How long does it normally take to experience side effects after taking the dose? I took my first dose on Saturday night and felt absolutely fine, but today I'm very tired. I was feeling pretty tired anyway so it could be unrelated I guess, or the clocks changing might not have helped, but I do feel worse.
I feel really nauseous today as well. Really hoping it's a coincidence and that the effects don't kick in during the few days following the dose. I've got a bad cold so hopefully that's why I feel crap, I've got to build the dose up over the next few weeks and I won't be able to cope with feeling worse than I was before!
Yes very slow... perhaps tonight someone will swing by. I got my appointment through today, earlier than I thought. 14th November, guessing this is when they will put me on it. Let’s hope someone comes along with some wisdom about it all.
I take it on a Friday night, right before I fall asleep. I've been increasing my dose from 7.5mg in July to 20mg as of last Friday.
I'd say for me I feel "yuk" the next day and definitely tired on the Sunday/Monday. It's also completely killed my appetite!
I also take folic acid every day except mtx day as directed by my nurse. It's meant to help with the side effects. I also take buccastem for nausea (I get migraines so I have this medication on hand - you can get it OTC).
I was so worried about taking this medication and it took 2 years to actually get on it due to recurring infections (!) but it is really helping me (psoriatic arthritis). x
I've taken it for over 20 years. It isn't an easy drug to take and I found day 2 or 3 was when nausea and generally feeling grungy hit. I'm currently on a very low dose and free of side effects. I was reluctant to start it but within 4 or 5 weeks the disease it was prescribed to modify had indeed been modified so I've persevered.
hi, I have been on Methotrexate for 2yrs. I started on tablets but now inject. My symptoms are much improved (psoratic arthritis). nausea is now non existent but I do feel "off " the day after taking the drug. I had an episode of neutropenia in the Summer which resolved after 2 weeks off medication. I have some hair loss but fortunately I have thick hair so not noticeable. I do sometimes get mouth ulcers.HTH
So quite a few seem to experience a lag between taking the dose and feeling off colour. I'm feeling better today, so it seems to fit. I do have folic acid to take on the days each side of the dose, it seems some take it every day except Methotrexate day. I think I'll get some anti nausea tablets for next week. I'm really hoping it helps, I'm having a bad flare at the moment and it was a big decision for me but felt I had to try. I have ankylosing spondylitis and psoriatic arthritis.
@CharlieSierra@ButterfliesandMoths, I've been methotrexate for psoriatic arthritis for about 5 years now, and worked my way up to 25mg/week which I'm now injecting on a Monday (Metho Monday and Folic Friday!) The side effects definitely last a few days, with a general feeling of fatigue, I find I can fall asleep at the drop of a hat. Today is the first day this week I am actually achieving much and there's loads to catch up on. It does really help with the symptoms of PA though, make sure you get your bloods checked regularly. The methotrexate alone wasn't enough to keep it fully under control and I now take Cimzia as well. I feel like a pin cushion sometimes .
You might find that the PA makes you tired anyway, and with the added effect of the methotrexate you will be more tired. However, once the mtx kicks in and the PA symptoms diminish, you will be used to the effects of the mtx and how it makes you feel, you might find you've got more energy and less pain than you've had for some considerable time. I also find eating cleanly around medication day helps, it seems to put a lot less pressure on the body to carry out digestion.
As a side note, did you know people who take immunosuppressant's should have more regular smear tests. I was told off recently when I attended my 3 year check and was told it should be annually.
As a side note, did you know people who take immunosuppressant's should have more regular smear tests. I was told off recently when I attended my 3 year check and was told it should be annually
I did not know this, and if it's the case for me too (post menopause) I will have to reconsider as I simply cannot tolerate smear tests. I had one under general anaesthetic a few years ago when I was having a cystoscopy and thought I had 5 years before I needed to think again about what to do. That is really worrying.
Re the tiredness, feeling exhausted to the point of being barely able to function is part and parcel of my condition, so hopefully the mtx side effect tiredness will be nothing in comparison.
Used to take methotrexate on a Friday night. By Sunday I could barely lift my head off the pillow. Would just knock me out. Would be right as rain by the evening. That was the only side effect I ever had.