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Trisomy 15

(7 Posts)
Standingcat Wed 01-Nov-17 15:07:11

Just had an appointment with a doctor for recurrent miscarriage, my consultant wasn't available so saw another one and had to summarise history for them. They are running loads of blood tests and then realised at the end of the appointment that they had the genetics from tissue testing after last ERPC.

Baby girl had Trisomy 15 triplicated, I don't now much about this and have some questions, can anyone help?

I have a healthy DD so does this mean that the Trisomy 15 gene is unlikely to have been parental genetic issue? as in our Trisomy 15 is normal and that on this occasion it mutated?

I understand that either egg or sperm may have carried an extra Trisomy gene, does this mean that IVF could be an option?

Has anyone gone on to naturally have a healthy baby after having a loss caused by this? Could I?

The doctor said with Trisomy 15 the outcome would never be a full term baby, yet I have seen stories online about DC alive with issues from Trisomy 15?

OP’s posts: |
Standingcat Wed 01-Nov-17 15:30:12

Another question, could my DD have any issues with her Trisomy 15 chromosome and its not been detected? she is 5 and has normal development.

OP’s posts: |
Tempranillo Mon 06-Nov-17 19:43:09

Hello, I'm sorry for your losses.

Trisomy 15 means that your baby has three copies of chromosome 15, rather than the normal two copies (one from the mother and one from the father). In the vast, vast majority of cases this happens purely by chance rather than due to a genetic issue in the parents. There is no 'trisomy 15 gene'; a chromosome is a piece of genetic material which contains lots of genes.

Sadly trisomy 15 is incompatible with life.
It would be incredibly unlikely for this to happen again.

Tempranillo Mon 06-Nov-17 19:46:51

And no, your DD won't have undetected issues.

ferntwist Tue 07-Nov-17 23:28:50

Hello Standing and so sorry for your loss. I also had a miscarriage of a Trisomy 15 baby. The hospital tested my chromosomes and my husband's afterwards because we had previous losses (I had a uterine septum) that were unexplained. We were both found to be perfectly chromosomally healthy. They told us that this meant the Trisomy 15 miscarriage was just a random event that occurred at conception. Apparently that is the case for the vast majority of people, especially if you have not had other losses.
Trisomy 15 is incompatible with life - the consultant was amazed I had carried the pregnancy to 11 weeks. There is another condition caused by a much smaller defect on chromosome 15, but this is not linked. I would be extremely surprised if your daughter had it as I read about it a lot at the time and it causes serious physical and mental disabilities that you would have noticed during her development.

Our doctors all told us that unfortunately trisomies are quite common in older mothers and are no indicator for poor outcomes in your next pregnancy.

Good luck!

ferntwist Tue 07-Nov-17 23:31:37

Just to add as well that we had IVF afterwards and I got loads of eggs and seven chromosomally normal embryos (we had them all tested) and not one of the abnormal ones had Trisomy 15, so I am sure it was just a freak occurrence for us and hopefully will be for you too.

shwemah Tue 08-Jan-19 10:42:01

Hi, I am 34 yesars old, I had terminated my first pregnancy at 20th week due to Diafragmatic hernia from US and done Karyotype which has resulted Diaphragmatic Hernia with Ambigous Genetalia and Fish Analysis has failed.
My second pregnancy terminated at 8th week due to Missed abortion as no cardiac activity( Cytoprime Microarray Resulted-Trisomy 15). Will there any chance of recurrance in next pregnancy as our (both parents) karyotype is normal

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