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SSRI's - anyone done well on one after adverse reaction to another?

(15 Posts)
Ceetee23 Thu 27-Apr-17 14:33:02

Hi need some advice on SSRI's. I've had adverse reactions to a couple of SSRI's. Sertraline a few years ago when I tried 50mg a day for 2 weeks. I was plunged into a deep depesssion and agitated anxiety for 2 weeks before I got taken off them. I felt suicidal. Tried fluoxetine once and it worked in 2 weeks. The second time I got vomiting, jitteriness, agitated anxiety and deep depression/suicidal for 8 weeks before coming off.

My question is has anyone had bad reactions to one then reacted well to another?

Tried citalopram once and only lasted 3 days due to agitated anxiety and insomnia. Sometimes I wonder whether it would have gotten better.

Help! PND for 10 months and can't go on like this. Want my life back.

NolongerAnxiousCarer Fri 28-Apr-17 20:36:54

Bumping for you. SSRIs are not the only type of antidepressants though, would your GP consider other types?

APMom Fri 28-Apr-17 21:36:03

My dd was on Prozac but didn't like it, she couldn't sleep. Then went on paroxetine which kept her on a fairly even keel but didn't get rid of her OCD thoughts. A different psychiatrist recommended sertraline which she started in January and has gone so far back its awful. She's spending hours in the shower, won't leave her room etc. She stopped that (a bit too quickly for my liking) a few weeks ago and is now back on paroxetine. Hopefully we can increase the dosage enough to get rid of the OCD.

Ceetee23 Sat 29-Apr-17 15:53:47

I've tried imipramine which is a tricyclic one but got bad physical side effects that didn't go away, swear poured off my face and back and legs! Even in cold weather!

I haven't tried an SNRI though?

Thanks for bumping.

I hope your daughter improves on the higher dose, it's so hard to find the right drug. X

LaFlaneuse Sat 29-Apr-17 16:11:17


I couldn't tolerate SSRIs - anxiety, jitteriness, metallic taste, felt like I was 'on drugs' horrible insomnia etc.

The older tricyclics were too sedating for me (eg amitriptyline etc) and I couldn't tolerate those either.

My GP recommended lofepramine as a halfway house between the SSRIs and the older tricyclics.

Lofepramine worked for me, gave me a subtle get up and go, reduced anxiety and improved sleep as well as lifting pretty severe depression.

The only side effect was constipation - lactulose and or psyllium husk plus plenty of water solved that.

Ceetee23 Sun 30-Apr-17 08:17:44

Thankyou! I'll ask about that one!

Imjustsaying Sun 30-Apr-17 11:45:44

I started on Fluoxitine which didnt seem to be helping after extended use, sertraline made me very irrational and suicidal and lasted a month on them. Was put on citalopram which also made me quite agitated and anxious at first but after a few weeks they stated working really well for me. I was given propranolol along side the citalopram, they are anti anxiety meds. Maybe ask your dr about them?

Ceetee23 Mon 01-May-17 13:38:39

Thanks for that. I was wondering whether to give citalopram another go. How long did it take for the agitation etc to go away and you got the good stuff?! Also did you use the propanol just at the beginning till the side effects passed? X

Imjustsaying Mon 01-May-17 21:58:05

It probably took close to a month for my agitation to calm however I had an extremly stressful month that month too. I took Propranolol for the whole time I took citalopram, I felt they worked well together as I was a very anxious person. I came off the both 8 months after I'd started due to finding out I was pregnant. Now 9 months pregnant and Ive not had a relapse despite a stressful pregnancy. I know it can be person to person but my experience was fab! Worth a try flowers

FaithAgain Tue 02-May-17 09:14:48

I wasn't too bad on citalopram but setraline and paroxitine gave me horrific nightmares (like violent, gory details). My GP started me on lofepramine. Only side effect has been dizziness on standing (which I can manage through taking my time and staying well hydrated). I also don't have the numbness I felt on SSRIs. Definitely worth discussing options with your GP.

StripeyZazie Wed 03-May-17 01:26:21

Citalopram did settle down for me after a couple of weeks, then started to feel a lot better after about a month.

When my pharmacist switched from one manufacturer to another I did get a bit of a reoccurrence of the initial side effects-insomnia, slight vertigo & sensitivity to bright lights. But I phoned my doctor about it, he phoned the pharmacy and they found some of the previous stock for me.

Ceetee23 Wed 03-May-17 13:11:33

Thankyou. Starting citalopram 5mg tonight and go from there. Wish me luck! Thanks for your support x

Mombie2016 Wed 03-May-17 13:14:18

I had bad reactions to several SSRIs with Fluoxetine landing me in hospital. I've been in Amytriptylene- a TCA - for 6 years now. I'd never touch an SSRI again, a year of absolute Hell for me.

Imjustsaying Wed 03-May-17 21:54:21

Good luck op, let us know how you get on

Ceetee23 Wed 31-May-17 20:56:16

Well a month or so later I'm actually starting on 5mg citalopram! Will let you know how I get on. Fingers crossed

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