Yes, I had persistent, PCOS-related spots until my late 30s, when I discovered La Roche Posay Effaclar range, which totally and utterly transformed my skin. It is now consistently clear, and I get complimented a lot about how good it is. I cannot adequately communicate to you just how much this changed my life, which you will appreciate i'm sure, as adult spots make you miserable.
I just use the face wash twice a day (I wear a full face of make up, and I use this to remove it at night, works fine), with a muslin cloth. I use an eye cream, and then I use the Effaclar Duo moisturiser in the morning, followed by primer/foundation etc. In the evening, I use a richer cream, sometimes with Effaclar Duo underneath to make sure my skin stays clear.
These products cleared spots that I had had for 10 years+. Miraculous.