Is it the begining of the end for Weight loss injections?

Gastroparesis is a symptom of gastric cancers, not a cause.

Unlike massive health problems that come with obesity? Assuming you reach an older age.

Well done or your achievements! Ignore the doom and gloom merchants!

My muscle mass is great and while I'm not an athlete, my performance has certainly improved - so much easier to run or do push-ups when not carrying a few extra stone.

All these posts worried about 20yrs time and when you get old, you do realise that being obese you may not have the privilege to get old? All the misinformation on here about food rotting in the tummy and losing lots of muscle. I have lost almost 7 and half stone and I havent lost much muscle and im lifting heavier than ever. Just because something happens to one person doesnt mean it will happen to everyone, sick to the back teeth of the nonsense pedaled by idiots on this thread. If you dont want to take the jab, fine, but leave others to it, jeeez, its not that hard. You dont need to make shit up to try and put others off using it.

@Hangerbout if this medication actually causes T2 diabetes, it seems a bit strange that it's used as a treatment for T2 diabetes. Can you explain a bit more about the evidence that it will cause T2 diabetes as people age?

When you were previously in a similar long term calorie deficit to lose weight, without using Mounjaro/Wegovy, what was the impact on your muscle mass and fitness then? I'm wondering about how that compares.

Personally, I would rather be at a healthy weight and take the risk of being "weak" and developing T2 diabetes as an old lady, than remain morbidly obese and probably not make being an old lady.

That's not been my experience at all. I've lost fat fat faster than muscle and especially visceral fat which is the most dangerous is now down to excellent levels. On top of the increasing evidence that weight loss injections reduce inflammation and the associated risks you certainly sound like an unusual case.

Worth pointing out that without WLIs, it's not a prediction but a certainty that we'll have massive health problems in a generations time. And now, and in two generations. Because that's what obesity does, and because sustained WLI use is the only proven way to reverse it.

My reactive hypoglycaemia I’ve had all my life even though I’ve not been overweight till menopause etc and then got pre diabetes- all stopped as soon as I started mounjaro! It’s sorted a lot of other medical conditions I have had all my life and apart from the monthly cost which I’m having to pay until the doctors sort it out on prescription I never want to stop the stuff as it’s been life changing! People will do all sorts to lose weight - but was one of them as a teenager who had anorexia badly- - but no one banned salt because people use it to make themselves sick when they have eating disorders did they 🤷‍♀️

Its a load of nonsense. This thread has really shown up a load of crap.

Also most people do not actually lose weight quickly they lose 1-2lb a week but consistently for a long period of time. This would be around a stone every couple of months (plus the usually 1st week or 2 whoosh like with most diets) so actually that does appear quick whilst it isnt actually. Same with muscle loss, this would happen to anyone losing weight without doing a lot of strength training alongside (which is recommended along with high protein diet when its prescribed).

I do wonder why people spout such rubbish.

They won’t be able to because it’s bollocks. Why do people purposely make themselves look so stupid?!

I’m a former amateur regional athlete who has diligently maintained some strength and fitness for over ten years since my peak. I’m definitely not at my peak anymore, but am probably stronger and fitter than the majority of middle aged women. I have many, many years of data to analyse.

I went on the drug for all of 5 months. It caused a straight line reduction in muscle mass. My power, speed, endurance also nosedived well beyond what could be reasonably expected with natural ageing. It was frightening to see the numbers drop so severely. It’s taken me the best part of a year and a half to build myself back up.

I stopped the drug because I had to conclude that, while I may have lost weight, I was setting myself up for some kind of rebound diabetes ten years down the line. This is because Muscle = metabolism. Strength also = bone health.

My fear is that the majority will not realise this is happening, even if they are an endurance runner, for example. Very few people push themselves to the max, therefore won’t clock the top slicing going on in their bodies.

I realise I might be an extreme example, but even so I predict massive health problems in a generation’s time.

I’m never going back on that drug. I’d rather be a bit fat, but strong and metabolically healthy, than slim and weak and with uncontrollable diabetes when I’m an old lady.

I lifted weights and ate a lot of protein and didn’t lose any muscle mass. Muscle loss is the same issue as with all low calorie diets where strength training is not a priority.

Can you point me to studies showing the cancer risk please? I don’t have “rotting food” in my stomach - I j have regular bowel movements.

@T1Dmama does food rot inside the body? I've never heard of this before. Wouldn't we all have sepsis if that were the case? Where did you find out about this phenomenon. I think you should share this important medical information please.

@T1Dmama honestly where do you get all this invented stuff from? What evidence do you have of a connection to stomach or bowel cancer? Food does not sit rotting in your digestive system, that’s a total nonsense.

I’m also interested in how you come to a different conclusion from the MHRA in the UK who carefully analysed all the data and came to the conclusion that the risks are outweighed by the benefits for anyone who is obese. Not just morbidly obese, but obese or even overweight with weight related health issues. You seem to think they are wrong but you’ve not explained your reasoning.

