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How long for quetiapine to work? Am I just being stupidly impatient?(3 Posts)
Brief potted meds history. Starting taking 100mg of Trazadone 5 weeks ago, was then upped to 150mg 3 weeks ago. But mood has stayed very depressed, and anxiety just as bad. Sleep improved a little bit though (but always awake by 4.30am, feeling very anxious).
Told my CPN last week that I just didn't feel the Trazadone was helping me at all, so I was prescribed Quetiapine a week ago to help. Started on 25mg at bedtime and 25mg at breakfast. Then after 3 days upped to 50mg at bedtime and 25mg at breakfast. But still waking at 4.30am feeling very anxious, though cat-napping now for a couple of more hours. Felt so horribly depressed over the weekend, but sleepy at the same time.
Yesterday I saw the Crisis Team doctor for a meds review, and I told him I still didn't feel any improvements, and that I felt the Trazadone/Quetiapine wasn't doing anything other than perhaps aiding my sleep.
But he just suggested upping my Trazadone to 200mg at bedtime + 75mg of Quetiapine, then 25mg of Quetiapine at breakfast. I felt really upset, and feel that my meds are just being upped and upped, but they're just not going to work on me.
Last night (but before I took the new meds regime) I suddenly felt much calmer, and enjoyed a lovely evening with DH just being 'normal'. This also happened last Thursday afternoon, no idea why?
This morning I woke at 4am, but fell back to sleep until 6.45am, without cat napping. But within minutes of waking the anxiety pounced, and has stayed all day. Have been crying on/off too. I have zero motivation, everything seems pointless, though have forced myself to do some laundry and a quick tidy up.
But WHEN can I expect to feel consistently more well? After 5 weeks on Trazadone + one week on Quetiapine I was expecting to have more improvement than this. By now, perhaps a couple of good days followed by a bad day etc. I don't think I'm asking the impossible am I? Everything I read about ADs now, says you can expect signs of improvement after 2-3 weeks! But clearly not for me!!!
Or is it just too early days yet to expect anything more really? Are those few hours last night, and last Thursday all I can reasonably expect so far? My depression and anxiety has been with me, untreated, to a greater/lesser extent for over 2 years. So am I expecting too much to feel more well than this after just 5 weeks?
It's just that the bad days are so unbearably bad. It's more like despair than depression to be honest. Most days I don't know how I can possibly make it through the next 15 minutes, let alone until the end of the day. But somehow I do.
Thank you for listening to my moanings xxxx
The dose of quetiapine you are on is still low are they increasing it? 300mg - 600mg a day is the BNFs usual dose.
I think in practical terms, the Trazadone should be working by now but obviously wasn't working for you at the previous dose / alone. So you need to give it a bit more time for the higher dose + quetiapine to start working. Not quite starting over, but another step to work from.
I'd want to give it maybe 2 weeks after your dose of both is at a stable level to fully assess the effects. That doesn't mean you wouldn't see improvements in that time, just that it wouldn't be fair to judge it fully until then.
I know that might seem like a long time when every minute is a struggle but hopefully it will be getting gradually easier and you'll have more calm periods.
You will get through this, you already are doing.
Thank you so much for replying Mandatory.
Is 100mg still a low dose of Quetiapine, if it's just being prescribed as an adjunct to an AD? I am being treated for just standard depression/anxiety and don't have bi-polar.
I am praying desperately for more calm periods, over the next few days, as I really don't know how I am dragging myself through each day. I really don't. I get to the end of each day and I'm stunned that I'm still here and functioning.
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