It's going to depend a bit on your DC but as a general rule I would say absolutely fine. We left my DS when he was 16 while we went on a short holiday because he has always had incredibly high levels of responsibility. My DD I would leave check lists, phone her often and fret but I'd still let her stay here alone. She's forgetful but I trust her to make sensible choices.
They are ll different. It's mostly about to you trust them to make sensible decisions in a mini crisis. I occasionally so DD 'what would you do if the dog got out' or 'what would you do if a pan caught fire' so I can calibrate her potential for fuckwittery.