to think more negative effects will come out from Ozempic use?

Ok then explain why you feel like this, after 15 years of trials and 20 years of use, and multiple health authorities globally approving. Can you explain it?

I suspect for many posting it is a cosmetic issue for them. Hence we see responses like this.

I’m not trying to beat people with a stick for using Ozempic/Wegovy/Mounjaro as a weight loss drug. I also doubt they will ever be withdrawn and may well be expanded for other conditions in future. But I also think that more negative effects may come to light which is the title of the thread.

@lettyraines

It's as if you are saying their bodies are doing this odd thing of tending to gain weight, with no input from the person inhabiting the body.

No, but once your fat cells have been damaged by obesity (which yes, is caused by eating in excess of caloric needs over a significant period of time, whatever the reasons for that may be) they both expand and multiply, which impacts the body's metabolism and hormonal response, making it harder to maintain weight loss as the body is actively fighting to regain the weight. The damage is caused by the person's initial actions ie overeating, but once the damage is caused it is very hard to undo.

I think, also, it has been established that most people will gain back most of the weight they have lost on WLI once they stop the injections. So...

Yes, that links to the point made above. There is little research into the long term treatment of obesity but these drugs will enable better research to be carried out which will help us understand if/when the body recovers from these effects and people with obesity are no longer at greater risk of becoming obese again.

Lottie moss got the drug from a friend of a friend. She also took a much higher dose than even if she was eligible would have made her very unwell. She was not prescribed it. Can you find no one who has taken the drug legitimately and suffered an issue? So it’s just some minor celebs who got on the black market?

But if your BMI is in the overweight range ( has to be over 27) the only way you are getting the drug legally is if you already have a weight related condition. Implying that yes your weight has already began to impact your health.

Obesity, even class 1, has a detrimental impact on health. We have normalised it so much that we think of it as a cosmetic issue. It is not it is medical and increases your risk of a variety of secondary conditions. And decreases life expectancy.

This is not a cosmetic argument but a medical one.

But no one knows this, how could they, no one can see into the future, how can we even have a discussion on it.

what we know is the drugs were in trials for 15 years, that the peptides have been in common use under different guises for over 20 years, that over 17 million or on them in the USA alone and not one death or serious illness directly attributed to the drugs, that the testing requirements since thalidomide have been highly tightened up, hence why it is 15 years of testing and trials post development.

does this mean something won’t come out in another 20 years and that 35 years isn’t enough, no, but asking people to speculate in will something appear at some point is just daft especially when it is people with limited knowledge of the drugs never mind a scientific or medical background.

look at the op, she actually seemed to think the drug caused the osteoporosis, even though the article clearly stated otherwise, we have seen multiple people who don’t understand the drugs, don’t even know the prescribing guidelines.

it’s clear the people taking them are the ones who have researched and are the most knowledgeable and the people who are posting the negativity have not.

sure we will all engage in a discussion on the validity of testing from the authories, be it the fda, mhra or any other market you wish to look at, be in China, or France, whatever. But it is clear the people posting simply don’t have the knowledge to do this, so pretending we can have some sort of debate on the testing methodology of prescription drugs is silly.

Since 1995?

https://www.bbc.co.uk/news/articles/cz6jg6nw2zeo.amp

Lottie Moss is someone who comes to mind as she was never overweight & suffered very bad side effects to the extent of being hospitalised.

Perhaps because the thread is about Ozempic? I’m concerned about alendronic acid.

Well, I guess they have a different opinion to me.

This class of drugs have been on the market for 30 years. So from a drug development point of view we have 30 years of data.

The known side effects are worth the risk. The possibility of unknown side effects emerging seems to be used a stick to beat people. I am not saying they won't emerge but given the long term existing data it is unlikely they will be see enough to warent withdrawal.

In fact more likely is the drugs use will be expanded for a variety of other conditions

It's not the drug causing harm, it's people's misuse of it that does the harm.

@lettyraines why do you think the MHRA came to a different conclusion, that GLP-1s are appropriate for people with Class 1 obesity or overweight (BMI > 27) with weight related health conditions?

Absolutely, for morbid obesity. But for, say, class 1 obesity, I don't think they do. Certainly, if your BMI is in the overweight range, in my view it is madness to take such risks with your future health. But of course people do.

I think the fact the op deliberately excluded the positives, shows she’s not interested in a balanced discussion.

I completely agree with that.

This thread though is about the long term effects of using weight loss drugs and whether we think more negative effects will come out in future or not.

@Twiglets1 which celebrities who don't meet the prescribing criteria have been prescribed WLIs by an online pharmacy? I've seen cases where celebrities have been prescribed in the US, which has a totally different healthcare model to the UK. I've seen cases where celebrities have used substances bought from beautician- type sources which could be anything and certainly aren't the licensed medication made by Novo Nordisk/Ei Lilly. I've seen cases where celebrities have been given medication by a friend of a friend passing on their prescription medication. Just wondering which examples you're thinking of?

The guidelines for pharmacies have been clarified which I'm glad about. Most prescribers meet the clarified requirements. Certainly the one I'm using has not had to make any changes to how they prescribe and what checks they do.

All drugs carry side effects / risk as stated over and over again. The risks of obesity far outweigh the risks of the drug.

Yep and here's the part of the abstract you omitted
"Compared to usual care, GLP-1RA use was associated with a reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia), coagulation disorders, cardiometabolic disorders, infectious illnesses and several respiratory conditions."

Is this supposed to be a ‘gotcha’? Not one person has said these drugs don’t have possible side effects or that some others may become apparent in the future. But that if you’re taking this medication, you’ve weighed up the risks compared to being obese and decided it’s worth it.

@nameey both of those issues have already been discussed in detail on the thread already.

Criticising online pharmacies that dispense weight loss drugs to slim people pretending to have a weight problem obviously isn’t right. This practice does happen as is clear from certain celebrities. It obviously is possible to game the system with online consultations although most people are honest I’m sure.

Im not criticising all current prescribing practices or claiming to be an expert. But if they’ve recently tightened up the rules that suggests they felt they needed to as there were problems with the previous ones.