I agree with Givemeaclue, non-malaria-risk safari is a definate must! Look at the different reserves in the Western Cape area (Port Elizabeth to Cape Town region) as there are a number here and all non-malaria-risk reserves.
Also, the Western Cape has a number of other attractions that I'm sure you will enjoy too.
Have a look at http://wikivillage.co.za/globe-discoverers-unite-africa/ for some tips on things to do and see as well as http://www.globe-d-u.com
Let me know if I can be of any assistance in your planning of this trip.
Planning a ten day holiday for early next year, will be in second trimester of first pregnancy. Considering something involving wildlife but a bit stumped re practicalities. Want something extra special as it will be the last one in a while!