Aspirin in early pregnancy - does it reduce or increase risk of early miscarriage?

(21 Posts)
Emwils Thu 10-Dec-20 11:12:08

Hi everyone, I hope somebody may have some thoughts to share on this one...

I've had two early MCs this year - one in March, one in June, both between 6 - 7 weeks. I'm really pleased (and also terrified!) to be pregnant again now (4+2 so very early days still - fingers crossed!). If this pregnancy succeeds it would be our first DC. I'm 35.

As the NHS wouldn't refer me for miscarriage advice until I'd had 3 miscarriages I decided to seek help in the private sector, and saw a private ob/gyn. She has prescribed dispersible low dose / baby aspirin daily, along with daily cyclogest pessiaries. I've seen so many positive stories on here indicating that baby aspirin may help women who've suffered from previous MCs to carry pregnancies to term, and it seems to be a fairly standard course of treatment. However, I've also come across a few rather alarming references via Dr Google, which indicate baby aspirin may in fact INCREASE the risk of early MC?! I've pasted two of these references below:

If you need to be on aspirin, it should not be started before 8 weeks
of pregnancy. There is evidence that taking aspirin whilst trying to
conceive and before 8 weeks of pregnancy will have an adverse
effect on implantation. For this reason we recommend that you do
not take aspirin unless a recurrent miscarriage practitioner has
advised you to do so. (https://mft.nhs.uk/app/uploads/sites/4/2018/04/12-123-Recurrent-Miscarriage-Service-January-2015.pdf)

Recent evidence suggests that Aspirin may increase the relative risk
of early miscarriage and for this reason clients are now advised to
stop low-dose Aspirin just before embryo transfer and not to take it
in early pregnancy. (https://www.zitawest.com/wp-content/uploads/2015/06/Reproductive-Immunology.pdf)

So basically I am now very confused about whether to take the aspirin after all - will it help in my situation, or will it potentially make things worse?! Needless to say I've asked my doc this question too, but she only works in private practice one day a week so I may not get a quick response...trying not to panic, but I'm so worried about potentially losing this baby because of taking or not taking something incorrectly, i.e. whether or not I lose this baby could be preventable :-(

Any thoughts, experiences (or advice from your own doctors) would be very welcome - thank you ladies :-) x

OP’s posts: |
Starlive23 Thu 10-Dec-20 12:27:27

Stay away from Dr Google OP and if you trust your doctor and she seems good ie not a sort of cowboy doctor, then I know it's hard but try to trust her.
Most early miscarriages are caused by chromosomal issues and if you have any questions you could always give EPU or midwife a call.
It's so, so hard not to google. But it can cause untold levels of anxiety throughout the whole pregnancy. Good luck with the pregnancy op x

turnthebiglightoff Thu 10-Dec-20 12:33:45

I was put on aspirin as part of a trial to reduce the possibility of pre eclampsia are 12 weeks and told to continue for the whole of my pregnancy; I got a blood clot at 28 weeks so was taken off of them. I doubt that the blood clot and aspirin were linked, but I was told they were very safe in pregnancy.

donttouchmyhair Thu 10-Dec-20 13:03:29

turnthebiglightoff

I was put on aspirin as part of a trial to reduce the possibility of pre eclampsia are 12 weeks and told to continue for the whole of my pregnancy; I got a blood clot at 28 weeks so was taken off of them. I doubt that the blood clot and aspirin were linked, but I was told they were very safe in pregnancy.


Aspirin is an antiplatelet, so reduces clotting of blood.

Grognonne Thu 10-Dec-20 13:22:10

I am under the care of a consultant as part of the recurrent miscarriage clinic. I have been prescribed aspirin and cyclogest and was instructed to take these as soon as I got a positive test. Seems to be working so far! Aspirin is often prescribed to pregnant women.

welshladywhois40 Thu 10-Dec-20 13:39:43

Hi - this is such a tricky subject as you want to do everything you can to prevent another miscarriage and just sometimes there isn't anything.

I had two mc before this pregnancy and thought should I be doing anything to protect this pregnancy. As it was only two (which was still devastating) I was under anyone's care.

When I eventually spoke to a midwife (she couldn't see any reasons (week 10) to take anything. Ditto with my consultant - I am only seeing a consultant due to my age.

So touchwood we are now at 33 weeks with no aspirin or progesterone.

Emwils Thu 10-Dec-20 14:02:13

Thanks so much ladies, your replies are all really helpful.

@Starlive23 I know you're totally right about Dr Google, but it's so hard to resist sometimes when you just want to make sure you're doing everything in your power to prevent another mc...

That said, @welshladywhois40 you're also right that sometimes there just isn't anything one can do (and I'm sorry to hear about your two previous losses. Exciting to hear you're now at 33 weeks though - congrats!).

