Maybe she would be better with more hands on help? has she spoken to her GP? She doesn't really have an empty nest if she has 2 children at home and one at university it sounds more like she is going through a really hard time and needs support.
Can anyone one recommend a book I can give my sister who is getting more depressed. Her eldest has going to uni and her ds1 has had to go to an adult care home as he is severely autistic and became violent. She has 2 more children at home. I understand that no book is going to spring her back to her old self like magic but if anyone has read anything worth recommending to her it can't do her any harm.