This shows you (and other posters like you) do not understand how they work - their impact on insulin IS known, that is HOW they work. They control the out of whack insulin response to carbohydrates that many men and women experience - they may be pre-diabetic, have a genetic predisposition to diabetes that means insulin is resistant to carbs, they may have PCOS, hypothyroidism (these two present together in over 70% of incidences), be menopausal.. and so on. ALL of these things are endocrinological dysfunctions that mean that the over simplified calories in/calories expended model is inaccurate and that diet/excercise alone to not work. Note the use of ALONE. People using these medications have dieted/exercised just like successful dieters, often over decades. And for many it worked for a big chunk of that time. Until one day it does not because … menopause, PCOS, Hypothyroidism etc changes in the way it impacts the body as you age.
Thyroid cancer was seen in one rat study, hence the precaution of not prescribing to individuals who have a family history of thyroid cancer. My family has a history of hypothyroidism - all my sisters and I have it, along with PCOS; my 16yo son also has hypothyroidism; and we have all been prescribed Ozempic or mounjaro in the last year to not only find that the same agonising exercise regimes and diet programs that everyone else follows finally work again for us… oh, and our thyroid medication has been reduced (and we’ve come off diabetic medication for PCOS too).
Am sick of the ‘take the jab, the fat melts off and as soon as you stop taking it you’ll regain it’ narrative. A study of 22k ozempic users and 22k mounjaro users showed that 56% dieters kept all/most of the weight off after 12m, compared to 95% of traditional dieters who regained some or all their weight in the same period. In fact less than 26% regained all the weight, making it more than 3.5x more successful for long term weight loss and management. It is successful because it helps recalibrate insulin response long term and because you have to completely change your relationship with food/diet/your body in order to lose the weight and this remains after you titrate of it.
Just as anti depressant medication can be stopped and a return of symptoms avoided, if you do the counselling/lifestyle changes that support recovery, these medications are a tool, not a cure.