low dose aspirin, progesterone pessaries and metformin to prevent miscarriage?

[inamaymaybewrong]

We're TTC #2 after IVF for our son 4 years ago, I've just had my second miscarriage. I have thin, ovulatory PCOS but all other tests were normal so our primary infertility was classed as unexplained.
We lost a frozen embryo cycle pregnancy last year at 6+ weeks and our clinic put it down to bad luck / possible chromosomal abnormality.
By some miracle we conceived naturally in April after I had been taking metformin for just two months. I'd never had it before. Maybe coincidence, maybe not?
I miscarried that pregnancy yesterday at 9 weeks. Tests are being recommended but privately as NHS won't do so until after a third miscarriage. But the tests are so expensive and the solutions if they find problems seem to be progesterone pessaries, low dose aspirin or continued metformin. I can't help wonder what the harm in just asking the GP for these without any tests could be? Or just buying the aspirin myself over the counter?
The next stage tests are for NK cells which are treated with steroids which I appreciate can't be taken lightly or without a real need. But what's the risk of taking the others if they might help and would do no harm? Any experiences before I see my GP next
week please?

[Quills]

Hi inamaymaybewrong. I have had 5 pregnancies, only two of which were successful - and they were the two I took low dose aspirin with, with the knowledge and support of my midwife and consultant. It was advised I try taking it by the early pregnancy clinic, as they couldn't do the tests (as you know) unless I had 3 successive miscarriages.

I had 2 MCs and then conceived DD1. I took aspirin until 12 weeks with her and she was delivered healthy at 39 weeks. I then had a 3rd MC after 2 years TTC a sibling for her, and on the advice of my GP I didn't take aspirin during that pregnancy. It took a further 18 months to conceive again, and this time I took the aspirin against my GP's advice, but told both my midwife and consultant who were supportive and advised I take it until 36 weeks gestation. DD2 was delivered at 39 weeks, but I did have a post-partum haemorrhage following her birth, which can be a risk with taking aspirin and is why I stopped it at 36 weeks to help minimise the risk.

I hope you get the answers and support you need, and above all I wish you a happy and healthy pregnancy in the near future.

[onefootinthebed]

Hi I am on my 5th pregnancy now and only have one child, I am 17 weeks today and this is the furthest I have got since ds. I have been taking low dose asprin since prob around 4 weeks. I believe in this pregnancy and am now beginning to relax about it.

I am so sorry for your loses, depending on your age they may start to test you know. The nhs only really offer blood tests.

I didn't know about the risks of haemorrhage when giving birth I will need to ask about this in my next appointment.

Good luck op

[nearlyreadytopop]

I'm so sorry for your loss.
1st preg - I took metformin until positive test and had ds1
2nd, 3rd, 4th preg- no metformin and I lost them all (7,9, 17 weeks).
5th preg -on metformin for 12 weeks prior to conception and then continued until 12 weeks gestation and I have my lovely ds2.
I have PCOS and after my late mc I had all the NHS tests, results came back clear. I really believe that metformin worked for me.