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Oxford vaccine - T-cell immune response and risk for pre-existing autoimmune disease

(8 Posts)
trulydelicious Mon 03-Aug-20 09:36:52

I am really not very knowledgeable regarding vaccines in general (so, apologies if the question seems a bit confused or daft blush). I am also not against vaccination in principle.

Do the vaccines that have been around for a long time (e.g. tetanus, polio) aim to generate a T-cell immune response as well as to generate antibodies?

Or is this technique / outcome something unique and novel to the Oxford vaccine?

I'm slightly concerned about this T-cell response after vaccination and whether it could be problematic for people with pre-existing autoimmune conditions (exacerbating the condition or causing additional autoimmune diseases) .

I have seen several references to this, one of the articles is the following:

www.sciencefocus.com/news/coronavirus-oxford-vaccine-shows-strong-antibody-and-t-cell-immune-response/

OP’s posts: |
MRex Mon 03-Aug-20 09:43:24

I'm not an expert, but I think that normal for any vaccine? Pertussis, Diptheria, MMR, etc etc.

MRex Mon 03-Aug-20 09:44:54

The T-cell response I mean, not the impact on those with an auto-immune disease. There have been no specific issues for Hashimoto's etc that I'm aware of from covid, so there's no reason the vaccine would affect this.

NewNewt Mon 03-Aug-20 09:46:24

Its part of the body's normL response to a vaccine, or indeed, any antigenic challenge including getting a virus. I'm not sure how having an autoimmune condition would affect that though, I'd guess it depends on the specific condition. I think your immunologist would be best placed to answer that.

SexTrainGlue Mon 03-Aug-20 09:47:49

Interesting article about the development of both the Oxford and the Imperial potential vaccines. Including whether they'll be safe for those with immune systems highly weakened by blood cancers (current answer: probably)

bloodcancer.org.uk/news/coronavirus-vaccine-will-it-help-people-blood-cancer/

bloodcancer.org.uk/news/coronavirus-vaccine-will-it-help-people-blood-cancer/

trulydelicious Mon 03-Aug-20 09:57:08

@MRex Yes, it's just that I have seen the emphasis placed on the T-cell response on several articles and I don't recall one explaining whether this is specific to this vaccine or common to others as well

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MRex Mon 03-Aug-20 11:47:17

@trulydelicious - and as I said, there is T-cell immune response from other vaccines, I don't know whether all of them or not because I'm not an expert.

trulydelicious Mon 03-Aug-20 18:21:35

*@NewNewt *It is understood that T-cells are 'overactive' in some autoimmune conditions, that's why I wondered if it may be detrimental for those already with autoimmune conditions to send T-cells into further overdrive with the vaccine.

OP’s posts: |

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