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Original poster

Sertraline 14 days positive stories please

169 replies

Francis24 · 23/04/2025 13:25

How long before sertraline made you start to feel better depression? I've been taking it 14 days 25mg positive stories please

OP posts:
whatisforteamum · 26/04/2025 06:59

Following as I have SAD so feel ok in the spring summer but dreadful in the winter.
I want to take them but dreas the side effects.

beachcitygirl · 26/04/2025 04:11

I’m on 100 mg - it’s keeping me alive. Hang on in there if you can.

FishyMcFishyfingersFace · 26/04/2025 04:10

It really does depend on the individual taking it for how well it works.

Unfortunately for me it hasn't helped hugely, have been on it over a year and am on 200mg a day. It is better for me than the previous 2 kinds of antidepressants I have tried though. What has been better for me is quetiapine, but that had to be upped to 300mg (150mg twice a day) to have a noticeable effect. (I have a meds review next week and will see what the doctor does with the medication.)

Just give it time and make sure you go to your GP or other suitable health professional if you have undesired side effects.

Jumpingthruhoops · 26/04/2025 02:05

For me, five months at 150mg and I was back to normal(-ish)...

Moomoo75 · 25/04/2025 22:58

When do you take your dose? I take mine at night as I was warned I could feel drowsy. I start work v early and was afraid if that happening. But how do others find it? I started on 50 and was upped to 100.

Choccy11 · 25/04/2025 22:46

I started on 25mg for a few days then up to 50mg. I may have been lucky but I had no side effects and after 2 weeks I realised I no longer felt like I had a gun to my head. Still on 50mg years later.

MarxistMags · 25/04/2025 22:32

It was 3 weeks and I woke up and it was as though a weight (literally) had been lifted from my shoulders.
I still take them, 10 years now. No one has asked me if I want to stop and I'd be wary of doing so now. 50mg.

Hillsmakeyoustrong · 25/04/2025 22:20

That is good news OP. When I hit 50mg I felt the benefits hut my SIL had to increase even further. Its very individual. Keep us posted and good luck x

Original poster
Francis24 · 25/04/2025 10:58

Hello, I've just upped from 25mg to 50mg as my GP Said 25mg is such a low dose and I would feel the benefits I need. I told her I feel so low still. Any experience going from 25 to 50mg positive stories please

OP posts:
Original poster
Francis24 · 23/04/2025 15:11

I meant what dose?

OP posts:
Original poster
Francis24 · 23/04/2025 14:47

What does is everyone on?

OP posts:
loveyouradvice · 23/04/2025 14:36

Doctors are always cautious and say it takes 4-6 weeks to kick in - different people react differently.

For me, I noticed no difference at 6 weeks. They then upped my dose moderately (and I wasn't optimistic) - Lo and behold at exactly 5.5 weeks from the increase, I woke up feeling very different and the effect has continued since.

MrsPositivity1 · 23/04/2025 14:33

Sertraline changed my life but it took about a month to kick in. I just woke up one morning feeling alive again

Original poster
Francis24 · 23/04/2025 13:46

I have my mum and partner with me nearly all of the time. I do think I have felt more depressed but I've read your can get worse before better. I'm at my GP tomorrow I'm think she may up to 50

OP posts:
Milly16 · 23/04/2025 13:40

Changed DPs life but took time to grt the dosage right. He's on a much higher dose than that. Hang on in there. Also, sadly it can trigger suicidal feelings in the first few weeks. If that's you, please let your doctor and people around you know asap

Original poster
Francis24 · 23/04/2025 13:36

Thanks all for your responses. I've been in 25mg and the doctor mentioned it is a low therapeutic dose so that's maybe why I'm not feeling the relief yet? Also it's only been 14 days

OP posts:
vincettenoir · 23/04/2025 13:32

I started on 50 and it worked for me literally from day one. I don’t think it can actually take effect that soon so it may have been a bit of a placebo effect at the start. I hope things turn a corner soon. Hopefully in a week or two you might just suddenly notice the difference. Good luck,

Dotjones · 23/04/2025 13:31

People noticed the change in me after three or four weeks. I didn't really feel any different but other people saw the improvement, people commented on it who didn't know I was taking it.

You might find like me that the dose needs to be increased before you feel a difference yourself. This is normal, doctors start you off slowly and build up to the level you need. It was particularly noticeable when I went up to 50mg, not noticeable when I then went up to 100mg, but noticeable again when I went to 200mg.

It's not a "quick fix" drug in that it takes time to build up in your system and doesn't bring on a sudden dramatic change to your personality or thinking behaviours. But that's also a benefit, it doesn't feel like you're "drugged" or anything, which some antidepressants can do.

Stick with it.

Hillsmakeyoustrong · 23/04/2025 13:28

Hi 👋 I started on 25mg like you, for a few days, but it was when I went up to the normal dose of 50mg that I felt better, maybe after 2 or 3 weeks. Initially I felt seasick and like I was wearing a really tight swimming cap but one day I woke up and the side effects had gone.

Best thing I ever did. I've been on them 5 years now.

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