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Menopause

No withdrawal bleed on HRT - thoughts?

2 replies

OneMoreForExtra · 10/12/2015 13:55

Interested if anyone's had this. I've been on the lowest dose of femoston (sequential oestrogen / progesterone hrt) for 7 months, for bad peri symptoms. Worked like a dream, all hot flushes, night sweats and (some of) brain fog gone. For the first 5 months my cycle was ticketyboo. For the last 2, I haven't had a withdrawal bleed. I know that HRT only tops up your natural hormone cycle rather than taking it over, so have been assuming things are winding down on occasional months, but all the literature says this kind of HRT will cause a bleed even after menopause. Anyone been here?

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PollyPerky · 10/12/2015 15:31

sounds good that you are having some improvement!
I'd not worry. Not all women have a bleed even on sequential.

This is from a BMJ paper.

jfprhc.bmj.com/content/28/4/182.full.pdf

"On sequential HRT 85% women get a regular withdrawal
bleed and up to 15% have no bleeding.16 This is acceptable
provided the other benefits of HRT, e.g. symptom control,
are realised. Problems may occur with either the timing of
the withdrawal bleed, the length or heaviness of the bleed, or
with breakthrough bleeding. Depending on the age group,
pregnancy should be excluded, compliance checked and
pelvic examination performed unless done recently.
Antibiotics, particularly the broad-spectrum ones, may
interfere with hormone absorption. Synchronisation of the
endogenous ovarian cycle and the exogenous hormone cycle
in perimenopausal women can be difficult."

What's probably going on is that as you are on a very low dose, you just aren't getting enough oestrogen (opposed by the progestogen) to make the lining build up enough for a bleed.

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OneMoreForExtra · 10/12/2015 21:49

Thank you Polly , that's reassuring! Much googling had failed to turn up that article.

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