I've done this. DH & I sold everything we owned, rented out our house and bought a one-way ticket to Asia.
Full-time travel is HARD. You still have to eat well, get about, get clothes washed, work out language/currency/culture differences and you need energy in abundance to enjoy sightseeing too. And deep pockets if you want to have a good sleep in a clean bed every night. You need to make dozens of decisions every day, more so than at home.
I'm glad I did it, but after 12 months travelling Asia & Europe I was DONE. I wanted my own kettle, a bed with my own mattress and a nice local shop. More than that, I missed routine. It messes with your head.
I don't believe all those perfect Instagram accounts, every long-term traveller I met was knackered and repeated the same conversation over and over - 'have you been to X? Don't bother' 'Oh you'll get ripped off at Y if you're not careful' etc etc. Very jaded and wary.
Being away for a year, friends and family of course carried on and I found it really hard when I returned to get back into their lives; done friendships never got back on track and this was totally unexpected.
Now I go for trips no longer than 6 weeks, my absolute limit! But honestly, having holidays of 1-2 weeks to places you really want to see and doing it WELL is much, much preferable. Do a cruise if that's your thing, have a break, recharge.