Placebo though is a big bag to put all the different things that actually DO make a difference but we haven't a clue what they are.
It can be talking, the colour of the drug, the nice reassuring pharmacist, knowing you ARE doing something.
It's not because we don't actually now which one of these it is or because it's not a molecule of some sort that it doesn't make a difference.
The problem, on a research pov, is that you can't replicate it easily so it doesn't fit studies.
Personally, I would choose a good dose of positive placebo effect over any drug (Really less risk tbh)