I’d be really interested to read the research into delayed gastric emptying causing stomach cancers please - I’ve had a quick google but nothing has shown up.

Loosing weight quickly is bad, because if you loose it too fast your body burns fat for energy but also looses muscle tone and your body feels fatigued.
when you stop using the injections and regain the weight, you regain the fat but not the muscle…. So then your body has a higher percentage of fat than before and lower metabolic rate than before before muscle burns fat!
Also the way in which these injections work
is to slow down digestion, which in turn slows down the absorption of glucose into the blood (which is the diabetes side
of things) it also works by reducing the resistance the body has to insulin.. the side effect is feeling full or feeling sick if you over eat as the undigested food seeds festering in your bowel/stomach…. It is reasonably well known in the medical field that these injections carry a long list of health risks BUT when used short term to reduce someone’s insulin resistance and put their type 2 diabetes into remission, the risks type 2 diabetes carries long term out weigh the risks of the injections short term!
Type 2 diabetes carries risks and increases your chances of developing so many illnesses due to the strain on the whole body and nervous system that comes with having high/low blood glucose… so it is deemed ‘worth the risk’ putting diabetic people in these injections if they lower these long term risks.
The same could be said if a patient is morbidly obese I guess, however it’s a short term fix and not really worth the increased health risks of being on these injections long term.
The issue comes when people who are only a bit overweight are lying on line to get these injections to loose and keep off weight, hugely increasing their risks of muscle mass loss, bowel cancers, stomach cancers (from the rotting food sitting around in their stomach or bowels longer than it should) … also risk of bowels becoming lazy/giving up .. I believe it is predicted that lots of these people abusing these injections and not being monitored by a GP ay end up with stoma bags later down the line …
Its fairly obvious really that slowing digestion and having all that rotting food sat in acid in your stomach and intestines for longer than it naturally should be is bad bad news!!

They are essentially competing against themselves.

@SilenceInside they are, but given this is very early days in terms of the markets for this class of weight loss drugs, they’ve also got enormous potential to grow the market (i.e. reach lots more people) by pitching different products at different prices. Especially a product that almost sells itself in terms of patient demand. You need to go back to the launch of Viagra to see something similar in tens of impact.

I think there's some confusion around the tablet form of semaglutide. There has been a tablet form around for a while in the UK called Rybelsus. It's at a lower dose than the new Wegovy tablet that hasn't been approved yet, but that's the only difference. Rybelsus is not approved in the UK for weight loss, only for T2 diabetes control. Some pharmacies and doctors will prescribe Rybelsus "off label" for weight loss, but it isn't very common and would be on a case by case basis where there would have to be a medical reason for not using the Wegovy injections instead.

The new Wegovy tablet has just been submitted for approval in the UK (www.reuters.com/sustainability/boards-policy-regulation/uks-pharma-regulator-could-issue-decision-novos-wegovy-pill-by-year-end-2026-01-05/) . It has just been approved in the US by the FDA, and has been submitted to the EU panel for approval. It might take around 3 to 6 months to be approved in the UK. Then it would take another 1-2 months for pharmacies to be able to order it and get it in stock. So realistically you're looking at mid-2026 at the earliest, probably later in 2026 or even into 2027.

The prices for the new Wegovy tablets in the US have been announced as $149 per month for the lower doses, and $299 for the higher doses. I think the pricing in the UK will be interesting, as if Novo Nordisk make the tablets too much cheaper than the injections then they risk wiping out their own sales of those. They are essentially competing against themselves.

Sometime this year. One poster earlier said they have already been prescribed them

Thank you.
I really hope you're right.
Although I'm worried that the pharmaceutical companies will still market them at an over inflated price purely because of what they are.
I've never felt so well in myself as I have done since using a GLP1. It's done so much more for me than the weight loss and it has resolved a list of medical problems. I want to use it forever, but with the recent price hike of MJ, this will be my last month of using it sadly due to the cost.
So I hope you're right about the tablets.
When are they coming?

As someone who works in pharma, we are looking to develop the most effective treatments possible, and a cure would be the holy grail. This isn’t altruism - effective treatments can charge more and are more likely to get approval. If someone had a cure for weight management you can bet they would bring it to market and charge a premium,

They will definitely be less. It's a lot cheaper to produce tablets than injectable liquid. The smaller volume they take up, the lack of refrigeration required, easier storage, means that once production ramps up, they will be an awful lot cheaper.

How much do you think these tablets will cost? In comparison to MJ?

I've always been staggered by those stats too @DarkForces. Read once that in the 1950s, the NHS issued more prescriptions for barbiturates than penicillin! It's so dangerous, I don't think it would be given now unless in very extreme circumstances, but back then it was a way of calming and shutting up women who had 'trouble with their nerves' (I'm guessing the majority were just suffering menopause symptoms and terrible marriages).