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Immune/natural killer cell treatment when TTC or pregnant (aka the 14th pred thread)

(994 Posts)
sunnyday01 Sat 29-Nov-14 13:57:25

Continuing from 13th thread

sunnyday01 Sat 29-Nov-14 14:00:44

13th thread

sunnyday01 Sat 29-Nov-14 14:01:04

Hope everyone finds this ok!

Mel3062 Sat 29-Nov-14 14:04:43

Thanks sunny ;)

dildoos Sat 29-Nov-14 14:11:14

Thank you sunny! X

Tryingno1 Sat 29-Nov-14 16:11:15

Hi guys! Had a lovely time away. All relaxed and refreshed
Hope-how was ur hcg? I have my fingers and toes crossed
Determined I'm sorry to hear that-could it be that it's coz u tested late at night? Did u retest this am? Keep taking the pred I would say...hope ur ok....
Rosa sorry ur feeling down. I think we have been ttc similar times now. Hard to worry its never going to happen again...but im hoping its just a matter of time....hope ur feeling better.
Dildoos-yes can def drink on the pred! So enjoy urself x
Also can we all put a little summary of ourselves as I'm rubbish and forget! Seeing as its a new thread and some new joiners? I'll go now...

Tryingno1 Sat 29-Nov-14 16:15:20

Oh and thanks sunny!

Me - 30. DH - 34
Ttc since April 2013.
3 miscarriages. June 2013 6 weeks. Sept 2013 9 weeks after seeing heartbeat sad needed ercp. May 2014 at 6 weeks needed ercp.

Have slightly raised nk activity but normal levels. For pred/intralipds/progesterone combo.

Currently feeling ok/maybe in denial as brain tired from worrying EVERYDAY. On cycle 5 of TTC this time and hoping it happens soon.

dildoos Sat 29-Nov-14 16:44:45

Thanks trying! You have made for a happy lady :-)

Ok here goes

I am 34 dp 32
DD6 from previous relationship took 3 years to conceive had a constant period bleed throughout pregnancy. Ended small for dates and heart defect.

Been TTC for 42 months started June 2011.
7 mc later and just even diagnosed with high functioning NK cells which may have been my first pregnancy issue.

DP is the only daddy in my little ladies life and it's an amazing bond they have so I realise how lucky and blessed I am already.

Just hoping for a longed sibling for DD and a biological child for myself and dp to share also.

Long story really! Sorry!

Glad to be a part of this thread x

Determined123 Sat 29-Nov-14 17:11:03

Thanks for sorting Sunny smile

Following on from thread 13, Dildoos yes same type of test (although cheapy one and did a repeat this morning, same result sad) and thanks Rosa/Trying still not 100% sure what to do so will prob stay on the pred/prog although started to spot ever so slightly so its pretty clear what is happening - oh joy!

Dildoos - yes you can drink on pred (thankfully!). Be careful if you are on metformin though (not sure if you are? I am for PCOS) as it can make you quite poorly if you over indulge.

Will put a summary on the next post x

dildoos Sat 29-Nov-14 17:13:48

Determined can you get in for a scan soon to see what's going on or bloods? X

Tryingno1 Sat 29-Nov-14 17:17:27

Determined so sorry sad....Yes can u go for bloods or early scan? I would keep going with pred and progesterone till u know for sure? Some
People say the progesterone can delay the bleeding side of things though...but I'm sure ur epau will do hcg/scan and let u know either way. sad

Determined123 Sat 29-Nov-14 17:36:13

Here goes...(slightly long one)

Me 32, DH 36
TTC since July 2013. 2 miscarriages (Jan 14, 7 weeks, April 14, 6 weeks) and then of course whatever is happening now (at only 5 weeks!).

Have PCOS, borderline NK cell levels (but I think the activity is high!?) MTHFR and very high thyroid anti-bodies. After my second miscarriage I was exhausted for weeks which I didn't think was just the upset of it all so I knew something which wasn't quite right and found Dr S after then.

Treatment wise I am on metformin for the pcos, (and aspirin and vits etc)pred after Ov and prog and this month was my second doing super ovulation. Due to the PCOS I was ovulating really late (day 20+ on a 30-32 day cycle so luteal phase too short). Oh and also have to have intralipids from BFP.

As I type I am feeling ok ish (considering)...i am sure i will be up and down over the next couple of days but i am trying to stay positive that i got pregnant so it will happen again and it will be successful!!! smile

Sending positive vibes smile


Determined123 Sat 29-Nov-14 17:44:50

thanks Dildoos/Trying will deffo try and do that for peace of mind!! x

sunnyday01 Sat 29-Nov-14 19:14:43

Here goes-

I'm 32, DH is 35 - we've been trying since January 2013. Got pregnant first month but had lots of bleeding, had 2 scans at local pregnancy unit even saw heartbeat but had a mc at 8 weeks.

Got pg again in October 2013 and only knew for about 3 days before the bleeding started again mc at 5/6 weeks.

Went to see local hospital fetility specialist - waste of time and basically told me to go away and loose weight. Did research and found DR S.

I have high nk cells (not sure about activity) on pred at ov, then intralipids and progesterone from positive preg test.

Just going in to round 4 of SO.

