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The basic idea is that the milk is thicker so less likely to come back up, so should work pretty quickly. If you have a real puker on your hands you will need to keep them upright or as near as you can get to it for at least half an hour after a feed to give the stomach chance to empty a bit. They may also sleep better on an incline with the cot/Moses basket raised up about 3 inches at the head end.