Good luck with your pregnancy @Grognonne (and sorry to hear about your losses). Sounds like I will probably be joining you on aspirin and cyclogest then!

OP’s posts: |

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turnthebiglightoff Thu 10-Dec-20 14:43:46

Thanks @donttouchmyhair I knew that, I was just saying why I was taken off of it.

Moo678 Thu 10-Dec-20 14:45:39

Hi OP - I’ve had 7 miscarriages in total and am under the care of the recurrent miscarriage clinic. I was advised by my consultant to take aspirin from my positive test. She gave me progesterone too but only to be used in the case of threatened miscarriage. Mine said the evidence for the Benefit of aspirin in recurrent mc isn’t great but there’s no evidence to suggest it’s harmful. Sorry i don’t have time to read the links you posted but I’m confident my consultant has done the research.

Anecdotally, I’m now 14 wks after taking aspirin for the first time so It did work for me.

Aria2015 Thu 10-Dec-20 14:58:59

I took baby aspirin after miscarrying my first and second pregnancies. I was taking it when I conceived and took it all the way through my 3rd pregnancy (which was my first successful pregnancy). I was told that baby aspirin can increase blood flow to the uterus and so is good for conception / early pregnancy? I took it for my fourth pregnancy from conception also but that pregnancy ended in miscarriage and I took it again from conception to birth for my fifth pregnancy, which was my second successful pregnancy.

So for me I feel like it's been good as I've had two successful pregnancies on it. Hard to know if it made the difference but for 2 of my 3 losses I wasn't taking it...

I would go on the recommendation of a medical professional over google though. Wishing you lots of luck!

3rdtimelucky2019 Thu 10-Dec-20 15:05:11

My only successful pregnancy so far was with baby aspirin. I'm 11 weeks now, taking baby aspirin again and find out Wednesday if it's been successful too.

ThisMammaCat Thu 10-Dec-20 15:16:31

Twice I've decided to take low dose aspirin after a BFP following a loss. One of those pregnancies is now an 8 year old, the other is 18 weeks so far and seems to be going well. I just want my blood to be as good as possible for nourishing my baby. I've not told the midwife I'm taking it because she might tell me to stop and that is something I won't do til I'm not far off being due.

HungryHippo20 Thu 10-Dec-20 15:30:11

I also had 2 miscarriages in the last year and after lots of reading I decided to take 75mg aspirin daily from my BFP. At my booking appointment the midwife doubled it to 150mg due to me being 40 (standard apparently) I'm now 27 weeks pregnant. I guess I'll never know but I firmly believe aspirin helped. Previous pregnancies didn't get passed 8 weeks. The midwife said it wasn't any any way harmful in fact now they recommend a slightly higher dose in pregnancy

Snapcat Thu 10-Dec-20 15:36:14

Personally I wouldn’t take aspirin from bfp unless advised. I had a subchorionic haematoma which was touch and go whether it would cause miscarriage by getting bigger and dislodging the embryo. I was told aspirin would increase the risk of this.

HungryHippo20 Thu 10-Dec-20 16:41:11

Agree @Snapcat it has to be a personal choice, mine was entirely my decision and turned out to be the right one for me

Snapcat Thu 10-Dec-20 17:16:24

@HungryHippo20 Absolutely, it’s so hard to know what to do and there’s rarely a right or wrong. Congratulations on your baby.

HungryHippo20 Thu 10-Dec-20 17:20:04

Thanks @Snapcat 😊

Sitchervice Thu 10-Dec-20 18:13:13

@Emwils hi i may have to take aspirin soon due to something about short placenta ect. I have a whole leaflet about aspirin and pregnancy given to me by my midwife if you want a copy?

Jobsharenightmare Thu 10-Dec-20 18:22:37

I paid for a private consultatation and the fertility specialist told me if I had taken matters into my own hands I may have caused the miscarriage I was trying to (ignorantly) prevent. If you can't afford to do the same, don't risk it I say.

You don't want to regret trying to be your own doctor.

Jobsharenightmare Thu 10-Dec-20 18:25:38

Sorry that posted too soon! So talk through your worries with the prescriber and don't go off these replies. Your baby's safety depends on sound advice

Best of luck.

6weeksandscared Wed 16-Dec-20 15:50:37

Hi ladies. I wondered if anyone could help-im in the same position as OP but I have been prescribed 150mg of aspirin. Have had two ms one at 6 weeks and one at 12 weeks. Is anyone else taking this high a dose? And are you talking it in one go or splitting in to two doses? Also been prescribed clyogest and have started taking it as I am spotting. Sorry it's a bit long..this is all a big successful

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