Try looking at Paperchase's 'traditional photo album' - cloth bound albums in various formats and sizes, with acid-free pages and interleaving tissue pages. I bought one for someone but I doubt she's used it yet so I can't comment on practical quality, but it did look very nice and solid in the shop when I bought it! They also do a version with self-adhesive pages.
Have you printed the photos yet? 500 is a lot! Have you seen Snapfish's collage prints? You can include several images on one print and they come in 3 sizes: 6x4, 7x5, and 10x8. They're a great way of combining several images on one sheet and not taking as much room as individual prints.
You can buy large 12x12 albums, and also photo protectors that hold 6 (i think) 6x4 photos. If you need that many photos though, you might be better off with a normal photo album as it would get very heavy if you scrapbooked all those photos.
Hi, I'm after some advice please. I need a really good scrapbook, with lots of pages, to hold a three week Florida holiday diary with about 500 photos! Something that's going to last, so I can read back about my holiday and wish I was back there ;) Thanks in advance