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IVF - defrosting and emplanting embryos

(16 Posts)
successful Tue 14-Jun-05 21:11:59

I have frozen enbryos in the freezer at our local clinic. We are just about to embarking on the procedure of having them defrosted and emplanted.

I have a friends whose embryos all died on defrosting and another who went on to have a live birth.

Has anyone else done this? did it work? your stories?

What happens?????

Pruni Tue 14-Jun-05 21:26:26

Message withdrawn

successful Tue 14-Jun-05 21:38:09

Wow Pruni - I will be thinking of you. Do you have any other children through IVF/ICSI?

Our prelim meeting is Friday 24th June and I feel quite sick at the thought.

zebraZ Tue 14-Jun-05 21:39:52

I know Lance Armstrong's twin DDs were the result of "defrosted" embryos.

Pruni Tue 14-Jun-05 21:46:56

Message withdrawn

successful Tue 14-Jun-05 21:49:49

Yes we are very, very lucky and everytime DS (18mths) has a temper tantrum I remind myself that .

I also never knew that Lance Armstrongs twins were IVF and defrosted at that. There is hope.

Ladymuck Tue 14-Jun-05 21:57:34

Hi I was told at my clinic that the defrosting often depended on the degree of fragmentation in the cells (which they graded on a scale of 1-5). Obviously they will select the "best" embryos for the fresh transfer, and then freeze the best of the rest (or potentially if some are good, they will freeze them all anyway).

When it coms to defrosting, the embryos will have been stored in straws (usually up to 3 embryos per straw I think). So the entire straw is defrosted to see if the embryos survive (and preferably divided). Again they can put back 2. So in terms of numbers that they defrost at a time, they should only defrost sufficient straws in order to obtain 2 surviving embryos.

My embryos were quite fragmented (grades 2 and 3) and didn't survive the defrosting. However I know plenty of "frosties", and the rates seem to be improving annually - used to be about 10% success rate, but seems to be higher now.

successful Tue 14-Jun-05 22:00:17

Hi Ladymuck - can I ask, how long ago was this that they didn't survive and what were/are you next steps? Apologies if this is too intrusive and don't answer if you don't want to.

jenkel Tue 14-Jun-05 22:04:39

Gosh, this takes me back.

Unfortunatly we lost all of ours (4). I was totally unprepared for that, I was on a medicated cycle and felt really confident the whole time, so was totally distraught to learn that all 4 had perished.

We then changed clinic and then thankfully had a succesful fresh cycle, the results of which is hopefully asleep next door (dd almost 3).

Then somehow, fell pregnant naturally and now have another dd (1).

However, one of my friends has a ds frostie who is the same age as my oldest daughter so it can work.

Good luck

Ladymuck Tue 14-Jun-05 22:25:11

This was after our first IVF attempt in June 1999. We were very keen to give the chance of life to all of our embryos, so we froze the grade 2 and 3 embryos against the clinic's advice (it would usually only freeze grade 1 embryos). We went on to have a second cycle of IVF , where we had a Day 3 transfer (to indicate which embryos were better at multiplying),which was also unsuccessful, with no surviving embryos to freeze. I had an ovarian diathermy in April 2000 and our third IVF in June 2000 resulted in ds1 - again no survivors and the embryos transferred were of "poor quality". We had a fourth IVF attempt in Augst 2002 which resulted in ds2, and some additional embryos which were graded 4 and 5, so we decided not to freeze. IVF attempts 3 and 4 were also Day 3 transfers.

Ladymuck Tue 14-Jun-05 22:28:15

And for avoidance of doubt ds1 and ds2 are safe and well, asleep upstairs. Ds1 went for his school uniform fitting today - he looked so grown up - and to think I can remember when he was only 4 cells!

successful Tue 14-Jun-05 22:30:11

Thank you for sharing that with me, I really appreciate it. Two gorgeous boys, I'm sure they are a joy

Portree Wed 15-Jun-05 15:07:14

My ds is 18 months too. He was the result of our first fresh IVF/ICSI. That cycle we had no embryos suitable for freezing.

We had a subsequent fresh cycle in Jan this year which yielded 8 embryos out of 16 eggs (we have severe male factor). 7 x grade 1 and 1 x grade 2. Transferred the best 2, BFN. Then had frozen-thaw cycle, unmedicated, in May. Both embies survived the thaw and continued to divide after thawing, BFN again. So we have 4 left and we are having transfer tomorrow (yikes!) - I'm very anxious about the whole thing to be honest. I'm hoping that we get 2 out of the 4. At my clinic their average thaw rate is 70%. Mine were frozen in 2s and 1s, so if they thaw a straw of 2 and only 1 survives they then thaw a straw of 1, so none are wasted.

As to success rates, my clinic's rate is about 28% live birth rate per cycle (cf 53% for a fresh cycle). I'm having another unmedicated cycle which is a lot easier than taking loads of drugs, it makes the process much less loaded. Plus you don't need a break between cycles for the drugs to get out of your system. If this FET doesn't work we'll do a fresh cycle in Aug/Sept and push for the transfer of 3 embryos as I'll be 40 then.

Good luck.

expatinscotland Wed 15-Jun-05 15:09:42

All three of Lance Armstrong's children are the result of IVF. His treatment for metastatic testicular cancer rendered him infertile. Sperm samples were collected from him before he underwent treatment.

successful Wed 15-Jun-05 19:19:43

Portree good luck for tomorrow I hope they are suitable for implanting and then it will be good luck for two weeks tomorrow when the test takes place.

My friend whose 'frosties' died, I saw her today and she has undergone a complete new cycle and tests on Monday.

Lance Armstrong & his wife have been successful. I wonder how many attempts it took them.

successful Sat 25-Jun-05 18:24:53

Hi all I have had my appointment and we should start the defrosting etc in August.

Friend whose frosties died, did the full cycle and it failed

Portree - how are you doing?

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