Advice on where to go next/what to do after 5th miscarriage.

[madharri123]

I have just received the karyotype analysis from my 5th miscarriage. It was trisomy 22 (like my 4th - these were the only 2 that were tested). I am now 39 (and three quarters!) years old.

This last miscarriage was under the Coventry Clinic. I went for Natural Killer cell analysis (which was negative) but was diagnosed with hyper fertility and followed their protocol for hyper fertility (progesterone pessaries from 7dpo. They have advised me to look into preimplantation genetic screening (PGS). Does anybody have any recommendations or advice as I’m feeling rather lost.

[madharri123]

I should add - we both had genetic screening after our 4th miscarriage, which was also a trisomy 22 x

[Beesandfrogsandfleas]

Hello, I don't have any advice of this scenario but wanted to say I may sorry for your losses. I had four mcs but for me it was related to natural killer cells. Just thinking, there is another section here called Conception with people who have been through more on the ivf side of things so might be worth putting a thread there?

[madharri123]

Thank you so much x
I’ll head over and take a look

[allthatmalarkey]

Sorry, no advice either, just wanted to offer Sounds like you are at least narrowing things down. I'd say Google like mad to learn as much as possible, but I suspect you're doing that already.

[madharri123]

I thought I would just return and update in case anyone stumbles across this post Looking for info on hyperfertility and progesterone (like I was). After my 5th miscarriage Coventry increased my progesterone pessary strength from 200 up to 400mcg twice daily. I fell pregnant straight away (which is obviously a bad sign) but my 6th pregnancy went to term and I had a little boy, now 9 months. I will never know if it was just a numbers thing and I had to strike it lucky at some point anyway but I cannot recommend Coventry enough. I dealt with Prof Brosens and he was just great - so professional and very caring. From my first phone call to Coventry it was like night and day compared to my (pretty shitty, completely empathy-free) experience at my local NHS and Kings hospitals. Good luck xxx

[Mysleepingangel]

Hi

@madharri123 I'm so so glad you had your rainbow baby and are now content. I pray for your happiness and more cute, healthy babies in the future (if that's what you want, of course!)


Big hug to you xx

Love
H