I don't mind adverts generally, but there are a ccouple that are talking to me without a rollover -- one is for dettol I think. It is frightening and makes me think I am in Bladerunner. Is it an accident?
I find anything which starts audio output by itself a major annoyance.
Not only can it muck up recording something else (I nearly always have something being recorded and disable/don't run anything which 'bings' or 'bongs' at me), but at 3am can be really annoying if you happen to have the audio level high on your stereo amplifier and then wake the household with a few hundred watts of sound !
I often browse with a Firefox add-on to block Flash 'movies' from playing but even so, it does not block out all unwanted sounds.