ivf for hyperfertility?(8 Posts)
Hi all, just wondering if anyone has any experience of or has had any advice on ivf for hyperfertility.
Not sure if people know what hyperfertility is so my v. non sciency explanation is that it is when a woman's womb is not selective about the fertilized eggs it allows to implant. It accepts non viable embryos and allows them to implant when it should reject them before the period is even missed. So the woman gets pregnant very easily but may miscarry a lot as her body only rejects the non viable embryos further down the line. Hope that makes sense.
We have a DD who we are hugely grateful for. Since trying for a second child we have had 6 miscarriages (just had an ERPC yesterday). our miscarriages have all been between 6-8 weeks. Out of 7 pregnancies I have got pregnant the first month of trying 5 times and the second month of trying twice.
I'm wondering, as my body is not weeding out the non-viable fertilised eggs at implantation should we be considering ivf with the the option where they check chromosomes before putting them back in?
One of the consultants at St Mary's (Recurrent Miscarriage Clinic) suggested that because i can get pregnant naturally the odds for ivf working are probably lower than if we just keep trying. Can this be right. Anyone know what the odds are...or the expense with the chromosome testing?
Any information gratefully received.
The testing I was talking about is preimplantation genetic diagnosis (PGD).
Oops sorry- it's array cgh (comparative genomic hybridisation) or microarray cgh (slightly newer version I think, developed by Oxford uni). B
Hi - I am so sorry about your repeated miscarriages, it must be so difficult. Generally the odds for ivf working are better than conceiving naturally on a month by month basis but as your problem seems not to be getting pregnant but rather staying pregnant it may be better for you to just continue naturally and hope eventually a viable embryo will implant.
I have just been through IVF the first time (it worked!) and I asked my clinic about cgh since from what I had read it seemed to improve the odds so much. They told me they didn't offer it because you need a number of fertilised embryos to make it to blastocyst stage in order to select the best one through the testing and the vast majority of women, particularly who were in their late 30s like me, would at most get two good blastocysts so no choice really. But you may be in a different situation given your particular history. I would say definitely worth following up. Good luck!
Thank you so much for your response - and congratulations!! That's fantastic. I wish you a very happy and healthy pregnancy!
I think you may be right in terms of likelihood of success. It's just very hard having to wait for 6-8 weeks (or 9 last time, although we knew things probably weren't going well from around 7 weeks) to miscarry. It is so upsetting and, on a practical level, just takes so long!
I think the information you were given on how many viable embryos you are likely to produce in your late 30s makes me wonder if I will ever get there (but it is useful information, and not a surprise, thank you). We have an appointment with St Marys in 5 weeks time so I will ask them in a bit more detail about all these things.
Thanks again for your response.
Have you actually had your miscarried embryos tested to see if they are chromosomally abnormal?
Hi B- glad my post gave you some ideas. Another thing that occurs to me in favour of ivf for you is that once they get fertilised embryos, they wait to see which ones make it to day 2,3 or 5. This might help you to select the best ones even if you don't have enough for cgh.
I really feel for you having all those miscarriages, it must be agonising.
HDEE also raises a good point, if you miscarry again (god forbid), can they test the embryo/fetus to try to pinpoint the problem? I remember reading on the 40 plus mothers thread on the conception page that they do that in Australia at least.
Just searched for this topic due to re-occurrent miscarriages. I think since i am 40 my body is now producing duds and not weeding them out. I have a two year old.
Did you get any answers from the hospital about viability of IVF ?
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