Feeling generally ok, frustrated that I haven't been able to get pregnant for over a year now but hope that positive test is not far away!

Hopender Sat 29-Nov-14 21:53:06

Thanks Sunny!
Hope you are ok Determined. Sending you a big hug. Life is so cruel sometimes but there will be happier times ahead.
My story is as follows...
I'm 38 and DH is 36. We have a three year old DS. We had three miscarriages before him and have had four since (one very late, another little boy when I was six months pregnant last year. The others ranged from six weeks to 10 weeks).
I am now five weeks pregnant again and on treatment for the first time. Had bloods taken today and they have gone up from 2017 to 3966 in 48 hours. They say that is good enough. I hope so! I am having a scan at epu on Monday to check if sac is developing or something along those lines I think.
Hope everyone is managing to keep spirits up. When we lost our little boy last year I thought I'd never feel happy again but time does help. I also know that miracles can happen because we have our DS, who was born a whopping 9lb 3oz after no treatment.
I am on prednisolone, cyclogest and intralipids at six weeks. Dr S says I have high gliafin

Hopender Sat 29-Nov-14 21:56:28

Oops, sent to soon. Meant to say Dr S says I have high gliadin antibodies which are causing me to have an auto-immune response to any pregnancy. It can be variable though.
Sending you all lots of positive vibes for lots of BFPs this month. Thanks so much for the support this week too. It has meant a lot, xxxx

Tryingno1 Sat 29-Nov-14 22:06:09

Hope been waiting for
Update. So glad to hear about ur hcg. And hope scan goes well too smile. I know it's still early days but its starting off well smile

Hopender Sat 29-Nov-14 22:23:23

Thanks so much Trying. You are such a sweetie. Hospital didn't ring until 5.30pm and then I had dinner plans with the girls (just as well it was good news). I came up with various rubbish reasons for why I wasn't drinking! Then got I on mumsnet as soon as I was home. DH is wondering what I'm up to on my phone the whole time! Is it a week until you ovulate again? I think we were all in sync last month! So hoping for BFPs for you all this month! Xxx

dildoos Sun 30-Nov-14 08:01:22

Fab news hope! Hope the scan aids outing your mind at ease.
How are you today determined?

Tryingno1 Sun 30-Nov-14 09:33:23

Hi hope. Yep on day ten today...doing alt day DTD and not going to panic if the odd day missed?! (I tell myself). Don't think it will get me my bfp though...but there's always next year too? I starting to think this bfp is a long way away...but just got to be patient
Dildoos hope u enjoyed ur night out!

Determined123 Sun 30-Nov-14 09:38:19

Ahhh that's fantastic news hope! I am so pleased you have a positive start and good luck for the scan smile
Yes I am ok this morning (without tmi it's all full on now). Will phone Louise tomorrow and ask about next steps as I did have my scan booked next week anyway. Just keeping busy today...I hope you all have a nice Sunday planned xx

dildoos Sun 30-Nov-14 10:38:00

Thankyou trying I had a lovely night out smile and a few prosecco's grin

Determined sad sorry your going through it thanks

Rosa27 Sun 30-Nov-14 12:01:05

Thanks Trying .. Nice to have support here.
Determined - hang in there.. be good to yourself and try stay positive.
Hope- so happy to hear things still going well. I think I've most in common with you in terms of background though no children yet.. I will post my bio now..

Rosa27 Sun 30-Nov-14 12:02:23

Sorry this is long .. But here's my bio...
Me - 38 DH - 36
TTC since 2011/12 but didn't try properly until 2 years ago.
3 miscarriages between Aug 2013 and July this year. 11 weeks (MMC, heart beat seen at 7 weeks, D&C), 6 weeks (natural MC), 8 weeks (MMC, heat beat seen at 7).

I have a high TNF Alpha, a high natural killer cell count and very high activity as well as cytotoxicity assay. I also have high thyroid antibodies and a high TSH but that's now dropped to correct levels as taking 50mg of thyroxine.

I am on the complex treatment programme which is asprin, vits, pred, cyclogest and intralipids from BFP- but had to take Humira injections first. I had an allergy to Humira and side effects to stopped both.

Currently feeling ok considering - but have mini-breakdowns from time to time usually at night when time to think.. It frustrates me as makes me feel like I'm not coping but hopefully it's normal all considered. I have a quite a stressful job with long hours so R&R can be a challenge!

On cycle 4 this time and after tracking via every route before just DTD around time I thought was ov and not taking any drugs this time other than asprin. I don't have high hopes as conceiving taking ages sometimes so v worried about age. Will take pred, cyclogest and intralipids from BFP if get lucky. Starting to worry DH should be tested too... His BMI is 25 and he's trying to bring it down.

Anyway that's me.. Long but better to do it in one go!

Tryingno1 Sun 30-Nov-14 13:59:36

Hi rosa. I'm off the pred and asprin this month's month 5 and I'm worrying about my DH sperm
Too...I'm giving it to month 9 and then getting tests done. It's totally normal to feel like utter crap some days. I commonly break down and cry non stop and feel so shit...last 2 weeks I've been happier just hoping this feeling lasts as its unbearable sometimes when u feel pants...
Have u got fun things planned over Xmas and some time
Off? Hugs to u

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