and sterile plasters. If people don't suffer, how will we know they deserve any benefits 🙄🙄

So we should all take our clothes down to the river and bash them on rocks instead of using a washing machine?

Why would you make things harder than they need to be ?

Childbirth without drugs?
Period underwear?
HRT?
Electric kettles?
Cars?
WLI ?

Ridiculous statement.

Fed up of all the MJ bashing,

I don’t know why this medication triggers such resentment. You don’t get people bleating on about anti-depressants or beta-blockers….

Nope, I think along with AI it’s just another sign of things to come. Humans like the easy solution generally, they don’t like to have to work hard for things.

Mmm, the story isn't straight...

And yet in your much quoted previous post, you said you had no idea if his specialist field was related, but you assumed at least a bit. I think you've contradicted yourself somewhat! If he is indeed on the committee, then his field would very clearly be related, no guessing required. My 'guess' is he is not actually on the committee at all, or you would know for sure how his role relates to the subject.

I thought type 2 diabetes was always controlled with tablets and type 1 with insulin injections?

Type 1 is an autoimmune condition whereby the beta cells attack insulin production. Without insulin, Type 1s would die. Many are now using pump therapy rather than injections but the key is getting insulin in.

Type 2 is the pancreas not producing sufficient insulin (often called insulin resistance) which can be caused by lifestyle, age, or for many it runs in families. This can be controlled by improvements to diet and exercise, tablet form medication (usually metformin), or injections like mounjaro. Ultimately, a type 2 may need to inject insulin if other medications don’t work so well.

Rude

Also, if you treat your depression without resorting to drugs (try just feeling happier, getting some gentle exercise or socialising with friends or family), you’re more likely to remain depression free…

yes that's funny isn't it, you don't see people going on depression threads and telling people how worried they are about side effects. Surely you can't stay on those drugs for ever, and your problems will just come back. I know someone who took SSRIs and got sick again when she stopped!
Anyway, have you just tried being happier? I can be happy without medication so it must be possible.

I honestly despair that there are people who would actively set up a new account with appropriate user name, to come on and start a thread asking if it’s the beginning of the end for WLI with nothing whatsoever to back up the question.
Has a brand new, serious, side effect been identified that might prompt this question? No. Just the sheer desire from this poster that people might no longer be able to access a medication that has changed their lives.
What do you have to have wrong with you to do this? What’s your motivation? Perhaps some therapy might be in order?
In addition, why are people happy to be so confidently incorrect in their statements about WLI?
I don’t know anything about oral contraceptives or antidepressants. So I wouldn’t go on a thread about them spouting bollocks, just for the sake of it.