Abnormal PGS results

[Missbrownowl]

Hi,
We recently underwent PGS on 7 embryos that were collected over 3 cycles. All 7 have come back abnormal so our clinic will not transfer. However I am still interested in transfering as PGS is not 100% accurate and I've heard embryos can self correct as they develop. Does anyone know of a clinic in london or UK that will transfer embryos deemed abnormal following PGS?

[LilyMumsnet]

We're just bumping this one for you, OP.
We hope you get some helpful responses soon.

[LillyLeaf]

As far as I know UK clinics won't transfer fully abnormal embryos but will transfer mosaic, are they all full complex abnormalities?

[Elouera]

What exactly is the abnormality? This might determine if they use them or not.

[itwasalovelydreamwhileitlasted]

I agree with @LillyLeaf - no clinics in the U.K. I'm aware of that will transfer abnormals. I guess you have a couple of options here

1 - do another cycle without PGS and transfer whatever you get since you've said you'd transfer one of the current abnormal ones anyway

2 - find a clinic abroad who will transfer and have embryos transferred there - but may be as expensive as just doing another cycle

3 - re test the embryos - they'll need to be thawed re biopsied and frozen again so the procedure might damage them. It could also be really expensive and might just get the same result - also I don't know if a clinic will accept the new result - I've read on some Facebook groups where it didn't matter what the new result was the clinic considered the first abnormal result as the most valid - cheaper to do another cycle

Things to consider - how old you are? Over 40 and doctors expect 70% to be abnormal.
What chromosomes were involved this time?

On my 2nd cycle both my blasts came back with issues - one complex abnormal and the other Mosaic. We were allowed to transfer the mosaic but it didn't implant. We are not going to do any PGS on future cycles

[Missbrownowl]

Thank you for your advice. I'm 42 which is why we were recommended PGS. We may have found a clinic that are willing to transfer. The chances are clearly unlikely but you never know. What were the reason you have decided not to do further PGS?

[Missbrownowl]

We have a larger amount of complex abnormal and then one with -8 and one with - 22. I believe -22 is compatible with life but not on a good way so I'm not sure if that may change things.

[Missbrownowl]

As far as we know they are fully complex abnormal and abnormal. I am trying to check with the lab about the 30% they do not report on.

[Parkandride]

Why did you do PGS if you want to transfer abnormals? Have you done regular rounds?

Have you done everything you can to improve egg and sperm quality? If not I'd take 3 months to do the advanced plan in It Starts With the Egg and go again. Imagine it'll be much quicker than transfer embryos to other clinics, my understanding was that UK clinic will not transfer abnormals.

Good luck

[itwasalovelydreamwhileitlasted]

@Missbrownowl
We decided not to do any more PGS as what was the point really if were were prepared to transfer mosaic and abnormals anyway?
I don't make many blastocysts - 2 or 3 on each cycle so we don't have a lot to choose from when it comes to transfer anyway. It's not cheap and also just been downgraded by the HFEAA

Which clinic have you found who will transfer? X

[itwasalovelydreamwhileitlasted]

You may find this useful which ranks abnormal embryos in terms of best to transfer