Is it the begining of the end for Weight loss injections?

Also your ‘for life’ would probably have been significantly shorter if you hadn’t lost the weight.

I too am baffled about all this faux concern. WLI are pretty safe (much safer for you than being morbidly obese). We in the medical profession class them as miracle drugs really. Yes, at the moment we don’t know the answer as to the benefit or negatives from long term use. But that’s about it really. No point worrying about 40 years down the line when some people would have been dead within 10 years without them.

At 60, 5’6 and 17stone I was on :
blood pressure meds - FOR LIFE
statins - FOR LIFE
metformin - FOR LIFE
Thyroxine - FOR LIFE

I had lost and regained 3 to 5 stone over a decade since being on steroids for an autoimmune condition. (Which was eventually cured with surgery) however the steroids had made me insanely hungry and my portion control was non existent.

I had been on the ‘eat less move more’ diet. The Atkins Diet, Keto Diet, 8/16 Fasting diet. Cambridge diet. All were successful to a degree but all had the same thing in common. Completely unsustainable.

Read the study produced by Kings College Hospital in 2016. A study of 50k people with simple obesity (BMI 30+) and morbid obesity (BMI 35+) showed that women with simple obesity had a 1:124 chance of diet and exercise successfully getting them to a health BMI. For Morbid obesity it was 1:210. The saddest part was that even for those single minded ‘1s’ . 78% had put it all on again and more within 5 years.

This was my position. Because of years of yoyo dieting, I had made myself insulin resistant. Then came the miracle of Mountjaro. I went through the doses every month as prescribed. Once I lost the weight and was a healthy BMI of 22. I titrated down the doses until I arrived at 5mg weekly which is what I maintain on.

My GP could not prescribe as it wasn’t rolled out by the NHS when I started and when it was, my weight had decreased significantly so I couldn’t qualify - however she monitored my journey and reduced my medication to the point where I now take :
Thyroxine (half my previous dose) for life
Mounjaro 5mg.

This utterly baffling argument put forward by people that they ‘wouldn’t want to be on a drug for life’ tells me one thing. They are entirely ignorant of the health effects of obesity and just how much of the NHS resource Obesity sucks out of it. If you are clinically overweight or Obese the chances that you aren’t already on numerous drugs ‘for life’ already - is vanishingly small.

I have dramatically improved my own health and at my own expense cut the cost of the vast array of drugs supplied by the NHS to keep me in the status quo of obese but functioning.

Oh yes depression can be sorted by pulling yourself together and getting out for a walk everyday!

When some people can’t even get out of bed! 🤦‍♀️

I've decided to reframe my arduous trip into town in a more positive light by skipping into the shop whilst loudly asking if they have the jeans In. A. Size. 8.

I absolutely loathe all the pissing about with returning clothes, that sounds genuinely irritating!

Maybe some concern troll will start a new thread about it, make a change from the ones about unnamed friends in various medical professions/research posts, and colleagues who are on WLIs and have KFC every day.

The pain is real. I bought a pair of jeans in a size 10, got home and tried them on And. They're. Too. Big.

So now I have to trek back into town to exchange them and I hate going into town.

Damn you Mounjaro [shakes fist at the sky]

FWIW, a friend has just told me that he's moved from 'diabetic' to 'pre-diabetic' thanks to Mounjaro. (He's not yet at his goal.)

So many heartbreaking stories on here @HRTQueen. I've lit a candle for everyone who can now bear to look at themselves in photos. I hope we can get through it together.

I’m praying for you and myself going through a very similar traumatic experience

having to also suffer the side effect of feeling good about how I look again

I don’t even want to comfort eat that’s how bad it is 😉

Does he now? Best he doesn’t take them then.

He can have an opinion but he’s no more knowledgeable than anyone else not involved in the research, is he?

What are his thoughts on the positive effects for diabetics?

Sad, but so true. Still remember my GP saying admiringly that 'I was far better informed about HRT than they were' because 'It's not really covered in medical school.'

Considering he was near retirement it made me wonder if he'd bother to update any of his medical knowledge during the previous 30 years? Or just not bothered about HRT because, you know, it's only something to do with women.

Of course he is….

And my GP has had to consult his Clinical Reference Guide book for pretty much anything I’ve ever gone in for over the last 20 years, so I really wouldn’t expect him to be knowledgable about Mounjaro.

They’re called GENERAL practitioners for a reason.

Two of DH's golf buddies are GPs and they're both on WLI. So, meh......

Not sure that’s quite the gotcha you seem to think it is seeing how outdated they seem to be on women’s health, where it’s typical to diagnose even serious conditions as “fat” and/or “anxiety.

I’ve seen negative takes from GPs online and find them generally to be light on science and heavy on misogyny and fat-ist personal bias.

Have you asked him why? Seems a bit irrational otherwise. What long term effects worry him more than the long term effects of obesity?

Right...such as and based on what? Being a GP does not actually make him an automatic expert on every kind of medication and if you spend a bit of time on the WLI boards you'll find some scarily intelligent and v v well read mumsnetters who are exceptionally well informed on the latest peer reviewed evidence. Plenty of complaints on here about GPs who dont know anything much about a particular condition..that isn't surprising or a dig at your son but "being a GP" isn't a badge of automatic authoritative opinion.

Since only time will tell I don’t see the point of this post. People are stating real tangible benefits.

My son's a GP and has considerable concerns about the long term effects of these medications . . .

Just remembered another side effect. I no longer need my regular blood tests for cholesterol thus freeing up more appointments at my surgery for other patients. Should I be worried that I'm not getting my money's worth from the NHS?

Sounds traumatic!

I had the awful side effect of immediate reduced inflammation from my autoimmune disease which wasn't due to weightloss as it happened almost immediately within a week of taking my first injection. My rheumatologist agreed it was to do with the WLI and he was really interested in reading more studies on it. I also had the awful side effect of less brain chatter meaning my yet undiagnosed ADHD was manageable, making me more productive at work and at home. Also the side effect of 5 and half stone weightloss. I had none of the unpleasant side effects listed in the patient information leaflet. In fact, it has been a really easy process for me. The reduced pain and inflammation meant I was able to start exercising again after suffering immeasurably for years meaning my lifestyle was becoming more and more sedentary. I'm now in the gym 5 days a week and I love it there, it's really an enjoyable lifestyle choice for me.

I've had the unbearable side effect of needing a whole new wardrobe. Thank goodness for Vinted. Oh and I can comfortably tuck my jeans inside my wellies with room to spare. That and I can skip through my daily walk pain free. My blood pressure is right down, my visceral fat levels are excellent as is my bone density. Thoughts and prayers welcomed

I've been on it for 16 months. The only noticeable side effects have been the 3 st weight loss, the reduction in cholesterol and the disappearance of excruciating plantar facilitas.

Should I be concerned that MJ hasn't been working properly? Have I been injecting myself with a dud product???

@pollymere Strange how you aren't mentioning the many, many nasty and life limiting side effects of being overweight....?

Because they are legion.

You've stated all this as fact, so props to you for having such incredible self confidence.

I’m sorry to say, its just made you look a bit silly though…