I thought they started off brilliantly (especially the first one, Interview with the Vampire) but the standard of her writing has declined over the years, to the point that now when she brings a new one out I don't bother reading it any more. She is just churning them out now, I think, but the first three or so are definitely worth a read.
Sorry just twigged you could have meant should you start reading them, are they any good, before feeling like you have to finish them just to see how it all ends. If you get bored of them, but have to know, google the plots of the other books? I did this with 50 shades of grey, couldn't bear to read any more but went on google/wikipedia to see how what happened next/the final outcome.
Read a lot of the chronicles. Didn't read them in order, read some and not others. Didn't find that it was a problem. I do have a few that I never got around to reading that are on my to read pile. But that pile is a tad large and they are a way down the list
I would really recommend the first three, they are fantastic. Some of the other chronicles are sort of stand alone books featuring characters from the main trilogy so you don't necessarily have to read those in order. Blood and Gold is my favorite stand alone one.