Big 'C' and little 'e' antibodies

[womaninthewildsofwales]

Hi, second pregnancy where these have shown up- last time nothing came back as positive for antibodies until 28 weeks and then every time I mentioned it, the consultant brushed it aside and talked about my history of preterm birth instead. Meaning that me and dh had no idea that this could cause a problem with a further pregnancy... and here we are! 16 weeks pregnant with every alarm bell in the hospital sounding when I have a blood test my titre levels are 1:64 for C and 1:2 for e.

Can anyone shed any light on what the problems may be that we face? Or has anyone got experience of these antibodies?

[AliBingo]

I had the little e ones in 3rd pregnancy but they never increased to a significant level. Think the risk was anaemia in newborn requiring a transfusion, or in extreme case may have needed to deliver early in order to treat. But apparently almost all if the time, it's all fine and no need for treatment.

[AveEldon]

Some other threads with useful info www.mumsnet.com/Talk/childbirth/2458877-Anti-little-c-antibodies
www.mumsnet.com/Talk/childbirth/957909-Sigh-Any-mothers-with-stories-about-anti-little-c-antibodies
www.mumsnet.com/Talk/pregnancy/2489807-Anti-E-antibodies

Here is the RCOG guideline
www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg65/

Have they checked your DH's blood type?
Have you been referred to fetal medicine?

[wyattjackd]

Your titer will be repeated and if it increases by 2 fold or more it is significant.
Fetal monitoring and intrauterine transfusion (IUT) may be required.